// This model generated automatically from SBML

// unit definitions
import nsrunit;
unit conversion off;

// SBML property definitions
property sbmlRole=string;
property sbmlName=string;
property sbmlCompartment=string;

// SBML reactions
// R00927: Propanoyl_minus_CoA Acetyl_minus_CoA <=> space_2_minus_Methylacetoacetyl_minus_CoA 
// R05066: space_S_space_minus_3_minus_Hydroxyisobutyrate => space_S_space_minus_Methylmalonate_space_semialdehyde 
// R00833: space_R_space_minus_2_minus_Methyl_minus_3_minus_oxopropanoyl_minus_CoA <=> Succinyl_minus_CoA 
// R04224: space_2_minus_Methylprop_minus_2_minus_enoyl_minus_CoA <=> space_S_space_minus_3_minus_Hydroxyisobutyryl_minus_CoA 
// R04095: space_3_minus_Methylbutanoyl_minus_CoA <=> space_3_minus_Methylcrotonyl_minus_CoA 
// R03172: space_S_space_minus_2_minus_Methylbutanoyl_minus_CoA <=> space_2_minus_Methylbut_minus_2_minus_enoyl_minus_CoA 
// R04137: space_3_minus_Hydroxyisovaleryl_minus_CoA => space_3_minus_Methylcrotonyl_minus_CoA 
// R07618: Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine <=> Enzyme_space_N6_minus_space_lipoyl_space_lysine 
// R04204: space_2_minus_Methylbut_minus_2_minus_enoyl_minus_CoA <=> space_2S_space_3S_space_minus_3_minus_Hydroxy_minus_2_minus_methylbutanoyl_minus_CoA 
// R00238: Acetyl_minus_CoA => Acetoacetyl_minus_CoA 
// R02661: space_2_minus_Methylpropanoyl_minus_CoA <=> space_2_minus_Methylprop_minus_2_minus_enoyl_minus_CoA 
// R04203: space_2S_space_3S_space_minus_3_minus_Hydroxy_minus_2_minus_methylbutanoyl_minus_CoA => space_2_minus_Methylacetoacetyl_minus_CoA 

math main {
  realDomain time second;
  time.min=0;
  extern time.max;
  extern time.delta;

  // variable definitions
  real default = 1 L;
  real uVol = 1 L;
  real E1_space_3_space_99_space_3 = 0 M;
  real E2_space_3_space_1_space_9 = 0 M;
  real E5_space_4_space_99_space_2 = 0 M;
  real E1_space_8_space_1_space_4 = 0 M;
  real E1_space_1_space_1_space_31 = 0 M;
  real E4_space_2_space_1_space_17 = 0 M;
  real E1_space_1_space_1_space_35 = 0 M;
  real E2_space_3_space_1_space_16 = 0 M;
  real space_3_minus_Methylbutanoyl_minus_CoA(time) M;
  real space_3_minus_Methylcrotonyl_minus_CoA(time) M;
  real Acetyl_minus_CoA(time) M;
  real Succinyl_minus_CoA(time) M;
  real Acetoacetyl_minus_CoA(time) M;
  real Enzyme_space_N6_minus_space_lipoyl_space_lysine(time) M;
  real Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine(time) M;
  real space_2_minus_Methylpropanoyl_minus_CoA(time) M;
  real space_2_minus_Methylprop_minus_2_minus_enoyl_minus_CoA(time) M;
  real space_S_space_minus_3_minus_Hydroxyisobutyryl_minus_CoA(time) M;
  real space_S_space_minus_3_minus_Hydroxyisobutyrate(time) M;
  real space_S_space_minus_Methylmalonate_space_semialdehyde(time) M;
  real space_R_space_minus_2_minus_Methyl_minus_3_minus_oxopropanoyl_minus_CoA(time) M;
  real space_S_space_minus_2_minus_Methylbutanoyl_minus_CoA(time) M;
  real space_2_minus_Methylbut_minus_2_minus_enoyl_minus_CoA(time) M;
  real space_2S_space_3S_space_minus_3_minus_Hydroxy_minus_2_minus_methylbutanoyl_minus_CoA(time) M;
  real space_2_minus_Methylacetoacetyl_minus_CoA(time) M;
  real Propanoyl_minus_CoA(time) M;
  real space_3_minus_Hydroxyisovaleryl_minus_CoA(time) M;
  real R00927(time) katal;
  extern real R00927.kf;
  extern real R00927.kb;
  real R05066(time) katal;
  extern real R05066.kf;
  extern real R05066.kb;
  real R00833(time) katal;
  extern real R00833.kf;
  extern real R00833.kb;
  real R04224(time) katal;
  extern real R04224.kf;
  extern real R04224.kb;
  real R04095(time) katal;
  extern real R04095.kf;
  extern real R04095.kb;
  real R03172(time) katal;
  extern real R03172.kf;
  extern real R03172.kb;
  real R04137(time) katal;
  extern real R04137.kf;
  extern real R04137.kb;
  real R07618(time) katal;
  extern real R07618.kf;
  extern real R07618.kb;
  real R04204(time) katal;
  extern real R04204.kf;
  extern real R04204.kb;
  real R00238(time) katal;
  extern real R00238.kf;
  extern real R00238.kb;
  real R02661(time) katal;
  extern real R02661.kf;
  extern real R02661.kb;
  real R04203(time) katal;
  extern real R04203.kf;
  extern real R04203.kb;

