// This model generated automatically from SBML // unit definitions import nsrunit; unit conversion off; // SBML property definitions property sbmlRole=string; property sbmlName=string; property sbmlCompartment=string; // SBML reactions // R02147: Guanosine => Guanine // R02297: Xanthosine => Xanthine // R01049: D_minus_Ribose_space_5_minus_phosphate <=> space_5_minus_Phospho_minus_alpha_minus_D_minus_ribose_space_1_minus_diphosphate // R00086: ATP <=> ADP // R00127: AMP => ADP // R00376: dGTP => DNA // R01229: Guanine => GMP // R01561: Adenosine => Adenine // R00124: ADP => ATP // R03530: dIDP => dITP // R00441: GTP => RNA // R00435: ATP => RNA // R00183: AMP <=> Adenosine // R00200: ATP => ADP // R01858: dGTP <=> dGDP // R00089: ATP <=> space_3_space_space_5_space_minus_Cyclic_space_AMP // R00430: GTP => GDP // R02088: dAMP => Deoxyadenosine // R01857: dGDP => dGTP // R00330: GDP => GTP // R00434: GTP <=> space_3_space_space_5_space_minus_Cyclic_space_GMP // R00190: AMP => Adenine // R01227: GMP <=> Guanosine // R02719: Xanthosine_space_5_space_minus_phosphate <=> Xanthosine // R02017: dADP <=> ADP // R00509: Adenylyl_space_sulfate <=> space_3_space_minus_Phosphoadenylyl_space_sulfate // R01137: dADP => dATP // R01968: dGMP => Deoxyguanosine // R01547: dAMP => dADP // R01138: dATP => dADP // R00150: NH3 CO2 <=> Carbamoyl_space_phosphate // R01130: IMP => Xanthosine_space_5_space_minus_phosphate // R01054: ADP_minus_ribose <=> D_minus_Ribose_space_5_minus_phosphate // R00529: Sulfate <=> Adenylyl_space_sulfate // R00722: IDP => ITP // R02019: dGDP <=> GDP // R01863: Inosine => Hypoxanthine // R04378: space_1_minus_space_5_space_minus_Phosphoribosyl_space_minus_5_minus_amino_minus_4_minus_imidazolecarboxamide => space_5_minus_Amino_minus_4_minus_imidazolecarboxyamide // R02748: Deoxyinosine <=> Hypoxanthine // R01969: Deoxyguanosine => Guanine // R00375: dATP => DNA // R01126: IMP <=> Inosine // R02557: Adenine => Deoxyadenosine // R01230: Xanthosine_space_5_space_minus_phosphate <=> GMP math main { realDomain time second; time.min=0; extern time.max; extern time.delta; // variable definitions real default = 1 L; real uVol = 1 L; real E2_space_4_space_2_space_7 = 0 M; real E2_space_4_space_2_space_1 = 0 M; real E1_space_17_space_4_space_1 = 0 M; real E2_space_7_space_4_space_6 = 0 M; real E2_space_7_space_1_space_40 = 0 M; real E3_space_1_space_3_space_5 = 0 M; real E2_space_7_space_7_space_7 = 0 M; real E2_space_7_space_1_space_25 = 0 M; real E2_space_7_space_7_space_6 = 0 M; real E2_space_7_space_7_space_4 = 0 M; real E4_space_6_space_1_space_1 = 0 M; real E3_space_6_space_1_space_13 = 0 M; real E2_space_7_space_4_space_3 = 0 M; real E3_space_6_space_1_space_15 = 0 M; real E2_space_7_space_6_space_1 = 0 M; real E2_space_7_space_2_space_2 = 0 M; real E1_space_1_space_1_space_205 = 0 M; real E6_space_3_space_5_space_2 = 0 M; real GDP(time) M; real dGDP(time) M; real