// This model generated automatically from SBML // WARNING: Renamed variable Jspn to J_spn due to JSim namespace restrictions // unit definitions import nsrunit; unit conversion off; // SBML property definitions property sbmlRole=string; property sbmlName=string; property sbmlCompartment=string; // SBML reactions // v1: s => MASS // v2: s => CLN2 // v3: CLN2 => p // v4: s => CLB2 // v5: s => CLB2 // v6: s => CLB2 // v7: CLB2 => p // v8: s => CLB5 // v9: s => CLB5 // v10: s => CLB5 // v11: CLB5 => p // v12: s => SIC1 // v13: s => SIC1 // v14: s => SIC1 // v15: s => SIC1 // v16: SIC1 => p // v17: s => CDC6 // v18: s => CDC6 // v19: s => CDC6 // v20: s => CDC6 // v21: CDC6 => p // v22: s => C2 // v23: s => C2 // v24: C2 => p // v25: s => C5 // v26: s => C5 // v27: C5 => p // v28: s => F2 // v29: s => F2 // v30: F2 => p // v31: s => F5 // v32: s => F5 // v33: F5 => p // v34: s => SIC1P // v35: SIC1P => p // v36: s => SIC1P // v37: s => SIC1P // v38: s => C2P // v39: C2P => p // v40: s => C5P // v41: C5P => p // v42: s => CDC6P // v43: CDC6P => p // v44: s => CDC6P // v45: s => CDC6P // v46: s => F2P // v47: F2P => p // v48: s => F5P // v49: F5P => p // v50: s => SWI5T SWI5 // v51: s => SWI5T SWI5 // v52: SWI5T => p // v53: s => SWI5 // v54: SWI5 => p // v55: s => IEP // v56: IEP => p // v57: s => CDC20T // v58: CDC20T => p // v59: s => CDC20 // v60: CDC20 => p // v61: s => CDH1T CDH1 // v62: CDH1T => p // v63: CDH1 => p // v64: s => CDH1 // v65: CDH1 => p // v66: s => CDC14T CDC14 // v67: CDC14T => p // v68: s => CDC14 // v69: CDC14 => p // v70: CDC14 => p // v71: s => CDC14 // v72: s => NET1T NET1 // v73: NET1T => p // v74: RENT => NET1 // v75: NET1 => RENT // v76: s => NET1 // v77: NET1 => p // v78: NET1 => p // v79: s => NET1 // v80: s => RENT // v81: RENT => p // v82: RENT => p // v83: s => TEM1 // v84: TEM1 => p // v85: s => CDC15 // v86: CDC15 => p // v87: s => PPX // v88: PPX => p // v89: s => PDS1 // v90: s => PDS1 // v91: PDS1 => p // v92: ESP1 => p // v93: s => ESP1 // v94: s => ORI // v95: ORI => p // v96: s => BUD // v97: BUD => p // v98: s => SPN // v99: SPN => p math main { realDomain time second; time.min=0; extern time.max; extern time.delta; // variable definitions real compartment = 1 L; real CLN3(time); real BCK2(time); real CLB5T(time); real CLB2T(time); real Vasbf(time); real SBF(time); real MCM1(time); real SIC1T(time); real CDC6T(time); real CKIT(time); real RENTP(time); real NET1P(time); real PE(time); real Vdb2(time); real Vdb5(time); real Vkpc1(time); real Vppc1(time); real Vkpf6(time); real Vppf6(time); real Vaiep(time); real Vacdh(time); real Vicdh(time); real Vppnet(time); real Vkpnet(time); real Vdpds(time); real Vdppx(time); real B0 = .054; real C0 = .4; real Dn3 = 1; real Jn3 = 6; real ksn2a = 0; real ksn2aa = .15; real kdn2 = .12; real dn2 = .12; real esbfn2 = 2; real esbfn3 = 10; real esbfb5 = 2; real kasbf = .38; real kisbfa = .6; real kisbfaa = 8; real Jasbf = .01; real Jisbf = .01; real ksb2a = .001; real ksb2aa = .04; real kdb2a = .003; real