Single Channel Model
Description
Based on the revolutionry experimental observation on single membrane ion channel conductance carried out by Neher and Sakmann, a stochastic kinetic model based on Markov jump process was developed. The essential idea is that a single channel protein has several distinct conformations and the transition between the conformations can be characterized by a radioactive-decay-like process. Of course, treating a protein with a set of discrete state is only an approximation.
Interesting Links:
http://www.biophysj.org/cgi/content/abstract/76/2/782
Last modified 19May05, 12:36 pm.
Model development and archiving support at physiome.org provided by the following grants: NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