dGMP(time) M; real dIDP(time) M; real GTP(time) M; real dGTP(time) M; real dITP(time) M; real Deoxyguanosine(time) M; real Adenylyl_space_sulfate(time) M; real space_3_space_minus_Phosphoadenylyl_space_sulfate(time) M; real RNA(time) M; real Sulfate(time) M; real DNA(time) M; real space_3_space_space_5_space_minus_Cyclic_space_GMP(time) M; real Deoxyadenosine(time) M; real Deoxyinosine(time) M; real ATP(time) M; real dATP(time) M; real ADP_minus_ribose(time) M; real CO2(time) M; real ADP(time) M; real dADP(time) M; real dAMP(time) M; real D_minus_Ribose_space_5_minus_phosphate(time) M; real NH3(time) M; real space_5_minus_Phospho_minus_alpha_minus_D_minus_ribose_space_1_minus_diphosphate(time) M; real Carbamoyl_space_phosphate(time) M; real AMP(time) M; real Adenosine(time) M; real Adenine(time) M; real space_1_minus_space_5_space_minus_Phosphoribosyl_space_minus_5_minus_amino_minus_4_minus_imidazolecarboxamide(time) M; real IMP(time) M; real Inosine(time) M; real Hypoxanthine(time) M; real space_3_space_space_5_space_minus_Cyclic_space_AMP(time) M; real space_5_minus_Amino_minus_4_minus_imidazolecarboxyamide(time) M; real IDP(time) M; real Xanthosine_space_5_space_minus_phosphate(time) M; real Xanthosine(time) M; real Xanthine(time) M; real ITP(time) M; real GMP(time) M; real Guanosine(time) M; real Guanine(time) M; real R02147(time) katal; extern real R02147.kf; extern real R02147.kb; real R02297(time) katal; extern real R02297.kf; extern real R02297.kb; real R01049(time) katal; extern real R01049.kf; extern real R01049.kb; real R00086(time) katal; extern real R00086.kf; extern real R00086.kb; real R00127(time) katal; extern real R00127.kf; extern real R00127.kb; real R00376(time) katal; extern real R00376.kf; extern real R00376.kb; real R01229(time) katal; extern real R01229.kf; extern real R01229.kb; real R01561(time) katal; extern real R01561.kf; extern real R01561.kb; real R00124(time) katal; extern real R00124.kf; extern real R00124.kb; real R03530(time) katal; extern real R03530.kf; extern real R03530.kb; real R00441(time) katal; extern real R00441.kf; extern real R00441.kb; real R00435(time) katal; extern real R00435.kf; extern real R00435.kb; real R00183(time) katal; extern real R00183.kf; extern real R00183.kb; real R00200(time) katal; extern real R00200.kf; extern real R00200.kb; real R01858(time) katal; extern real R01858.kf; extern real R01858.kb; real R00089(time) katal; extern real R00089.kf; extern real R00089.kb; real R00430(time) katal; extern real R00430.kf; extern real R00430.kb; real R02088(time) katal; extern real R02088.kf; extern real R02088.kb; real R01857(time) katal; extern real R01857.kf; extern real R01857.kb; real R00330(time) katal; extern real R00330.kf; extern real R00330.kb; real R00434(time) katal; extern real R00434.kf; extern real R00434.kb; real R00190(time) katal; extern real R00190.kf; extern real R00190.kb; real