  // equations
  when (time=time.min) space_3_minus_Methylbutanoyl_minus_CoA = 0;
  space_3_minus_Methylbutanoyl_minus_CoA:time = (-1*R04095)/uVol;
  when (time=time.min) space_3_minus_Methylcrotonyl_minus_CoA = 0;
  space_3_minus_Methylcrotonyl_minus_CoA:time = (R04095 + R04137)/uVol;
  when (time=time.min) Acetyl_minus_CoA = 0;
  Acetyl_minus_CoA:time = (-1*R00927 + -1*R00238)/uVol;
  when (time=time.min) Succinyl_minus_CoA = 0;
  Succinyl_minus_CoA:time = (R00833)/uVol;
  when (time=time.min) Acetoacetyl_minus_CoA = 0;
  Acetoacetyl_minus_CoA:time = (R00238)/uVol;
  when (time=time.min) Enzyme_space_N6_minus_space_lipoyl_space_lysine = 0;
  Enzyme_space_N6_minus_space_lipoyl_space_lysine:time = (R07618)/uVol;
  when (time=time.min) Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine = 0;
  Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine:time = (-1*R07618)/uVol;
  when (time=time.min) space_2_minus_Methylpropanoyl_minus_CoA = 0;
  space_2_minus_Methylpropanoyl_minus_CoA:time = (-1*R02661)/uVol;
  when (time=time.min) space_2_minus_Methylprop_minus_2_minus_enoyl_minus_CoA = 0;
  space_2_minus_Methylprop_minus_2_minus_enoyl_minus_CoA:time = (-1*R04224 + R02661)/uVol;
  when (time=time.min) space_S_space_minus_3_minus_Hydroxyisobutyryl_minus_CoA = 0;
  space_S_space_minus_3_minus_Hydroxyisobutyryl_minus_CoA:time = (R04224)/uVol;
  when (time=time.min) space_S_space_minus_3_minus_Hydroxyisobutyrate = 0;
  space_S_space_minus_3_minus_Hydroxyisobutyrate:time = (-1*R05066)/uVol;
  when (time=time.min) space_S_space_minus_Methylmalonate_space_semialdehyde = 0;
  space_S_space_minus_Methylmalonate_space_semialdehyde:time = (R05066)/uVol;
  when (time=time.min) space_R_space_minus_2_minus_Methyl_minus_3_minus_oxopropanoyl_minus_CoA = 0;
  space_R_space_minus_2_minus_Methyl_minus_3_minus_oxopropanoyl_minus_CoA:time = (-1*R00833)/uVol;
  when (time=time.min) space_S_space_minus_2_minus_Methylbutanoyl_minus_CoA = 0;
  space_S_space_minus_2_minus_Methylbutanoyl_minus_CoA:time = (-1*R03172)/uVol;
  when (time=time.min) space_2_minus_Methylbut_minus_2_minus_enoyl_minus_CoA = 0;
  space_2_minus_Methylbut_minus_2_minus_enoyl_minus_CoA:time = (R03172 + -1*R04204)/uVol;
  when (time=time.min) space_2S_space_3S_space_minus_3_minus_Hydroxy_minus_2_minus_methylbutanoyl_minus_CoA = 0;
  space_2S_space_3S_space_minus_3_minus_Hydroxy_minus_2_minus_methylbutanoyl_minus_CoA:time = (R04204 + -1*R04203)/uVol;
  when (time=time.min) space_2_minus_Methylacetoacetyl_minus_CoA = 0;
  space_2_minus_Methylacetoacetyl_minus_CoA:time = (R00927 + R04203)/uVol;
  when (time=time.min) Propanoyl_minus_CoA = 0;
  Propanoyl_minus_CoA:time = (-1*R00927)/uVol;
  when (time=time.min) space_3_minus_Hydroxyisovaleryl_minus_CoA = 0;
  space_3_minus_Hydroxyisovaleryl_minus_CoA:time = (-1*R04137)/uVol;
  R00927 = R00927.kf*Propanoyl_minus_CoA*Acetyl_minus_CoA - R00927.kb*space_2_minus_Methylacetoacetyl_minus_CoA;
  R05066 = R05066.kf*space_S_space_minus_3_minus_Hydroxyisobutyrate - R05066.kb*space_S_space_minus_Methylmalonate_space_semialdehyde;
  R00833 = R00833.kf*space_R_space_minus_2_minus_Methyl_minus_3_minus_oxopropanoyl_minus_CoA - R00833.kb*Succinyl_minus_CoA;
  R04224 = R04224.kf*space_2_minus_Methylprop_minus_2_minus_enoyl_minus_CoA - R04224.kb*space_S_space_minus_3_minus_Hydroxyisobutyryl_minus_CoA;
  R04095 = R04095.kf*space_3_minus_Methylbutanoyl_minus_CoA - R04095.kb*space_3_minus_Methylcrotonyl_minus_CoA;
  R03172 = R03172.kf*space_S_space_minus_2_minus_Methylbutanoyl_minus_CoA - R03172.kb*space_2_minus_Methylbut_minus_2_minus_enoyl_minus_CoA;
  R04137 = R04137.kf*space_3_minus_Hydroxyisovaleryl_minus_CoA - R04137.kb*space_3_minus_Methylcrotonyl_minus_CoA;
  R07618 = R07618.kf*Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine - R07618.kb*Enzyme_space_N6_minus_space_lipoyl_space_lysine;
  R04204 = R04204.kf*space_2_minus_Methylbut_minus_2_minus_enoyl_minus_CoA - R04204.kb*space_2S_space_3S_space_minus_3_minus_Hydroxy_minus_2_minus_methylbutanoyl_minus_CoA;
  R00238 = R00238.kf*Acetyl_minus_CoA - R00238.kb*Acetoacetyl_minus_CoA;
  R02661 = R02661.kf*space_2_minus_Methylpropanoyl_minus_CoA - R02661.kb*space_2_minus_Methylprop_minus_2_minus_enoyl_minus_CoA;
  R04203 = R04203.kf*space_2S_space_3S_space_minus_3_minus_Hydroxy_minus_2_minus_methylbutanoyl_minus_CoA - R04203.kb*space_2_minus_Methylacetoacetyl_minus_CoA;

