Tabel of Contents

• GENTEX Overview
• What Is GENTEX?
• Vascular Components
• Nonexchaning vessels
• Capillary-tissue units
• Additional Features
• Input function generation
• Heterogeneity
• Parameter tools
• Summary
• GENTEX Tutorial
• Getting Started
• Overview
• The XSIM simulation interface
• Setting up a XSIM environment
• Running the GENTEX model
• Summary
• Basic Exercises
• Overview
• Generating an input function
• Configuring the model
• Selecting results for display
• Summary
• Basic Indicator Dilution Principles
• Overview
• Mean transit time
• Membrane conductances
• The effect of cells on indicator dilution curves
• Selecting an appropriate input function
• Summary
• Advanced Exercises
• Introduction
• The effect of tracer consumption
• The effect of flow heterogeneity
• The influence of nonexchanging vessels
• Summary
• Analysis Exercises
• Introduction
• Parameter optimization
• Using deconvolution to generate an input function
• Working with noisy data
• Summary
• GENTEX Reference
• Overview
• Model structure
• GENTEX, XSIM and the parameters
• Using the GENTEX reference
• Input Functions
• General
• Using reference data curves
• Using deconvolution to generate a vascular tracer input curve
• Using the function generator to generate a tracer input curve
• Input function errors and messages
• Heterogeneity for MMID4, MSID4 and GENTEX
• General
• Flow Heterogeneity
• Heterogeneous membrane conductances and consumption
• Heterogeneity errors and messages
• Blood and BTEX Operators
• Introduction
• Blood operators
• BTEX operators
• Transport and chemical reactions of permeant species in BTEX units
• Model switches
• Vascular and BTEX operator errors and messages
• Reference tables for GENTEX parameters
• Displaying Results
• Introduction
• Heterogeneity results
• Tracer and nontracer concentrations
• Tissue contents (residues)
• Residuals
• Parameter expressions and scalars
• Errors and messages
• Summary

Appendix A     GENTEX Tutorial Database Contents

Appendix B     Plots from Selected Tutorial Exercises