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Summer Courses in Respiratory and Cardiovascular Systems Modeling: From Cell to Organ

REGISTER for Session 1: Respiratory Systems Modeling June 15-21, 2008

REGISTER for Session 2: Cardiovascular Systems Modeling August 24-30, 2008

Facilities: The courses will be held in the Advanced Computing Lab in the new W.H. Foege Building at the University of Washington, Seattle, Washington. Participants will have internet access for their own laptops provided by the University of Washington.

Faculty from the Departments of Bioengineering, Medicine, Physiology, and Radiology at the University of Washington include Joseph Anderson, James Bassingthwaighte, Daniel Einstein, Fen Gao, Robb Glenny, Jack Hildebrandt, Michael Hlastala, Senthil Kabilan, Melissa Krueger, Gary Raymond, Thomas Robertson, James Caldwell, Ken Krohn, Hong Qian, Michael Regnier, Herbert Sauro, and Chun Yuan.

Goals: Under the direction of an experienced faculty, course participants will learn basic physiological systems-level modeling, using the cardiovascular and respiratory systems as their guide. Upon completion of the course, participants will be able to
  • Examine data for consistency and interpretability;
  • Devise potential explanations for the data;
  • Translate ideas into testable hypotheses;
  • Express the hypothesis in quantitative terms;
  • Constrain model parameters by anatomy;
  • Evaluate models to assure correct computation;
  • Optimize model parameters to fit solutions to data;
  • Determine the relative sensitivities of a model to parameters;
  • Analyze the accuracy of the estimated parameters;
  • Use models to test ideas and design experiments;
  • Compare and select the best models.
    		•
    General Topics covered in both sessions:
    Examining experimental data for mechanistic interpretation in terms of:
    • Solute and water flows across membranes;
    • Convective and diffusional transport;
    • Reaction kinetics and metabolic networks;
    • Cellular electro-physiology and ion pumps;
    • Capillary-tissue eschange processes;
    • Mechanical properties of cells and tissues;
    • O2 and CO2 exchange with blood.
    		 Computational approaches:
    • Defining models of physiological systems;
    • Setting up differential equations for numerical solutions;
    • Optimization, and parameter sensitivities and estimation;
    • Testing models for accuracy and for validation against data.
    Special Topics:
    Session 1: Respiratory Emphasis (June 15-21, 2008)
    • Lung and airway mechanics;
    • Alveolar exchange;
    • Pulmonary ventilation and perfusion;
    • Pulmonary function testing;
    • Surfactant effects;
    • Bronchial blood flow and exchange of lipid soluble gases;
    • Image analysis for pulmonary circulatory transport.
    		 Session 2: Cardiovascular Emphasis (August 24-30, 2008)
    • Pressure/flow relationships in vessels;
    • Vascular mechanics and transport;
    • Circulatory volumes and transit times;
    • Electro-physiology and excitation-contraction coupling;
    • Analysing MR, PET, and CT images;
    • Cardiac mechanics and metabolism.

    Target audience Academics and others directing and working in cardiopulmonary-related research, clinicians, research scientists, and post docs wanted guided experience in physiological modeling. No specific programming experience is required.
    Participants can expect to be able to integrate modeling analysis to their scientific research and clinical applications development. We encourage participants to bring their own experimental data sets to analyze under the guidance of course instructors.

    Course enrollment is limited to twenty-five people, and we encourage early registration. We regret that course participation is restricted to U.S. citizens and Green Card holders.

    To register, please fill out the On Line Registration Form

    Registration for Session 1 ends on Friday, May 30, 2008.
    Registration for Session 2 ends on Friday, August 8, 2008.

    Fees and Scholarships: The fee for the course is $400. Participants are responsible for the cost of transportation, accommodation, and meals. Scholarship money is available for course fee waivers and travel stipends preferably for new investigators. Applicants interested the scholarships must, in addition to filling out the registration form, send a one- page letter that demonstrates need and a defined interest in the field of modeling, along with two letters of recommendation to Mr. Gary Raymond. Application deadline for scholarship aid for Session 1 is Monday, May 19, 2008. Scholarship applicants will be notified of their application status on or before May 26, 2008. Application deadline for scholarship aid for Session 2 is Monday, July 28, 2008. Scholarship applicants will be notified of their application status on or before August 4, 2008. Please address all scholarship queries to Mr. Raymond.

    Upon acceptance, please mail a $400 check or money order, made out to The University of Washington to:
    Mr. Gary Raymond
    Department of Bioengieering
    Box 355061
    University of Washington
    Seattle WA 98195-5061

    [This page was last modified 04Apr08, 10:12 am.]

    Model development and archiving support at physiome.org provided by the following grants: NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.