R01227(time) katal; extern real R01227.kf; extern real R01227.kb; real R02719(time) katal; extern real R02719.kf; extern real R02719.kb; real R02017(time) katal; extern real R02017.kf; extern real R02017.kb; real R00509(time) katal; extern real R00509.kf; extern real R00509.kb; real R01137(time) katal; extern real R01137.kf; extern real R01137.kb; real R01968(time) katal; extern real R01968.kf; extern real R01968.kb; real R01547(time) katal; extern real R01547.kf; extern real R01547.kb; real R01138(time) katal; extern real R01138.kf; extern real R01138.kb; real R00150(time) katal; extern real R00150.kf; extern real R00150.kb; real R01130(time) katal; extern real R01130.kf; extern real R01130.kb; real R01054(time) katal; extern real R01054.kf; extern real R01054.kb; real R00529(time) katal; extern real R00529.kf; extern real R00529.kb; real R00722(time) katal; extern real R00722.kf; extern real R00722.kb; real R02019(time) katal; extern real R02019.kf; extern real R02019.kb; real R01863(time) katal; extern real R01863.kf; extern real R01863.kb; real R04378(time) katal; extern real R04378.kf; extern real R04378.kb; real R02748(time) katal; extern real R02748.kf; extern real R02748.kb; real R01969(time) katal; extern real R01969.kf; extern real R01969.kb; real R00375(time) katal; extern real R00375.kf; extern real R00375.kb; real R01126(time) katal; extern real R01126.kf; extern real R01126.kb; real R02557(time) katal; extern real R02557.kf; extern real R02557.kb; real R01230(time) katal; extern real R01230.kf; extern real R01230.kb; // equations when (time=time.min) GDP = 0; GDP:time = (R00430 + -1*R00330 + R02019)/uVol; when (time=time.min) dGDP = 0; dGDP:time = (R01858 + -1*R01857 + -1*R02019)/uVol; when (time=time.min) dGMP = 0; dGMP:time = (-1*R01968)/uVol; when (time=time.min) dIDP = 0; dIDP:time = (-1*R03530)/uVol; when (time=time.min) GTP = 0; GTP:time = (-1*R00441 + -1*R00430 + R00330 + -1*R00434)/uVol; when (time=time.min) dGTP = 0; dGTP:time = (-1*R00376 + -1*R01858 + R01857)/uVol; when (time=time.min) dITP = 0; dITP:time = (R03530)/uVol; when (time=time.min) Deoxyguanosine = 0; Deoxyguanosine:time = (R01968 + -1*R01969)/uVol; when (time=time.min) Adenylyl_space_sulfate = 0; Adenylyl_space_sulfate:time = (-1*R00509 + R00529)/uVol; when (time=time.min) space_3_space_minus_Phosphoadenylyl_space_sulfate = 0; space_3_space_minus_Phosphoadenylyl_space_sulfate:time = (R00509)/uVol; when (time=time.min) RNA = 0; RNA:time = (R00441 + R00435)/uVol; when (time=time.min) Sulfate = 0; Sulfate:time = (-1*R00529)/uVol; when (time=time.min) DNA = 0; DNA:time = (R00376 + R00375)/uVol; when (time=time.min) space_3_space_space_5_space_minus_Cyclic_space_GMP = 0; space_3_space_space_5_space_minus_Cyclic_space_GMP:time = (R00434)/uVol; when (time=time.min) Deoxyadenosine = 0; Deoxyadenosine:time = (R02088 + R02557)/uVol; when (time=time.min) Deoxyinosine = 0; Deoxyinosine:time = (-1*R02748)/uVol; when (time=time.min) ATP = 0; ATP:time = (-1*R00086 + R00124 + -1*R00435 + -1*R00200 + -1*R00089)/uVol; when (time=time.min) dATP = 0; dATP:time = (R01137 + -1*R01138 + -1*R00375)/uVol; when (time=time.min) ADP_minus_ribose = 0; ADP_minus_ribose:time = (-1*R01054)/uVol; when (time=time.min) CO2 = 0; CO2:time = (-1*R00150)/uVol; when (time=time.min) ADP = 0; ADP:time = (R00086 + R00127 + -1*R00124 + R00200 + R02017)/uVol; when (time=time.min) dADP = 0; dADP:time = (-1*R02017 + -1*R01137 + R01547 + R01138)/uVol; when (time=time.min) dAMP = 0; dAMP:time = (-1*R02088 + -1*R01547)/uVol; when (time=time.min) D_minus_Ribose_space_5_minus_phosphate = 0; D_minus_Ribose_space_5_minus_phosphate:time = (-1*R01049 + R01054)/uVol; when (time=time.min) NH3 = 0; NH3:time = (-1*R00150)/uVol; when (time=time.min) space_5_minus_Phospho_minus_alpha_minus_D_minus_ribose_space_1_minus_diphosphate = 0; space_5_minus_Phospho_minus_alpha_minus_D_minus_ribose_space_1_minus_diphosphate:time = (R01049)/uVol; when (time=time.min) Carbamoyl_space_phosphate = 0; Carbamoyl_space_phosphate:time = (R00150)/uVol; when (time=time.min) AMP = 0; AMP:time = (-1*R00127 + -1*R00183 + -1*R00190)/uVol; when (time=time.min) Adenosine = 0; Adenosine:time = (-1*R01561 + R00183)/uVol; when (time=time.min) Adenine = 0; Adenine:time = (R01561 + R00190 + -1*R02557)/uVol; when (time=time.min) space_1_minus_space_5_space_minus_Phosphoribosyl_space_minus_5_minus_amino_minus_4_minus_imidazolecarboxamide = 0; space_1_minus_space_5_space_minus_Phosphoribosyl_space_minus_5_minus_amino_minus_4_minus_imidazolecarboxamide:time = (-1*R04378)/uVol; when (time=time.min) IMP = 0; IMP:time = (-1*R01130 + -1*R01126)/uVol; when (time=time.min) Inosine = 0; Inosine:time = (-1*R01863 + R01126)/uVol; when (time=time.min) Hypoxanthine = 0; Hypoxanthine:time = (R01863 + R02748)/uVol; when (time=time.min) space_3_space_space_5_space_minus_Cyclic_space_AMP = 0; space_3_space_space_5_space_minus_Cyclic_space_AMP:time = (R00089)/uVol; when (time=time.min) space_5_minus_Amino_minus_4_minus_imidazolecarboxyamide = 0; space_5_minus_Amino_minus_4_minus_imidazolecarboxyamide:time = (R04378)/uVol; when (time=time.min) IDP = 0; IDP:time = (-1*R00722)/uVol; when (time=time.min) Xanthosine_space_5_space_minus_phosphate = 0; Xanthosine_space_5_space_minus_phosphate:time = (-1*R02719 + R01130 + -1*R01230)/uVol; when (time=time.min) Xanthosine = 0; Xanthosine:time = (-1*R02297 + R02719)/uVol; when (time=time.min) Xanthine = 0; Xanthine:time = (R02297)/uVol; when (time=time.min) ITP = 0; ITP:time = (R00722)/uVol; when (time=time.min) GMP = 0; GMP:time = (R01229 + -1*R01227 + R01230)/uVol; when (time=time.min) Guanosine = 0; Guanosine:time = (-1*R02147 + R01227)/uVol; when (time=time.min) Guanine = 0; Guanine:time = (R02147 + -1*R01229 + R01969)/uVol; R02147 = R02147.kf*Guanosine - R02147.kb*Guanine; R02297 = R02297.kf*Xanthosine - R02297.kb*Xanthine; R01049 = R01049.kf*D_minus_Ribose_space_5_minus_phosphate - R01049.kb*space_5_minus_Phospho_minus_alpha_minus_D_minus_ribose_space_1_minus_diphosphate; R00086 = R00086.kf*ATP - R00086.kb*ADP; R00127 = R00127.kf*AMP - R00127.kb*ADP; R00376 = R00376.kf*dGTP - R00376.kb*DNA; R01229 = R01229.kf*Guanine - R01229.kb*GMP; R01561 = R01561.kf*Adenosine - R01561.kb*Adenine; R00124 = R00124.kf*ADP - R00124.kb*ATP; R03530 = R03530.kf*dIDP - R03530.kb*dITP; R00441 = R00441.kf*GTP - R00441.kb*RNA; R00435 = R00435.kf*ATP - R00435.kb*RNA; R00183 = R00183.kf*AMP - R00183.kb*Adenosine; R00200 = R00200.kf*ATP - R00200.kb*ADP; R01858 = R01858.kf*dGTP - R01858.kb*dGDP; R00089 = R00089.kf*ATP - R00089.kb*space_3_space_space_5_space_minus_Cyclic_space_AMP; R00430 = R00430.kf*GTP - R00430.kb*GDP; R02088 = R02088.kf*dAMP - R02088.kb*Deoxyadenosine; R01857 = R01857.kf*dGDP - R01857.kb*dGTP; R00330 = R00330.kf*GDP - R00330.kb*GTP; R00434 = R00434.kf*GTP - R00434.kb*space_3_space_space_5_space_minus_Cyclic_space_GMP; R00190 = R00190.kf*AMP - R00190.kb*Adenine; R01227 = R01227.kf*GMP - R01227.kb*Guanosine; R02719 = R02719.kf*Xanthosine_space_5_space_minus_phosphate - R02719.kb*Xanthosine; R02017 = R02017.kf*dADP - R02017.kb*ADP; R00509 = R00509.kf*Adenylyl_space_sulfate - R00509.kb*space_3_space_minus_Phosphoadenylyl_space_sulfate; R01137 = R01137.kf*dADP - R01137.kb*dATP; R01968 = R01968.kf*dGMP - R01968.kb*Deoxyguanosine; R01547 = R01547.kf*dAMP - R01547.kb*dADP; R01138 = R01138.kf*dATP - R01138.kb*dADP; R00150 = R00150.kf*NH3*CO2 - R00150.kb*Carbamoyl_space_phosphate; R01130 = R01130.kf*IMP - R01130.kb*Xanthosine_space_5_space_minus_phosphate; R01054 = R01054.kf*ADP_minus_ribose - R01054.kb*D_minus_Ribose_space_5_minus_phosphate; R00529 = R00529.kf*Sulfate - R00529.kb*Adenylyl_space_sulfate; R00722 = R00722.kf*IDP - R00722.kb*ITP; R02019 = R02019.kf*dGDP - R02019.kb*GDP; R01863 = R01863.kf*Inosine - R01863.kb*Hypoxanthine; R04378 = R04378.kf*space_1_minus_space_5_space_minus_Phosphoribosyl_space_minus_5_minus_amino_minus_4_minus_imidazolecarboxamide - R04378.kb*space_5_minus_Amino_minus_4_minus_imidazolecarboxyamide; R02748 = R02748.kf*Deoxyinosine - R02748.kb*Hypoxanthine; R01969 = R01969.kf*Deoxyguanosine - R01969.kb*Guanine; R00375 = R00375.kf*dATP - R00375.kb*DNA; R01126 = R01126.kf*IMP - R01126.kb*Inosine; R02557 = R02557.kf*Adenine - R02557.kb*Deoxyadenosine; R01230 = R01230.kf*Xanthosine_space_5_space_minus_phosphate - R01230.kb*GMP; // variable properties