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Hudgkin-Huxley

Beeler-Reuler  

Luo-Rudy

Winslow-RJG

Michailova-McCulloch

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Winslow-Rice-Jafri-Greenstein Model

Description | Equations | Implementation | Examples | Discussion

Model Implementation

Two models are implemented: one is for I_to1 alone, and the other integrates the I_to1 channel model into a cell model (WRJ3). The implementation of the two models is based on the above two papers and the integrative cell model corresponds to the Version 3 of the Canine Ventricular Cell Model originally developed at Dr. Raimond Winslow's laboratory. NSR wrote model description files (ito1.mod and wrj3.mod) containing the published equations, model parameter values, and initial conditions. The WRJ3 model program was then generated automatically with the new java-based model simulation environment, JSIM (Currently, the runtime model control interface is  XSIM, which allows users  to control parameter values, result display, data analysis, sensitivity analysis, etc at runtime). JSIM recognizes the ODE(s) and selects a solver for solving the ODE(s) (DOPRI5, a robust, reliable solver for ODE(s) and RADAU for solving the stiff equations). JSIM selects RADAU for solving the stiff ODE(s).

Free  download of the models & modeling software is available. Models can also be run via the Internet.