// This model generated automatically from SBML

// unit definitions
import nsrunit;
unit conversion off;

// SBML property definitions
property sbmlRole=string;
property sbmlName=string;
property sbmlCompartment=string;

// SBML reactions
// v1: s => MPF MPFtotal 
// v2: MPF => p 
// v3: s => MPF 
// v4: MPF => p 
// v5: MPFtotal => p 
// v6: s => Cdc20 
// v7: Cdc20 => p 
// v8: s => Cdc20 
// v9: Cdc20 APCP => APCPCdc20 
// v10: s => Mad2Cdc20P 
// v11: Mad2Cdc20P => p 
// v12: APCPCdc20 => p 
// v13: s => APCP 
// v14: APCP => p 
// v15: s => APCP 
// v16: s => Wee 
// v17: Wee => p 
// v18: s => Cdc25P 
// v19: Cdc25P => p 

math main {
  realDomain time second;
  time.min=0;
  extern time.max;
  extern time.delta;

  // variable definitions
  real compartment = 1 L;
  real kwee(time);
  real k25(time);
  real APC(time);
  real Cdc20P(time);
  real Mad2(time);
  real kcycsyn = .4;
  real kcycdeg = 2;
  real kacycdeg = .08;
  real kapcph = .04;
  real kapcdeph = .04;
  real k20deph = 8;
  real k20ph = 10;
  real kass = 80;
  real kdiss = 20;
  real kass2 = 10;
  real kdiss2 = .1;
  real ka25 = .2;
  real kaa25 = 10;
  real Vi25 = .2;
  real Vapa25 = 1;
  real kawee = .1;
  real kaawee = 4;
  real Vawee = .2;
  real Vaaiwee = 1;
  real Mad2active = .01;
  real APCtotal = 1;
  real Cdc20total = 1;
  real Cdc25total = 1;
  real Weetotal = 1;
  real Jwee = .01;
  real Jcycdeg = .01;
  real J25 = .01;
  real s = 1 M;
  real MPF(time) M;
  real MPFtotal(time) M;
  real p = 1 M;
  real Cdc20(time) M;
  real APCP(time) M;
  real APCPCdc20(time) M;
  real Mad2Cdc20P(time) M;
  real Wee(time) M;
  real Cdc25P(time) M;
  real v1(time) katal;
  real v2(time) katal;
  real v3(time) katal;
  real v4(time) katal;
  real v5(time) katal;
  real v6(time) katal;
  real v7(time) katal;
  real v8(time) katal;
  real v9(time) katal;
  real v10(time) katal;
  real v11(time) katal;
  real v12(time) katal;
  real v13(time) katal;
  real v14(time) katal;
  real v15(time) katal;
  real v16(time) katal;
  real v17(time) katal;
  real v18(time) katal;
  real v19(time) katal;

  // equations
  kwee = Weetotal*kawee+(kaawee-kawee)*Wee;
  k25 = Cdc25total*ka25+(kaa25-ka25)*Cdc25P;
  APC = APCtotal-APCP-APCPCdc20;
  Cdc20P = Cdc20total-Cdc20-APCPCdc20-Mad2Cdc20P;
  Mad2 = Mad2active-Mad2Cdc20P;
  when (time=time.min) MPF = .015;
  MPF:time = (v1 + -1*v2 + v3 + -1*v4)/compartment;
  when (time=time.min) MPFtotal = .016;
  MPFtotal:time = (v1 + -1*v5)/compartment;
  when (time=time.min) Cdc20 = .652;
  Cdc20:time = (v6 + -1*v7 + v8 + -1*v9)/compartment;
  when (time=time.min) APCP = .124;
  APCP:time = (-1*v9 + v13 + -1*v14 + v15)/compartment;
  when (time=time.min) APCPCdc20 = .32;
  APCPCdc20:time = (v9 + -1*v12)/compartment;
  when (time=time.min) Mad2Cdc20P = .009;
  Mad2Cdc20P:time = (v10 + -1*v11)/compartment;
  when (time=time.min) Wee = .718;
  Wee:time = (v16 + -1*v17)/compartment;
  when (time=time.min) Cdc25P = .281;
  Cdc25P:time = (v18 + -1*v19)/compartment;
  v1 = kcycsyn;
  v2 = kwee*MPF;
  v3 = k25*(MPFtotal-MPF);
  v4 = (kacycdeg+kcycdeg*(APCPCdc20/(Jcycdeg+MPFtotal)))*MPF;
  v5 = (kacycdeg+kcycdeg*(APCPCdc20/(Jcycdeg+MPFtotal)))*MPFtotal;
  v6 = k20deph*Cdc20P;
  v7 = k20ph*MPF*Cdc20;
  v8 = (kapcdeph+kdiss)*APCPCdc20;
  v9 = kass*Cdc20*APCP;
  v10 = kass2*Mad2*Cdc20P;
  v11 = kdiss2*Mad2Cdc20P;
  v12 = (kdiss+kapcdeph+k20ph*MPF)*APCPCdc20;
  v13 = kapcph*MPF*APC;
  v14 = kapcdeph*APCP;
  v15 = (kdiss+k20ph*MPF)*APCPCdc20;
  v16 = Vawee*((Weetotal-Wee)/(Jwee+Weetotal-Wee));
  v17 = Vaaiwee*MPF*Wee;
  v18 = Vapa25*MPF*(Cdc25total-Cdc25P);
  v19 = Vi25*Cdc25P/(J25+Cdc25P);

