// This model generated automatically from SBML // unit definitions import nsrunit; unit conversion off; // SBML property definitions property sbmlRole=string; property sbmlName=string; property sbmlCompartment=string; // SBML reactions // Reaction1: EmptySet <=> Perm // Reaction2: Perm <=> EmptySet // Reaction3: EmptySet <=> Timm // Reaction4: Timm <=> EmptySet // Reaction5: EmptySet <=> Clkm // Reaction6: Clkm <=> EmptySet // Reaction7: CCc <=> CCn // Reaction8: CCn <=> CCc // Reaction9: PTn <=> PTc // Reaction10: PTc <=> PTn // Reaction11: species_0000012 Clkc => CCc // Reaction12: Perc Timc => PTc // Reaction16: EmptySet <=> Timc // Reaction18: EmptySet <=> Clkc // Reaction19: EmptySet <=> Perc // Reaction20: Perc <=> EmptySet // Reaction21: PTc <=> EmptySet // Reaction23: PTn <=> EmptySet // Reaction24: CCc <=> EmptySet // Reaction25: Clkc <=> EmptySet // Reaction26: CCn <=> EmptySet // Reaction27: Timc <=> EmptySet // Reaction28: Perm <=> EmptySet // Reaction29: Perc <=> EmptySet // Reaction30: Timm <=> EmptySet // Reaction31: Timc <=> EmptySet // Reaction32: PTc <=> EmptySet // Reaction33: PTn <=> EmptySet // Reaction34: Clkm <=> EmptySet // Reaction35: Clkc <=> EmptySet // Reaction36: CCc <=> EmptySet // Reaction37: CCn <=> EmptySet math main { realDomain time second; time.min=0; extern time.max; extern time.delta; // variable definitions real Drosophilia = 1 L; real compartment_0000003 = 1 L; real compartment_0000002 = 1 L; real EmptySet = 0 nM; real CCc(time) nM; real CCn(time) nM; real Clkc(time) nM; real Clkm(time) nM; real Perc(time) nM; real Perm(time) nM; real PTc(time) nM; real PTn(time) nM; real Timc(time) nM; real Timm(time) nM; real species_0000012 nM; real species_0000013 nM; real Reaction1(time) nmol/hr; real a = 1; real A1 = .45; real B1 = 0; real c1 = 0; real r1 = 1.02; real s1 = 1.45; real r = 4; real Reaction2(time) nmol/hr; real D0 = .012; real Reaction3(time) nmol/hr; real A2 = .45; real B2 = 0; real c2 = 0; real r2 = 1.02; real s3 = 1.45; real Reaction4(time) nmol/hr; real Reaction5(time) nmol/hr; real A3 = .8; real B3 = .6; real c3 = 0; real r3 = .89; real s5 = 1.63; real Reaction6(time) nmol/hr; real Reaction7(time) nmol/hr; real k3 = 2; real T3 = 1.63; real Reaction8(time) nmol/hr; real k4 = 2; real T4 = .52; real Reaction9(time) nmol/hr; real k2 = 2; real T2 = .72; real Reaction10(time) nmol/hr; real k1 = 2; real T1 = 1.73; real Reaction11(time) nmol/hr; real v3 = 1.63; real parameter_0000073 = 1.63; real Reaction12(time) nmol/hr; real v1 = 1.45; real parameter_0000072 = 1.45; real Reaction16(time) nmol/hr; real s4 = .48; real Reaction18(time) nmol/hr; real s6 = .47; real Reaction19(time) nmol/hr; real s2 = .48; real Reaction20(time) nmol/hr; real Reaction21(time) nmol/hr; real Reaction23(time) nmol/hr; real Reaction24(time) nmol/hr; real Reaction25(time) nmol/hr; real Reaction26(time) nmol/hr; real Reaction27(time) nmol/hr; real Reaction28(time) nmol/hr; real D1 = .94; real L1 = .3; real Reaction29(time) nmol/hr; real D2 = .44; real L2 = .2; real Reaction30(time) nmol/hr; real D3 = .94; real L3 = .3; real Reaction31(time) nmol/hr; real D4 = .44; real L4 = .2; real Reaction32(time) nmol/hr; real D5 = .44; real L5 = .2; real Reaction33(time) nmol/hr; real D6 = .29; real L6 = .2; real Reaction34(time) nmol/hr; real D7 = .54; real L7 = .13; real Reaction35(time) nmol/hr; real D8 = .6; real L8 = .2; real Reaction36(time) nmol/hr; real D9 = .6; real L9 = .2; real Reaction37(time) nmol/hr; real D10 = .3; real L10 = .2; // equations when (time=time.min) CCc = .3/compartment_0000003; CCc:time = (-1*Reaction7 + Reaction8 + Reaction11 + -1*Reaction24 + -1*Reaction36)/compartment_0000003; when (time=time.min) CCn = .4/compartment_0000002; CCn:time = (Reaction7 + -1*Reaction8 + -1*Reaction26 + -1*Reaction37)/compartment_0000002; when (time=time.min) Clkc = .2/compartment_0000003; Clkc:time = (-1*Reaction11 + Reaction18 + -1*Reaction25 + -1*Reaction35)/compartment_0000003; when (time=time.min) Clkm = .1/compartment_0000003; Clkm:time = (Reaction5 + -1*Reaction6 + -1*Reaction34)/compartment_0000003; when (time=time.min) Perc = .6/compartment_0000003; Perc:time = (-1*Reaction12 + Reaction19 + -1*Reaction20 + -1*Reaction29)/compartment_0000003; when (time=time.min) Perm = .5/compartment_0000003; Perm:time = (Reaction1 + -1*Reaction2 + -1*Reaction28)/compartment_0000003; when (time=time.min) PTc = .9/compartment_0000003; PTc:time = (Reaction9 + -1*Reaction10 + Reaction12 + -1*Reaction21 + -1*Reaction32)/compartment_0000003; when (time=time.min) PTn = 1/compartment_0000002; PTn:time = (-1*Reaction9 + Reaction10 + -1*Reaction23 + -1*Reaction33)/compartment_0000002; when (time=time.min) Timc = .8/compartment_0000003; Timc:time = (-1*Reaction12 + Reaction16 + -1*Reaction27 + -1*Reaction31)/compartment_0000003; when (time=time.min) Timm = .7/compartment_0000003; Timm:time = (Reaction3 + -1*Reaction4 + -1*Reaction30)/compartment_0000003; when (time=time.min) species_0000012 = 1/compartment_0000003; when (time=time.min) species_0000013 = 1/compartment_0000003; Reaction1 = compartment_0000003*(c1+(B1+(CCn/A1)^a)*s1/(1+B1+(CCn/A1)^a+(PTn/r1)^r)); Reaction2 = compartment_0000003*D0*Perm; Reaction3 = compartment_0000003*(c2+(B2+(CCn/A2)^a)*s3/(1+B2+(CCn/A2)^a+(PTn/r2)^r)); Reaction4 = Drosophilia*D0*Timm; Reaction5 = compartment_0000003*(c3+(B3+(PTn/A3)^a)*s5/(1+B3+(PTn/A3)^a+(CCn/r3)^r)); Reaction6 = Drosophilia*Clkm*D0; Reaction7 = compartment_0000003*(CCc*T3/(k3+CCc)); Reaction8 = compartment_0000002*(CCn*T4/(k4+CCn)); Reaction9 = compartment_0000002*(PTn*T2/(k2+PTn)); Reaction10 = compartment_0000003*(PTc*T1/(k1+PTc)); Reaction11 = compartment_0000003*(Clkc*v3*species_0000012-parameter_0000073*CCc); Reaction12 = compartment_0000003*(Perc*Timc*v1-parameter_0000072*PTc); Reaction16 = compartment_0000003*s4*Timm; Reaction18 = compartment_0000003*Clkm*s6; Reaction19 = compartment_0000003*s2*Perm; Reaction20 = Drosophilia*D0*Perc; Reaction21 = compartment_0000003*D0*PTc; Reaction23 = compartment_0000002*D0*PTn; Reaction24 = compartment_0000003*CCc*D0; Reaction25 = compartment_0000003*Clkc*D0; Reaction26 = compartment_0000002*CCn*D0; Reaction27 = compartment_0000003*D0*Timc; Reaction28 = compartment_0000003*(D1*Perm/(L1+Perm)); Reaction29 = compartment_0000003*(D2*species_0000013*Perc/(L2+Perc)); Reaction30 = compartment_0000003*(D3*Timm/(L3+Timm)); Reaction31 = compartment_0000003*(D4*Timc/(L4+Timc)); Reaction32 = compartment_0000003*(D5*PTc/(L5+PTc)); Reaction33 = compartment_0000002*(D6*PTn/(L6+PTn)); Reaction34 = compartment_0000003*(Clkm*D7/(Clkm+L7)); Reaction35 = compartment_0000003*(Clkc*D8/(Clkc+L8)); Reaction36 = compartment_0000003*(CCc*D9/(CCc+L9)); Reaction37 = compartment_0000002*(CCn*D10/(CCn+L10)); // variable properties Drosophilia.sbmlRole="compartment"; compartment_0000003.sbmlRole="compartment"; compartment_0000003.sbmlName="cytoplasm"; compartment_0000002.sbmlRole="compartment"; compartment_0000002.sbmlName="nucleus"; EmptySet.sbmlRole="species"; EmptySet.sbmlCompartment="Drosophilia"; CCc.sbmlRole="species"; CCc.sbmlCompartment="compartment_0000003"; CCn.sbmlRole="species"; CCn.sbmlCompartment="compartment_0000002"; Clkc.sbmlRole="species"; Clkc.sbmlCompartment="compartment_0000003"; Clkm.sbmlRole="species"; Clkm.sbmlCompartment="compartment_0000003"; Perc.sbmlRole="species"; Perc.sbmlCompartment="compartment_0000003"; Perm.sbmlRole="species"; Perm.sbmlCompartment="compartment_0000003"; PTc.sbmlRole="species"; PTc.sbmlCompartment="compartment_0000003"; PTn.sbmlRole="species"; PTn.sbmlCompartment="compartment_0000002"; Timc.sbmlRole="species"; Timc.sbmlCompartment="compartment_0000003"; Timm.sbmlRole="species"; Timm.sbmlCompartment="compartment_0000003"; species_0000012.sbmlRole="species"; species_0000012.sbmlCompartment="compartment_0000003"; species_0000013.sbmlRole="species"; species_0000013.sbmlCompartment="compartment_0000003"; Reaction1.sbmlRole="rate"; a.sbmlRole="parameter"; A1.sbmlRole="parameter"; B1.sbmlRole="parameter"; c1.sbmlRole="parameter"; c1.sbmlName="C1"; r1.sbmlRole="parameter"; r1.sbmlName="R1"; s1.sbmlRole="parameter"; s1.sbmlName="S1"; r.sbmlRole="parameter"; Reaction2.sbmlRole="rate"; D0.sbmlRole="parameter"; Reaction3.sbmlRole="rate"; A2.sbmlRole="parameter"; B2.sbmlRole="parameter"; c2.sbmlRole="parameter"; c2.sbmlName="C2"; r2.sbmlRole="parameter"; r2.sbmlName="R2"; s3.sbmlRole="parameter"; s3.sbmlName="S3"; Reaction4.sbmlRole="rate"; Reaction5.sbmlRole="rate"; A3.sbmlRole="parameter"; B3.sbmlRole="parameter"; c3.sbmlRole="parameter"; c3.sbmlName="C3"; r3.sbmlRole="parameter"; r3.sbmlName="R3"; s5.sbmlRole="parameter"; s5.sbmlName="S5"; Reaction6.sbmlRole="rate"; Reaction7.sbmlRole="rate"; k3.sbmlRole="parameter"; k3.sbmlName="K3"; T3.sbmlRole="parameter"; Reaction8.sbmlRole="rate"; k4.sbmlRole="parameter"; T4.sbmlRole="parameter"; Reaction9.sbmlRole="rate"; k2.sbmlRole="parameter"; k2.sbmlName="K2"; T2.sbmlRole="parameter"; Reaction10.sbmlRole="rate"; k1.sbmlRole="parameter"; k1.sbmlName="K1"; T1.sbmlRole="parameter"; Reaction11.sbmlRole="rate"; v3.sbmlRole="parameter"; v3.sbmlName="V3"; parameter_0000073.sbmlRole="parameter"; parameter_0000073.sbmlName="V4"; Reaction12.sbmlRole="rate"; v1.sbmlRole="parameter"; v1.sbmlName="V1"; parameter_0000072.sbmlRole="parameter"; parameter_0000072.sbmlName="V2"; Reaction16.sbmlRole="rate"; s4.sbmlRole="parameter"; s4.sbmlName="S4"; Reaction18.sbmlRole="rate"; s6.sbmlRole="parameter"; s6.sbmlName="S6"; Reaction19.sbmlRole="rate"; s2.sbmlRole="parameter"; s2.sbmlName="S2"; Reaction20.sbmlRole="rate"; Reaction21.sbmlRole="rate"; Reaction23.sbmlRole="rate"; Reaction24.sbmlRole="rate"; Reaction25.sbmlRole="rate"; Reaction26.sbmlRole="rate"; Reaction27.sbmlRole="rate"; Reaction28.sbmlRole="rate"; D1.sbmlRole="parameter"; L1.sbmlRole="parameter"; Reaction29.sbmlRole="rate"; D2.sbmlRole="parameter"; L2.sbmlRole="parameter"; Reaction30.sbmlRole="rate"; D3.sbmlRole="parameter"; L3.sbmlRole="parameter"; Reaction31.sbmlRole="rate"; D4.sbmlRole="parameter"; L4.sbmlRole="parameter"; Reaction32.sbmlRole="rate"; D5.sbmlRole="parameter"; L5.sbmlRole="parameter"; Reaction33.sbmlRole="rate"; D6.sbmlRole="parameter"; L6.sbmlRole="parameter"; Reaction34.sbmlRole="rate"; D7.sbmlRole="parameter"; L7.sbmlRole="parameter"; Reaction35.sbmlRole="rate"; D8.sbmlRole="parameter"; L8.sbmlRole="parameter"; Reaction36.sbmlRole="rate"; D9.sbmlRole="parameter"; L9.sbmlRole="parameter"; Reaction37.sbmlRole="rate"; D10.sbmlRole="parameter"; L10.sbmlRole="parameter"; }