kdb2aa = .4; real kdb2p = .15; real kamcm = 1; real kimcm = .15; real Jamcm = .1; real Jimcm = .1; real ksb5a = 8E-4; real ksb5aa = .005; real kdb5a = .01; real kdb5aa = .16; real ksc1a = .012; real ksc1aa = .12; real kd1c1 = .01; real kd2c1 = 1; real Jd2c1 = .05; real ec1k2 = .03; real ec1n2 = .06; real ec1b5 = .1; real ec1b2 = .45; real ec1n3 = .3; real kasb2 = 50; real kdib2 = .05; real kasb5 = 50; real kdib5 = .06; real kd3c1 = 1; real kppc1 = 4; real ksf6a = .024; real ksf6aa = .12; real ksf6aaa = .004; real kd1f6 = .01; real kd2f6 = 1; real Jd2f6 = .05; real ef6k2 = .03; real ef6n2 = .06; real ef6b5 = .1; real ef6b2 = .55; real ef6n3 = .3; real kasf2 = 15; real kdif2 = .5; real kasf5 = .01; real kdif5 = .01; real kd3f6 = 1; real kppf6 = 4; real ksswia = .005; real ksswiaa = .08; real kdswi = .08; real kaswi = 2; real kiswi = .05; real kaiep = .1; real kiiep = .15; real Jaiep = .1; real Jiiep = .1; real ks20a = .006; real ks20aa = .6; real kd20 = .3; real ka20a = .05; real ka20aa = .2; real kscdh = .01; real kdcdh = .01; real kacdha = .01; real kacdhaa = .8; real Jicdh = .03; real Jacdh = .03; real kicdha = .001; real kicdhaa = .08; real eicdhn2 = .4; real eicdhn3 = .25; real eicdhb5 = 8; real eicdhb2 = 1.2; real ks14 = .2; real kd14 = .1; real ksnet = .084; real kdnet = .03; real kasrent = 200; real kasrentp = 1; real kdirent = 1; real kdirentp = 2; real kppneta = .05; real kppnetaa = 3; real kkpneta = .01; real kkpnetaa = .6; real kspdsa = 0; real ks1pdsaa = .03; real ks2pdsaa = .055; real kd1pdsa = .01; real kd2pdsaa = .2; real kd3pdsaa = .04; real kasesp = 50; real kdiesp = .5; real ESP1T = 1; real ksppx = .1; real Jpds = .04; real kdppxa = .17; real kdppxaa = 2; real J20ppx = .15; real ksori = 2; real kdori = .06; real eorib5 = .9; real eorib2 = .45; real ksbud = .2; real kdbud = .06; real ebudn2 = .25; real ebudn3 = .05; real ebudb5 = 1; real ksspn = .1; real kdspn = .06; real J_spn = .14; real TEM1T = 1; real Jatem = .1; real Jitem = .1; real CDC15T = 1; real ka15a = .002; real ka15aa = 1; real ka15p = .001; real ki15 = .5; real MorD = 1; real kg = .00770164; real lte1 = .1; real Bub2 = .2; real ki20 = .01; real s = 1 M; real MASS(time) M; real CLN2(time) M; real p = 1 M; real CLB2(time) M; real CLB5(time) M; real SIC1(time) M; real CDC6(time) M; real C2(time) M; real C5(time) M; real F2(time) M; real F5(time) M; real SIC1P(time) M; real C2P(time) M; real C5P(time) M; real CDC6P(time) M; real F2P(time) M; real F5P(time) M; real SWI5T(time) M; real SWI5(time) M; real IEP(time) M; real CDC20T(time) M; real CDC20(time) M; real CDH1T(time) M; real CDH1(time) M; real CDC14T(time) M; real CDC14(time) M; real NET1T(time) M; real NET1(time) M; real RENT(time) M; real TEM1(time) M; real CDC15(time) M; real PPX(time) M; real PDS1(time) M; real ESP1(time) M; real ORI(time) M; real BUD(time) M; real SPN(time) M; real v1(time) katal; real v2(time) katal; real v3(time) katal; real v4(time) katal; real v5(time) katal; real v6(time) katal; real v7(time) katal; real