default.sbmlRole="compartment"; uVol.sbmlRole="compartment"; E2_space_4_space_2_space_7.sbmlRole="species"; E2_space_4_space_2_space_7.sbmlCompartment="uVol"; E2_space_4_space_2_space_1.sbmlRole="species"; E2_space_4_space_2_space_1.sbmlCompartment="uVol"; E1_space_17_space_4_space_1.sbmlRole="species"; E1_space_17_space_4_space_1.sbmlCompartment="uVol"; E2_space_7_space_4_space_6.sbmlRole="species"; E2_space_7_space_4_space_6.sbmlCompartment="uVol"; E2_space_7_space_1_space_40.sbmlRole="species"; E2_space_7_space_1_space_40.sbmlCompartment="uVol"; E3_space_1_space_3_space_5.sbmlRole="species"; E3_space_1_space_3_space_5.sbmlCompartment="uVol"; E2_space_7_space_7_space_7.sbmlRole="species"; E2_space_7_space_7_space_7.sbmlCompartment="uVol"; E2_space_7_space_1_space_25.sbmlRole="species"; E2_space_7_space_1_space_25.sbmlCompartment="uVol"; E2_space_7_space_7_space_6.sbmlRole="species"; E2_space_7_space_7_space_6.sbmlCompartment="uVol"; E2_space_7_space_7_space_4.sbmlRole="species"; E2_space_7_space_7_space_4.sbmlCompartment="uVol"; E4_space_6_space_1_space_1.sbmlRole="species"; E4_space_6_space_1_space_1.sbmlCompartment="uVol"; E3_space_6_space_1_space_13.sbmlRole="species"; E3_space_6_space_1_space_13.sbmlCompartment="uVol"; E2_space_7_space_4_space_3.sbmlRole="species"; E2_space_7_space_4_space_3.sbmlCompartment="uVol"; E3_space_6_space_1_space_15.sbmlRole="species"; E3_space_6_space_1_space_15.sbmlCompartment="uVol"; E2_space_7_space_6_space_1.sbmlRole="species"; E2_space_7_space_6_space_1.sbmlCompartment="uVol"; E2_space_7_space_2_space_2.sbmlRole="species"; E2_space_7_space_2_space_2.sbmlCompartment="uVol"; E1_space_1_space_1_space_205.sbmlRole="species"; E1_space_1_space_1_space_205.sbmlCompartment="uVol"; E6_space_3_space_5_space_2.sbmlRole="species"; E6_space_3_space_5_space_2.sbmlCompartment="uVol"; GDP.sbmlRole="species"; GDP.sbmlCompartment="uVol"; dGDP.sbmlRole="species"; dGDP.sbmlCompartment="uVol"; dGMP.sbmlRole="species"; dGMP.sbmlCompartment="uVol"; dIDP.sbmlRole="species"; dIDP.sbmlCompartment="uVol"; GTP.sbmlRole="species"; GTP.sbmlCompartment="uVol"; dGTP.sbmlRole="species"; dGTP.sbmlCompartment="uVol"; dITP.sbmlRole="species"; dITP.sbmlCompartment="uVol"; Deoxyguanosine.sbmlRole="species"; Deoxyguanosine.sbmlCompartment="uVol"; Adenylyl_space_sulfate.sbmlRole="species"; Adenylyl_space_sulfate.sbmlCompartment="uVol"; space_3_space_minus_Phosphoadenylyl_space_sulfate.sbmlRole="species"; space_3_space_minus_Phosphoadenylyl_space_sulfate.sbmlCompartment="uVol"; RNA.sbmlRole="species"; RNA.sbmlCompartment="uVol"; Sulfate.sbmlRole="species"; Sulfate.sbmlCompartment="uVol"; DNA.sbmlRole="species"; DNA.sbmlCompartment="uVol"; space_3_space_space_5_space_minus_Cyclic_space_GMP.sbmlRole="species"; space_3_space_space_5_space_minus_Cyclic_space_GMP.sbmlCompartment="uVol"; Deoxyadenosine.sbmlRole="species"; Deoxyadenosine.sbmlCompartment="uVol"; Deoxyinosine.sbmlRole="species"; Deoxyinosine.sbmlCompartment="uVol"; ATP.sbmlRole="species"; ATP.sbmlCompartment="uVol"; dATP.sbmlRole="species"; dATP.sbmlCompartment="uVol"; ADP_minus_ribose.sbmlRole="species"; ADP_minus_ribose.sbmlCompartment="uVol"; CO2.sbmlRole="species"; CO2.sbmlCompartment="uVol"; ADP.sbmlRole="species"; ADP.sbmlCompartment="uVol"; 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