  // variable properties
  default.sbmlRole="compartment";
  uVol.sbmlRole="compartment";
  E1_space_3_space_99_space_3.sbmlRole="species";
  E1_space_3_space_99_space_3.sbmlCompartment="uVol";
  E2_space_3_space_1_space_9.sbmlRole="species";
  E2_space_3_space_1_space_9.sbmlCompartment="uVol";
  E5_space_4_space_99_space_2.sbmlRole="species";
  E5_space_4_space_99_space_2.sbmlCompartment="uVol";
  E1_space_8_space_1_space_4.sbmlRole="species";
  E1_space_8_space_1_space_4.sbmlCompartment="uVol";
  E1_space_1_space_1_space_31.sbmlRole="species";
  E1_space_1_space_1_space_31.sbmlCompartment="uVol";
  E4_space_2_space_1_space_17.sbmlRole="species";
  E4_space_2_space_1_space_17.sbmlCompartment="uVol";
  E1_space_1_space_1_space_35.sbmlRole="species";
  E1_space_1_space_1_space_35.sbmlCompartment="uVol";
  E2_space_3_space_1_space_16.sbmlRole="species";
  E2_space_3_space_1_space_16.sbmlCompartment="uVol";
  space_3_minus_Methylbutanoyl_minus_CoA.sbmlRole="species";
  space_3_minus_Methylbutanoyl_minus_CoA.sbmlCompartment="uVol";
  space_3_minus_Methylcrotonyl_minus_CoA.sbmlRole="species";
  space_3_minus_Methylcrotonyl_minus_CoA.sbmlCompartment="uVol";
  Acetyl_minus_CoA.sbmlRole="species";
  Acetyl_minus_CoA.sbmlCompartment="uVol";
  Succinyl_minus_CoA.sbmlRole="species";
  Succinyl_minus_CoA.sbmlCompartment="uVol";
  Acetoacetyl_minus_CoA.sbmlRole="species";
  Acetoacetyl_minus_CoA.sbmlCompartment="uVol";
  Enzyme_space_N6_minus_space_lipoyl_space_lysine.sbmlRole="species";
  Enzyme_space_N6_minus_space_lipoyl_space_lysine.sbmlCompartment="uVol";
  Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine.sbmlRole="species";
  Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine.sbmlCompartment="uVol";
  space_2_minus_Methylpropanoyl_minus_CoA.sbmlRole="species";
  space_2_minus_Methylpropanoyl_minus_CoA.sbmlCompartment="uVol";
  space_2_minus_Methylprop_minus_2_minus_enoyl_minus_CoA.sbmlRole="species";
  space_2_minus_Methylprop_minus_2_minus_enoyl_minus_CoA.sbmlCompartment="uVol";
  space_S_space_minus_3_minus_Hydroxyisobutyryl_minus_CoA.sbmlRole="species";
  space_S_space_minus_3_minus_Hydroxyisobutyryl_minus_CoA.sbmlCompartment="uVol";
  space_S_space_minus_3_minus_Hydroxyisobutyrate.sbmlRole="species";