v8(time) katal; real v9(time) katal; real v10(time) katal; real v11(time) katal; real v12(time) katal; real v13(time) katal; real v14(time) katal; real v15(time) katal; real v16(time) katal; real v17(time) katal; real v18(time) katal; real v19(time) katal; real v20(time) katal; real v21(time) katal; real v22(time) katal; real v23(time) katal; real v24(time) katal; real v25(time) katal; real v26(time) katal; real v27(time) katal; real v28(time) katal; real v29(time) katal; real v30(time) katal; real v31(time) katal; real v32(time) katal; real v33(time) katal; real v34(time) katal; real v35(time) katal; real v36(time) katal; real v37(time) katal; real v38(time) katal; real v39(time) katal; real v40(time) katal; real v41(time) katal; real v42(time) katal; real v43(time) katal; real v44(time) katal; real v45(time) katal; real v46(time) katal; real v47(time) katal; real v48(time) katal; real v49(time) katal; real v50(time) katal; real v51(time) katal; real v52(time) katal; real v53(time) katal; real v54(time) katal; real v55(time) katal; real v56(time) katal; real v57(time) katal; real v58(time) katal; real v59(time) katal; real v60(time) katal; real v61(time) katal; real v62(time) katal; real v63(time) katal; real v64(time) katal; real v65(time) katal; real v66(time) katal; real v67(time) katal; real v68(time) katal; real v69(time) katal; real v70(time) katal; real v71(time) katal; real v72(time) katal; real v73(time) katal; real v74(time) katal; real v75(time) katal; real v76(time) katal; real v77(time) katal; real v78(time) katal; real v79(time) katal; real v80(time) katal; real v81(time) katal; real v82(time) katal; real v83(time) katal; real v84(time) katal; real v85(time) katal; real v86(time) katal; real v87(time) katal; real v88(time) katal; real v89(time) katal; real v90(time) katal; real v91(time) katal; real v92(time) katal; real v93(time) katal; real v94(time) katal; real v95(time) katal; real v96(time) katal; real v97(time) katal; real v98(time) katal; real v99(time) katal; private real G_call0(time); private real G_call1(time); // equations CLN3 = C0*Dn3*MASS/(Jn3+Dn3*MASS); BCK2 = B0*MASS; CLB5T = CLB5+C5+C5P+F5+F5P; CLB2T = CLB2+C2+C2P+F2+F2P; Vasbf = kasbf*(esbfn2*CLN2+esbfn3*(CLN3+BCK2)+esbfb5*CLB5); SBF = G_call0; MCM1 = G_call1; SIC1T = SIC1+C2+C5+SIC1P+C2P+C5P; CDC6T = CDC6+F2+F5+CDC6P+F2P+F5P; CKIT = SIC1T+CDC6T; RENTP = CDC14T-RENT-CDC14; NET1P = NET1T-NET1-CDC14T+CDC14; PE = ESP1T-ESP1; Vdb2 = kdb2a+kdb2aa*CDH1+kdb2p*CDC20; Vdb5 = kdb5a+kdb5aa*CDC20; Vkpc1 = kd1c1+kd2c1*(ec1n3*CLN3+ec1k2*BCK2+ec1n2*CLN2+ec1b2*CLB2+ec1b5*CLB5)/(Jd2c1+SIC1T); Vppc1 = kppc1*CDC14; Vkpf6 = kd1f6+kd2f6*(ef6n3*CLN3+ef6k2*BCK2+ef6n2*CLN2+ef6b2*CLB2+ef6b5*CLB5)/(Jd2f6+CDC6T); Vppf6 = kppf6*CDC14; Vaiep = kaiep*CLB2; Vacdh = kacdha+kacdhaa*CDC14; Vicdh = kicdha+kicdhaa*(eicdhn3*CLN3+eicdhn2*CLN2+eicdhb5*CLB5+eicdhb2*CLB2); Vppnet = kppneta+kppnetaa*PPX; Vkpnet = (kkpneta+kkpnetaa*CDC15)*MASS; Vdpds = kd1pdsa+kd2pdsaa*CDC20+kd3pdsaa*CDH1; Vdppx = kdppxa+kdppxaa*(J20ppx+CDC20)*Jpds/(Jpds+PDS1); when (time=time.min) MASS = 1.2060194; MASS:time = (v1)/compartment; when (time=time.min) CLN2 = .06525118; CLN2:time = (v2 + -1*v3)/compartment; when (time=time.min) CLB2 = .14692272; CLB2:time = (v4 + v5 + v6 + -1*v7)/compartment; when (time=time.min) CLB5 = .05180419; CLB5:time = (v8 + v9 + v10 + -1*v11)/compartment; when (time=time.min) SIC1 = .02287769; SIC1:time = (v12 + v13 + v14 + v15 + -1*v16)/compartment; when (time=time.min) CDC6 = .10758043; CDC6:time = (v17 + v18 + v19 + v20 + -1*v21)/compartment; when (time=time.min) C2 = .23840472; C2:time = (v22 + v23 + -1*v24)/compartment; when (time=time.min) C5 = .07008149; C5:time = (v25 + v26 + -1*v27)/compartment; when (time=time.min) F2 = .23605862; F2:time = (v28 + v29 + -1*v30)/compartment; when (time=time.min) F5 = 7.2451476E-5; F5:time = (v31 + v32 + -1*v33)/compartment; when (time=time.min) SIC1P = .00641016; SIC1P:time = (v34 + -1*v35 + v36 + v37)/compartment; when (time=time.min) C2P = .02403405; C2P:time = (v38 + -1*v39)/compartment; when (time=time.min) C5P = .00687831; C5P:time = (v40 + -1*v41)/compartment; when (time=time.min) CDC6P = .01548638; CDC6P:time = (v42 + -1*v43 + v44 + v45)/compartment; when (time=time.min) F2P = .02739385; F2P:time = (v46 + -1*v47)/compartment; when (time=time.min) F5P = 7.906332E-6; F5P:time = (v48 + -1*v49)/compartment; when (time=time.min) SWI5T = .97646028; SWI5T:time = (v50 + v51 + -1*v52)/compartment; when (time=time.min) SWI5 = .95616245; SWI5:time = (v50 + v51 + v53 + -1*v54)/compartment; when (time=time.min) IEP = .10153911; IEP:time = (v55 + -1*v56)/compartment; when (time=time.min) CDC20T = 1.91634; CDC20T:time = (v57 + -1*v58)/compartment; when (time=time.min) CDC20 = .44429654; CDC20:time = (v59 + -1*v60)/compartment; when (time=time.min) CDH1T = 1; CDH1T:time = (v61 + -1*v62)/compartment; when (time=time.min) CDH1 = .93049926; CDH1:time = (v61 + -1*v63 + v64 + -1*v65)/compartment; when (time=time.min) CDC14T = 2; CDC14T:time = (v66 + -1*v67)/compartment; when (time=time.min) CDC14 = .46834397; CDC14:time = (v66 + v68 + -1*v69 + -1*v70 + v71)/compartment; when (time=time.min) NET1T = 2.8; NET1T:time = (v72 + -1*v73)/compartment; when (time=time.min) NET1 = .01864562; NET1:time = (v72 + v74 + -1*v75 + v76 + -1*v77 + -1*v78 + v79)/compartment; when (time=time.min) RENT = 1.0495477; RENT:time = (-1*v74 + v75 + v80 + -1*v81 + -1*v82)/compartment; when (time=time.min) TEM1 = .90389693; TEM1:time = (v83 + -1*v84)/compartment; when (time=time.min) CDC15 = .65653294; CDC15:time = (v85 + -1*v86)/compartment; when (time=time.min) PPX = .1231789; PPX:time = (v87 + -1*v88)/compartment; when (time=time.min) PDS1 = .02561235; PDS1:time = (v89 + v90 + -1*v91)/compartment; when (time=time.min) ESP1 = .30131334; ESP1:time = (-1*v92 + v93)/compartment; when (time=time.min) ORI = 9.0945256E-4; ORI:time = (v94 + -1*v95)/compartment; when (time=time.min) BUD = .00847345; BUD:time = (v96 + -1*v97)/compartment; when (time=time.min) SPN = .03056219; SPN:time = (v98 + -1*v99)/compartment; v1 = kg*MASS; v2 = (ksn2a+ksn2aa*SBF)*MASS; v3 = kdn2*CLN2; v4 = (ksb2a+ksb2aa*MCM1)*MASS; v5 = kd3c1*C2P+kd3f6*F2P; v6 = kdib2*C2+kdif2*F2; v7 = (Vdb2+kasb2*SIC1+kasf2*CDC6)*CLB2; v8 = (ksb5a+ksb5aa*SBF)*MASS; v9 = kd3c1*C5P+kd3f6*F5P; v10 = kdib5*C5+kdif5*F5; v11 = (Vdb5+kasb5*SIC1+kasf5*CDC6)*CLB5; v12 = ksc1a+ksc1aa*SWI5; v13 = Vdb2*C2+Vdb5*C5; v14 = kdib2*C2+kdib5*C5; v15 = Vppc1*SIC1P; v16 = (kasb2*CLB2+kasb5*CLB5+Vkpc1)*SIC1; v17 = ksf6a+ksf6aa*SWI5+ksf6aaa*SBF; v18 = Vdb2*F2+Vdb5*F5; v19 = kdif2*F2+kdif5*F5; v20 = Vppf6*CDC6P; v21 = (kasf2*CLB2+kasf5*CLB5+Vkpf6)*CDC6; v22 = kasb2*CLB2*SIC1; v23 = Vppc1*C2P; v24 = (kdib2+Vdb2+Vkpc1)*C2; v25 = kasb5*CLB5*SIC1; v26 = Vppc1*C5P; v27 = (kdib5+Vdb5+Vkpc1)*C5; v28 = kasf2*CLB2*CDC6; v29 = Vppf6*F2P; v30 = (kdif2+Vdb2+Vkpf6)*F2; v31 = kasf5*CLB5*CDC6; v32 = Vppf6*F5P; v33 = (kdif5+Vdb5+Vkpf6)*F5; v34 = Vkpc1*SIC1; v35 = (Vppc1+kd3c1)*SIC1P; v36 = Vdb2*C2P; v37 = Vdb5*C5P; v38 = Vkpc1*C2; v39 = (Vppc1+kd3c1+Vdb2)*C2P; v40 = Vkpc1*C5; v41 = (Vppc1+kd3c1+Vdb5)*C5P; v42 = Vkpf6*CDC6; v43 = (Vppf6+kd3f6)*CDC6P; v44 = Vdb2*F2P; v45 = Vdb5*F5P; v46 = Vkpf6*F2; v47 = (Vppf6+kd3f6+Vdb2)*F2P; v48 = Vkpf6*F5; v49 = (Vppf6+kd3f6+Vdb5)*F5P; v50 = ksswia; v51 = ksswiaa*MCM1; v52 = kdswi*SWI5T; v53 = kaswi*CDC14*(SWI5T-SWI5); v54 = (kiswi*CLB2+kdswi)*SWI5; v55 = Vaiep*(1-IEP)/(Jaiep+1-IEP); v56 = kiiep*IEP/(Jiiep+IEP); v57 = ks20a+ks20aa*MCM1; v58 = kd20*CDC20T; v59 = (ka20a+ka20aa*IEP)*(CDC20T-CDC20); v60 = (ki20+kd20)*CDC20; v61 = kscdh; v62 = kdcdh*CDH1T; v63 = kdcdh*CDH1; v64 = Vacdh*(CDH1T-CDH1)/(Jacdh+CDH1T-CDH1); v65 = Vicdh*CDH1/(Jicdh+CDH1); v66 = ks14; v67 = kd14*CDC14T; v68 = kdirent*RENT+kdirentp*RENTP; v69 = (kasrent*NET1+kasrentp*NET1P)*CDC14; v70 = kd14*CDC14; v71 = kdnet*(RENT+RENTP); v72 = ksnet; v73 = kdnet*NET1T; v74 = kdirent*RENT; v75 = kasrent*NET1*CDC14; v76 = Vppnet*NET1P; v77 = Vkpnet*NET1; v78 = kdnet*NET1; v79 = kd14*RENT; v80 = Vppnet*RENTP; v81 = Vkpnet*RENT; v82 = (kd14+kdnet)*RENT; v83 = lte1*(TEM1T-TEM1)/(Jatem+TEM1T-TEM1); v84 = Bub2*TEM1/(Jitem+TEM1); v85 = (ka15a*(TEM1T-TEM1)+ka15aa*TEM1+ka15p*CDC14)*(CDC15T-CDC15); v86 = ki15*CDC15; v87 = ksppx; v88 = Vdppx*PPX; v89 = kspdsa+ks1pdsaa*SBF+ks2pdsaa*MCM1; v90 = kdiesp*PE; v91 = (Vdpds+kasesp*ESP1)*PDS1; v92 = kasesp*PDS1*ESP1; v93 = (kdiesp+Vdpds)*PE; v94 = ksori*(eorib5*CLB5+eorib2*CLB2); v95 = kdori*ORI; v96 = ksbud*(ebudn2*CLN2+ebudn3*CLN3+ebudb5*CLB5); v97 = kdbud*BUD; v98 = ksspn*CLB2/(J_spn+CLB2); v99 = kdspn*SPN; G_call0 = 2*Vasbf*Jisbf/(kisbfa+kisbfaa*CLB2-Vasbf+(kisbfa+kisbfaa*CLB2)*Jasbf+Vasbf*Jisbf+((kisbfa+kisbfaa*CLB2-Vasbf+(kisbfa+kisbfaa*CLB2)*Jasbf+Vasbf*Jisbf)^2-4*Vasbf*Jisbf*(kisbfa+kisbfaa*CLB2-Vasbf))^(1/2)); G_call1 = 2*(kamcm*CLB2)*Jimcm/(kimcm-kamcm*CLB2+kimcm*Jamcm+kamcm*CLB2*Jimcm+((kimcm-kamcm*CLB2+kimcm*Jamcm+kamcm*CLB2*Jimcm)^2-4*(kamcm*CLB2)*Jimcm*(kimcm-kamcm*CLB2))^(1/2)); // Used function definitions // Function definition G(a,b,c,d)=2*a*d/(b-a+b*c+a*d+((b-a+b*c+a*d)^2-4*a*d*(b-a))^(1/2)); // variable properties