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JSim CellML Models Page

This page allows users to run models from the CellML model archive under JSim. To run these models online, you must have a Java plugin installed in your WWW browser. To run them in JSim on your own computer, download the model code and the JSim application. Either way, see Running JSim for instructions on how to use JSim. Since CellML models do not specify simulation time length or delta, these must be set by the user before running the model.

Users are strongly advised to read Running CellML Models under JSim before running CellML models under JSim. The warning icon indicates that a unit conversion has been turned off because the model does not satisfy JSim unit balance.

Terms of use

Currently available models

adrian_chandler_hodgkin_1970
Voltage Clamp Experiments in Striated Muscle Fibres

albrecht_colegrove_friel_2002
Differential Regulation of ER Ca2+ Uptake and Release Rates Accounts for Multiple Modes of Ca2+-induced Ca2+ Release

albrecht_colegrove_hongpaisan_pivovarova_andrews_friel_2001
Multiple Modes of Calcium-induced Calcium Release in Sympathetic Neurons

aon_cortassa_2002
Modulation of a Metabolic Network by Cytoskeletal Organisation and Dynamics

asthagiri_lauffenburger_2001
Feedback Effects On Signal Dynamics In A Mitogen-Activated Protein Kinase (MAPK) Cascade

bakker_mensonides_teusink_vanhoek_michels_westerhoff_2000
Glycosomes Protect Trypanosomes from Glycolysis

bakker_michels_opperdoes_westerhoff_1997
Modelling Glycolysis in Trypanosoma brucei, Bakker et al, 1997

baylor_hollingworth_chandler_2002
Calcium Sparks in Skeletal Muscle Fibers

beard_2005
A Biophysical Model of the Mitochondrial Respiratory System and Oxidative Phosphorylation, Beard, 2005

beeler_reuter_1977
Beeler-Reuter Mammalian Ventricular Model 1977

bental_2006
Simplified Models For Gas Exchange In The Human Lungs

bernus_wilders_zemlin_verschelde_panfilov_2002
A Computationally Efficient Electrophysiological Model of Human Ventricular Cells

bertram_arnot_zamponi_2002
G-Protein Specificity In Synaptic Signalling

bertram_previte_sherman_kinard_satin_2000
The Phantom Burster Model For Pancreatic Beta-Cells

bertram_satin_pedersen_luciani_sherman_2007
Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets

bertram_satin_zhang_smolen_sherman_2004
Modelling Multiple Bursting Models in Pancreatic Islets

bertram_sherman_2004
A Calcium-based Phantom Bursting Model for Pancreatic Islets

bertram_smolen_sherman_mears_atwater_martin_soria_1995
Modulatory Role for CRAC in Pancreatic Beta-Cell Electrical Activity

bhalla_iyengar_1999
The Phospholipase 2A (PLA2) Pathway Model from Bhalla and Iyengar

bindschadler_sneyd_2001
A Bifurcation Analysis of Two Coupled Calcium Oscillators

bingzheng_zhenye_liansong_1990
A mathematical model of the regulation system of the secretion of glucocorticoids

bondarenko_szigeti_bett_kim_rasmusson_2004
Modelling the Action Potential of Mouse Ventricular Myocytes

bonhoeffer_rembiszewski_ortiz_nixon_2000
Modelling the Population Dynamics of Virus Infected Cells

boyett_zhang_garny_holden_2001
Modelling The Effect Of Intracellular Ca2+ On Sinoatrial Node Action Potentials, 2001

brown_choe_shanahan_czeisler_1997
A mathematical model of diurnal variations in human plasma melatonin levels

bueno_2007
Model Status

butera_rinzel_smith_1999
Models Of Respiratory Rhythm Generation In The Pre-Botzinger Complex. I. Bursting Pacemaker Neurons

campbell_chandra_2006
Function of Stretch Activation in Heart Muscle

cartwright_husain_1986
A model for the control of testosterone secretion

chang_fujita_1999
A Kinetic Model of the Thiazide-Sensitive Na-Cl Cotransporter

chang_fujita_2001
Mathematical Models of Ionic Transport in the Distal Tubule of the Rat

chassagnole_rais_quentin_fell_mazat_2001
The Threonine-Synthesis Pathway In Escherichia coli

chay_1997
Extracellular And Intracellular Calcium Effects On Pancreatic Beta-Cells

chay_lee_fan_1995
Intracellular Ca2+ Spikes in Non-excitable Cell Models

chen_calzone_csikasznagy_cross_novak_tyson_2004
An Integrative Analysis of Cell Cycle Control in Budding Yeast

chen_csikasz-nagy_gyorffy_val_novak_tyson_2000
Modelling the Budding Yeast Cell Cycle

chen_popel_2006
Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells

chen_popel_2007
Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3)

cheng_brown_loeb_2000
Virtual muscle: a computational approach to understanding the effects of muscle properties on motor control

