// This model generated automatically from SBML

// unit definitions
import nsrunit;
unit conversion off;

// SBML property definitions
property sbmlRole=string;
property sbmlName=string;
property sbmlCompartment=string;

// SBML reactions
// R00405: Succinate => Succinyl_minus_CoA 
// R00351: Citrate CoA <=> Acetyl_minus_CoA Oxaloacetate 
// R01324: Citrate => Isocitrate 
// R00268: Oxalosuccinate => space_2_minus_Oxoglutarate CO2 
// R01325: Citrate => cis_minus_Aconitate 
// R00342: space_S_space_minus_Malate => Oxaloacetate 
// R00431: Oxaloacetate => