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Winslow-Rice-Jafri-Greenstein Model

Description | Equations | Implementation | Examples | Discussion

Examples

The cardiac action potential when a stimulus of 45mV is given after 20ms for duration of 1ms.

Run the model. Under Results, display plot Area 1. 

Five simulations have been set up to reproduce the figures that appeared in the Circ. Res. paper by Greenstein et al., 2000.

Electrophysiological characteristics of the model-simulated hKv4.3 currents at 35 ^oC. (file: circres00_fig2a.par)

Voltage-dependence of peak current for the I_Kv1.4 model at room temperature. Peak current-voltage relationship normalized to the peak current at +100 mV. (file: circres00_fig3a.par)

Canine I_to1 model electrophysiological characteristics at 35 ^oC. Peak current-voltage relationship simulated from a holding potential of -80 mV and normalized to the peak current at +60 mV. (file: circres00_fig4a.par)

Note: The parameters of the Kv1.4 model were fit based on data obtained at room temperature (21 ^oC) and were then scaled  to 35 ^o C using a Q₁₀ value of 3.6 based on measurements of inactivation kinetics made on native I_to1 (see the online data supplement to Greenstein et al. for details). The calculation of the scaling factor is

Q₁₀^(T-294)/10 = 6 when the temperature T=308 K (or 35 ^oC).

Note that the scaling factor needs to be applied to only four parameters, alpha_a0, beta_a0, alpha_i0 and beta_i0, in order to scale all transition rates in the Kv1.4 model. 

Effect of I_Kv4.3 current density on canine action potential shape and duration (1 Hz steady-state). Action potentials simulated with the WRJ canine ventricular cell model with increasing values of G_Kv4.3. (file: circres00_fig5a.par)

Effects of I_Kv4.3 current density on canine action potential, open probability of the L-type Ca²⁺ channel and L-type Ca²⁺ current magnitude.  (file: circres00_fig6.par)

The model is implemented so that two different conditions, normal and congestive heart failure (CHF), can be simulated by toggling a switch. An example is given here of the action potential at normal and CHF conditions. (file: ap_chf.par)