ciliberto_novak_tyson_2003
Modelling the Morphogenesis Checkpoint in the Budding Yeast Cell Cycle

ciliberto_petrus_tyson_sible_2003
A Kinetic Model of the Cyclin E/Cdk2 Developmental Timer in Xenopus laevis embryos

ciliberto_tyson_2000
Mathematical Model for the Early Development of the Sea Urchin Embryo

clancy_rudy_2001
Clancy-Rudy Markovian Model of Ion Channels 2001

clancy_rudy_2002
A Single Mutation Underlies Brugada and LQT

colegrove_albrecht_friel_2000
Quantitative Analysis Of Mitochondrial Ca2+ Uptake And Release Pathways In Sympathetic Neurons

cooling_hunter_crampin_2007
Modelling Hypertrophic IP3 Transients in the Cardiac Myocyte

cooling_hunter_crampin_CAN_2008
Calcineurin Regulation: Insights from Kinetic Modelling

cooling_hunter_crampin_CellML_2008
NFAT Cycling Calcium Sensitivity: A Quantitative Myocyte Model

cooling_hunter_crampin_NFAT_2008
NFAT Cycling Calcium Sensitivity: A Quantitative Myocyte Model

corrias_buist_2007
A quantitative model of gastric smooth muscle cellular activation

corrias_buist_2008

cortassa_aon_marban_winslow_orourke_2003
Modelling Mitochondrial Energy Metabolism

cortassa_aon_winslow_orourke_2004
Modelling Mitochondrial Energy Metabolism

costa_holmes_mcculloch_2001
The Guccione Constitutive Material Law

courtemanche_ramirez_nattel_1998
Mathematical Model Of A Human Atrial Action Potential, 1998

cronwright_rohwer_prior_2002
Metabolic Control Analysis of Glycerol Synthesis in Saccharomyces cerevisiae

cui_kaandorp_2006
Mathematical modelling of calcium homeostasis in yeast cells

cui_kaandorp_2008

curien_ravanel_dumas_2003
A Kinetic Model of the Branch-Point between the Methionine and Threonine Biosynthesis Pathways in Arabidopsis thaliana

dash_bassingthwaighte_2004
Blood HbO2 and HbCO2 Dissociation Curves at Varies O2, CO2, pH, 2,3-DPG and Temperature Levels

dawson_lea_irvine_2003
Kinetic Model of the Inositol Trisphosphate Receptor

demir_clark_giles_1999
A Model Of Parasympathetic Modulation Of Pacemaker Rate, 1999

demir_clark_giles_murphey_1994
A Mathematical Model Of A Rabbit Sinoatrial Node Cell, 1994

demiray_1981
Exponential Constitutive Material Law

dempsher_gann_phair_1984
A mechanistic model of ACTH-stimulated cortisol secretion

depaor_timmons_1986
A feedback oscillator model for circulatory autoregulation

devries_sherman_2000
Enhancement Of Emergent Bursting In Pancreatic Beta-Cells

devries_sherman_2001
From Spikers To Bursters Via Heterogeneity

deyoung_keizer_1992
IP3-Mediated Ca2+ Release

difrancesco_noble_1985
Di Francesco-Noble Purkinje Fibre Model 1985

dixit_perelson_2004
Modelling the Complex Patterns of Viral Load Decay under Antiretroviral Therapy

dokos_celler_lovell_1996
A Single Cell Mathematical Model of the Ion Currents Underlying Sinoatrial Node Pacemaker Activity

dougherty_wright_yew_2005
Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons

drouhard_roberge_1987
The Drouhard-Roberge Sodium Current Model (1987)

dumaine_towbin_brugada_vatta_nesterenko_nesterenko_brugada_brugada_antzelevitch_1999
Modelling the Ionic Mechanisms Underlying Brugada Syndrome

earm_noble_1990
Model Status

ebihara_johnson_1980
The Ebihara-Johnson Sodium Current Model (1980)

egli_bertram_sellix_freeman_2004
Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin

enciso_sontag_2004
On the stability of a model of testosterone dynamics

endresen_1996
Mathematical modeling and qualitative analysis of insulin therapies

espinosa_1998
Espinosa Model - healthy version

evans_errington_shelly_feeney_chapman_godfrey_smith_chappell_2004
Modelling The In Vitro Kinetics Of The Anti-Cancer Agent Topotecan

faber_rudy_2000
Updated Luo-Rudy Mammalian Ventricular Model II

fall_keizer_2001
Mitochondria And Ca2+ Signalling

fallon_lauffenburger_2000
Binding, Internalisation and Postendocytotic Sorting of Interleukin-2 and Its Receptor

farhy_bowers_veldhuis_2007
Modelling Growth Hormone Regulation in Humans

faville_pullan_sanders_smith_2008
A Biophysically Based Mathematical Model of Unitary Potential Activity in Interstitial Cells of Cajal