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Hudgkin-Huxley

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Winslow-Rice-Jafri-Greenstein Model

Description | Equations | Implementation | Examples | Discussion

Discussion

The model has tried to analyze the influence of voltage-dependent calcium (Ca²⁺)-independent transient current (I_to1) on the action potential duration (APD) in normal vs failing canine and human cardiac myocytes. It also takes the influence of the Kv4.3 encoded current (I_Kv4.3). The results show strong coupling between L-type Ca²⁺ current and I_Kv4.3, and predict a bimodal relationship between I_Kv4.3 density and APD. Also, perturbations in I_Kv4.3 density may produce either prolongation or shortening of APD depending on the baseline I_to1 current level. 

The limitation of this model is Na⁺ current does not balance (there is no mass balance).