  space_S_space_minus_3_minus_Hydroxyisobutyrate.sbmlCompartment="uVol";
  space_S_space_minus_Methylmalonate_space_semialdehyde.sbmlRole="species";
  space_S_space_minus_Methylmalonate_space_semialdehyde.sbmlCompartment="uVol";
  space_R_space_minus_2_minus_Methyl_minus_3_minus_oxopropanoyl_minus_CoA.sbmlRole="species";
  space_R_space_minus_2_minus_Methyl_minus_3_minus_oxopropanoyl_minus_CoA.sbmlCompartment="uVol";
  space_S_space_minus_2_minus_Methylbutanoyl_minus_CoA.sbmlRole="species";
  space_S_space_minus_2_minus_Methylbutanoyl_minus_CoA.sbmlCompartment="uVol";
  space_2_minus_Methylbut_minus_2_minus_enoyl_minus_CoA.sbmlRole="species";
  space_2_minus_Methylbut_minus_2_minus_enoyl_minus_CoA.sbmlCompartment="uVol";
  space_2S_space_3S_space_minus_3_minus_Hydroxy_minus_2_minus_methylbutanoyl_minus_CoA.sbmlRole="species";
  space_2S_space_3S_space_minus_3_minus_Hydroxy_minus_2_minus_methylbutanoyl_minus_CoA.sbmlCompartment="uVol";
  space_2_minus_Methylacetoacetyl_minus_CoA.sbmlRole="species";
  space_2_minus_Methylacetoacetyl_minus_CoA.sbmlCompartment="uVol";
  Propanoyl_minus_CoA.sbmlRole="species";
  Propanoyl_minus_CoA.sbmlCompartment="uVol";
  space_3_minus_Hydroxyisovaleryl_minus_CoA.sbmlRole="species";
  space_3_minus_Hydroxyisovaleryl_minus_CoA.sbmlCompartment="uVol";
  R00927.sbmlRole="rate";
  R00927.kf.sbmlRole="rate";
  R00927.kb.sbmlRole="rate";
  R05066.sbmlRole="rate";
  R05066.kf.sbmlRole="rate";
  R05066.kb.sbmlRole="rate";
  R00833.sbmlRole="rate";
  R00833.kf.sbmlRole="rate";
  R00833.kb.sbmlRole="rate";
  R04224.sbmlRole="rate";
  R04224.kf.sbmlRole="rate";
  R04224.kb.sbmlRole="rate";
  R04095.sbmlRole="rate";
  R04095.kf.sbmlRole="rate";
  R04095.kb.sbmlRole="rate";
  R03172.sbmlRole="rate";
  R03172.kf.sbmlRole="rate";
  R03172.kb.sbmlRole="rate";
  R04137.sbmlRole="rate";
  R04137.kf.sbmlRole="rate";
  R04137.kb.sbmlRole="rate";
  R07618.sbmlRole="rate";
  R07618.kf.sbmlRole="rate";
  R07618.kb.sbmlRole="rate";
  R04204.sbmlRole="rate";
  R04204.kf.sbmlRole="rate";
  R04204.kb.sbmlRole="rate";
  R00238.sbmlRole="rate";
  R00238.kf.sbmlRole="rate";
  R00238.kb.sbmlRole="rate";
  R02661.sbmlRole="rate";
  R02661.kf.sbmlRole="rate";
  R02661.kb.sbmlRole="rate";
  R04203.sbmlRole="rate";
  R04203.kf.sbmlRole="rate";
  R04203.kb.sbmlRole="rate";
}