  // variable properties
  compartment.sbmlRole="compartment";
  kwee.sbmlRole="parameter";
  k25.sbmlRole="parameter";
  APC.sbmlRole="parameter";
  Cdc20P.sbmlRole="parameter";
  Mad2.sbmlRole="parameter";
  kcycsyn.sbmlRole="parameter";
  kcycdeg.sbmlRole="parameter";
  kacycdeg.sbmlRole="parameter";
  kapcph.sbmlRole="parameter";
  kapcdeph.sbmlRole="parameter";
  k20deph.sbmlRole="parameter";
  k20ph.sbmlRole="parameter";
  kass.sbmlRole="parameter";
  kdiss.sbmlRole="parameter";
  kass2.sbmlRole="parameter";
  kdiss2.sbmlRole="parameter";
  ka25.sbmlRole="parameter";
  kaa25.sbmlRole="parameter";
  Vi25.sbmlRole="parameter";
  Vapa25.sbmlRole="parameter";
  kawee.sbmlRole="parameter";
  kaawee.sbmlRole="parameter";
  Vawee.sbmlRole="parameter";
  Vaaiwee.sbmlRole="parameter";
  Mad2active.sbmlRole="parameter";
  APCtotal.sbmlRole="parameter";
  Cdc20total.sbmlRole="parameter";
  Cdc25total.sbmlRole="parameter";
  Weetotal.sbmlRole="parameter";
  Jwee.sbmlRole="parameter";
  Jcycdeg.sbmlRole="parameter";
  J25.sbmlRole="parameter";
  s.sbmlRole="species";
  s.sbmlCompartment="compartment";
  MPF.sbmlRole="species";
  MPF.sbmlCompartment="compartment";
  MPFtotal.sbmlRole="species";
  MPFtotal.sbmlCompartment="compartment";
  p.sbmlRole="species";
  p.sbmlCompartment="compartment";
  Cdc20.sbmlRole="species";
  Cdc20.sbmlCompartment="compartment";
  APCP.sbmlRole="species";
  APCP.sbmlCompartment="compartment";
  APCPCdc20.sbmlRole="species";
  APCPCdc20.sbmlCompartment="compartment";
  Mad2Cdc20P.sbmlRole="species";
  Mad2Cdc20P.sbmlCompartment="compartment";
  Wee.sbmlRole="species";
  Wee.sbmlCompartment="compartment";
  Cdc25P.sbmlRole="species";
  Cdc25P.sbmlCompartment="compartment";
  v1.sbmlRole="rate";
  v2.sbmlRole="rate";
  v3.sbmlRole="rate";
  v4.sbmlRole="rate";
  v5.sbmlRole="rate";
  v6.sbmlRole="rate";
  v7.sbmlRole="rate";
  v8.sbmlRole="rate";
  v9.sbmlRole="rate";
  v10.sbmlRole="rate";
  v11.sbmlRole="rate";
  v12.sbmlRole="rate";
  v13.sbmlRole="rate";
  v14.sbmlRole="rate";
  v15.sbmlRole="rate";
  v16.sbmlRole="rate";
  v17.sbmlRole="rate";
  v18.sbmlRole="rate";
  v19.sbmlRole="rate";
}