compartment.sbmlRole="compartment"; CLN3.sbmlRole="parameter"; BCK2.sbmlRole="parameter"; CLB5T.sbmlRole="parameter"; CLB2T.sbmlRole="parameter"; Vasbf.sbmlRole="parameter"; SBF.sbmlRole="parameter"; MCM1.sbmlRole="parameter"; SIC1T.sbmlRole="parameter"; CDC6T.sbmlRole="parameter"; CKIT.sbmlRole="parameter"; RENTP.sbmlRole="parameter"; NET1P.sbmlRole="parameter"; PE.sbmlRole="parameter"; Vdb2.sbmlRole="parameter"; Vdb5.sbmlRole="parameter"; Vkpc1.sbmlRole="parameter"; Vppc1.sbmlRole="parameter"; Vkpf6.sbmlRole="parameter"; Vppf6.sbmlRole="parameter"; Vaiep.sbmlRole="parameter"; Vacdh.sbmlRole="parameter"; Vicdh.sbmlRole="parameter"; Vppnet.sbmlRole="parameter"; Vkpnet.sbmlRole="parameter"; Vdpds.sbmlRole="parameter"; Vdppx.sbmlRole="parameter"; B0.sbmlRole="parameter"; C0.sbmlRole="parameter"; Dn3.sbmlRole="parameter"; Jn3.sbmlRole="parameter"; ksn2a.sbmlRole="parameter"; ksn2aa.sbmlRole="parameter"; kdn2.sbmlRole="parameter"; dn2.sbmlRole="parameter"; esbfn2.sbmlRole="parameter"; esbfn3.sbmlRole="parameter"; esbfb5.sbmlRole="parameter"; kasbf.sbmlRole="parameter"; kisbfa.sbmlRole="parameter"; kisbfaa.sbmlRole="parameter"; Jasbf.sbmlRole="parameter"; Jisbf.sbmlRole="parameter"; ksb2a.sbmlRole="parameter"; ksb2aa.sbmlRole="parameter"; kdb2a.sbmlRole="parameter"; kdb2aa.sbmlRole="parameter"; kdb2p.sbmlRole="parameter"; kamcm.sbmlRole="parameter"; kimcm.sbmlRole="parameter"; Jamcm.sbmlRole="parameter"; Jimcm.sbmlRole="parameter"; ksb5a.sbmlRole="parameter"; ksb5aa.sbmlRole="parameter"; kdb5a.sbmlRole="parameter"; kdb5aa.sbmlRole="parameter"; ksc1a.sbmlRole="parameter"; ksc1aa.sbmlRole="parameter"; kd1c1.sbmlRole="parameter"; kd2c1.sbmlRole="parameter"; Jd2c1.sbmlRole="parameter"; ec1k2.sbmlRole="parameter"; ec1n2.sbmlRole="parameter"; ec1b5.sbmlRole="parameter"; ec1b2.sbmlRole="parameter"; ec1n3.sbmlRole="parameter"; kasb2.sbmlRole="parameter"; kdib2.sbmlRole="parameter"; kasb5.sbmlRole="parameter"; kdib5.sbmlRole="parameter"; kd3c1.sbmlRole="parameter"; kppc1.sbmlRole="parameter"; ksf6a.sbmlRole="parameter"; ksf6aa.sbmlRole="parameter"; ksf6aaa.sbmlRole="parameter"; kd1f6.sbmlRole="parameter"; kd2f6.sbmlRole="parameter"; Jd2f6.sbmlRole="parameter"; ef6k2.sbmlRole="parameter"; ef6n2.sbmlRole="parameter"; ef6b5.sbmlRole="parameter"; ef6b2.sbmlRole="parameter"; ef6n3.sbmlRole="parameter"; kasf2.sbmlRole="parameter"; kdif2.sbmlRole="parameter"; kasf5.sbmlRole="parameter"; kdif5.sbmlRole="parameter"; kd3f6.sbmlRole="parameter"; kppf6.sbmlRole="parameter"; ksswia.sbmlRole="parameter"; ksswiaa.sbmlRole="parameter"; kdswi.sbmlRole="parameter"; kaswi.sbmlRole="parameter"; kiswi.sbmlRole="parameter"; kaiep.sbmlRole="parameter"; kiiep.sbmlRole="parameter"; Jaiep.sbmlRole="parameter"; Jiiep.sbmlRole="parameter"; ks20a.sbmlRole="parameter"; ks20aa.sbmlRole="parameter"; kd20.sbmlRole="parameter"; ka20a.sbmlRole="parameter"; ka20aa.sbmlRole="parameter"; kscdh.sbmlRole="parameter"; kdcdh.sbmlRole="parameter"; kacdha.sbmlRole="parameter"; kacdhaa.sbmlRole="parameter"; Jicdh.sbmlRole="parameter"; Jacdh.sbmlRole="parameter"; kicdha.sbmlRole="parameter"; kicdhaa.sbmlRole="parameter"; eicdhn2.sbmlRole="parameter"; eicdhn3.sbmlRole="parameter"; eicdhb5.sbmlRole="parameter"; eicdhb2.sbmlRole="parameter"; ks14.sbmlRole="parameter"; kd14.sbmlRole="parameter"; ksnet.sbmlRole="parameter"; kdnet.sbmlRole="parameter"; kasrent.sbmlRole="parameter"; kasrentp.sbmlRole="parameter"; kdirent.sbmlRole="parameter"; kdirentp.sbmlRole="parameter"; kppneta.sbmlRole="parameter"; kppnetaa.sbmlRole="parameter"; kkpneta.sbmlRole="parameter"; kkpnetaa.sbmlRole="parameter"; kspdsa.sbmlRole="parameter"; ks1pdsaa.sbmlRole="parameter"; ks2pdsaa.sbmlRole="parameter"; kd1pdsa.sbmlRole="parameter"; kd2pdsaa.sbmlRole="parameter"; kd3pdsaa.sbmlRole="parameter"; kasesp.sbmlRole="parameter"; kdiesp.sbmlRole="parameter"; ESP1T.sbmlRole="parameter"; ksppx.sbmlRole="parameter"; Jpds.sbmlRole="parameter"; kdppxa.sbmlRole="parameter"; kdppxaa.sbmlRole="parameter"; J20ppx.sbmlRole="parameter"; ksori.sbmlRole="parameter"; kdori.sbmlRole="parameter"; eorib5.sbmlRole="parameter"; eorib2.sbmlRole="parameter"; ksbud.sbmlRole="parameter"; kdbud.sbmlRole="parameter"; ebudn2.sbmlRole="parameter"; ebudn3.sbmlRole="parameter"; ebudb5.sbmlRole="parameter"; ksspn.sbmlRole="parameter"; kdspn.sbmlRole="parameter"; J_spn.sbmlRole="parameter"; TEM1T.sbmlRole="parameter"; Jatem.sbmlRole="parameter"; Jitem.sbmlRole="parameter"; CDC15T.sbmlRole="parameter"; ka15a.sbmlRole="parameter"; ka15aa.sbmlRole="parameter"; ka15p.sbmlRole="parameter"; ki15.sbmlRole="parameter"; MorD.sbmlRole="parameter"; kg.sbmlRole="parameter"; lte1.sbmlRole="parameter"; Bub2.sbmlRole="parameter"; ki20.sbmlRole="parameter"; s.sbmlRole="species"; s.sbmlCompartment="compartment"; MASS.sbmlRole="species"; MASS.sbmlCompartment="compartment"; CLN2.sbmlRole="species"; CLN2.sbmlCompartment="compartment"; p.sbmlRole="species"; p.sbmlCompartment="compartment"; CLB2.sbmlRole="species"; CLB2.sbmlCompartment="compartment"; CLB5.sbmlRole="species"; CLB5.sbmlCompartment="compartment"; SIC1.sbmlRole="species"; SIC1.sbmlCompartment="compartment"; CDC6.sbmlRole="species"; CDC6.sbmlCompartment="compartment"; C2.sbmlRole="species"; C2.sbmlCompartment="compartment"; C5.sbmlRole="species"; C5.sbmlCompartment="compartment"; F2.sbmlRole="species"; F2.sbmlCompartment="compartment"; F5.sbmlRole="species"; F5.sbmlCompartment="compartment"; SIC1P.sbmlRole="species"; SIC1P.sbmlCompartment="compartment"; C2P.sbmlRole="species"; C2P.sbmlCompartment="compartment"; C5P.sbmlRole="species"; C5P.sbmlCompartment="compartment"; CDC6P.sbmlRole="species"; CDC6P.sbmlCompartment="compartment"; F2P.sbmlRole="species"; F2P.sbmlCompartment="compartment"; F5P.sbmlRole="species"; F5P.sbmlCompartment="compartment"; SWI5T.sbmlRole="species"; SWI5T.sbmlCompartment="compartment"; SWI5.sbmlRole="species"; SWI5.sbmlCompartment="compartment"; IEP.sbmlRole="species"; IEP.sbmlCompartment="compartment"; CDC20T.sbmlRole="species"; CDC20T.sbmlCompartment="compartment"; CDC20.sbmlRole="species"; CDC20.sbmlCompartment="compartment"; CDH1T.sbmlRole="species"; CDH1T.sbmlCompartment="compartment"; CDH1.sbmlRole="species"; CDH1.sbmlCompartment="compartment"; CDC14T.sbmlRole="species"; CDC14T.sbmlCompartment="compartment"; CDC14.sbmlRole="species"; CDC14.sbmlCompartment="compartment"; NET1T.sbmlRole="species"; NET1T.sbmlCompartment="compartment"; NET1.sbmlRole="species"; NET1.sbmlCompartment="compartment"; RENT.sbmlRole="species"; RENT.sbmlCompartment="compartment"; TEM1.sbmlRole="species"; TEM1.sbmlCompartment="compartment"; CDC15.sbmlRole="species"; CDC15.sbmlCompartment="compartment"; PPX.sbmlRole="species"; PPX.sbmlCompartment="compartment"; PDS1.sbmlRole="species"; PDS1.sbmlCompartment="compartment"; ESP1.sbmlRole="species"; ESP1.sbmlCompartment="compartment"; ORI.sbmlRole="species"; ORI.sbmlCompartment="compartment"; BUD.sbmlRole="species"; BUD.sbmlCompartment="compartment"; SPN.sbmlRole="species"; SPN.sbmlCompartment="compartment"; v1.sbmlRole="rate"; v2.sbmlRole="rate"; v3.sbmlRole="rate"; v4.sbmlRole="rate"; v5.sbmlRole="rate"; v6.sbmlRole="rate"; v7.sbmlRole="rate"; v8.sbmlRole="rate"; v9.sbmlRole="rate"; v10.sbmlRole="rate"; v11.sbmlRole="rate"; v12.sbmlRole="rate"; v13.sbmlRole="rate"; v14.sbmlRole="rate"; v15.sbmlRole="rate"; v16.sbmlRole="rate"; v17.sbmlRole="rate"; v18.sbmlRole="rate"; v19.sbmlRole="rate"; v20.sbmlRole="rate"; v21.sbmlRole="rate"; v22.sbmlRole="rate"; v23.sbmlRole="rate"; v24.sbmlRole="rate"; v25.sbmlRole="rate"; v26.sbmlRole="rate"; v27.sbmlRole="rate"; v28.sbmlRole="rate"; v29.sbmlRole="rate"; v30.sbmlRole="rate"; v31.sbmlRole="rate"; v32.sbmlRole="rate"; v33.sbmlRole="rate"; v34.sbmlRole="rate"; v35.sbmlRole="rate"; v36.sbmlRole="rate"; v37.sbmlRole="rate"; v38.sbmlRole="rate"; v39.sbmlRole="rate"; v40.sbmlRole="rate"; v41.sbmlRole="rate"; v42.sbmlRole="rate"; v43.sbmlRole="rate"; v44.sbmlRole="rate"; v45.sbmlRole="rate"; v46.sbmlRole="rate"; v47.sbmlRole="rate"; v48.sbmlRole="rate"; v49.sbmlRole="rate"; v50.sbmlRole="rate"; v51.sbmlRole="rate"; v52.sbmlRole="rate"; v53.sbmlRole="rate"; v54.sbmlRole="rate"; v55.sbmlRole="rate"; v56.sbmlRole="rate"; v57.sbmlRole="rate"; v58.sbmlRole="rate"; v59.sbmlRole="rate"; v60.sbmlRole="rate"; v61.sbmlRole="rate"; v62.sbmlRole="rate"; v63.sbmlRole="rate"; v64.sbmlRole="rate"; v65.sbmlRole="rate"; v66.sbmlRole="rate"; v67.sbmlRole="rate"; v68.sbmlRole="rate"; v69.sbmlRole="rate"; v70.sbmlRole="rate"; v71.sbmlRole="rate"; v72.sbmlRole="rate"; v73.sbmlRole="rate"; v74.sbmlRole="rate"; v75.sbmlRole="rate"; v76.sbmlRole="rate"; v77.sbmlRole="rate"; v78.sbmlRole="rate"; v79.sbmlRole="rate"; v80.sbmlRole="rate"; v81.sbmlRole="rate"; v82.sbmlRole="rate"; v83.sbmlRole="rate"; v84.sbmlRole="rate"; v85.sbmlRole="rate"; v86.sbmlRole="rate"; v87.sbmlRole="rate"; v88.sbmlRole="rate"; v89.sbmlRole="rate"; v90.sbmlRole="rate"; v91.sbmlRole="rate"; v92.sbmlRole="rate"; v93.sbmlRole="rate"; v94.sbmlRole="rate"; v95.sbmlRole="rate"; v96.sbmlRole="rate"; v97.sbmlRole="rate"; v98.sbmlRole="rate"; v99.sbmlRole="rate"; }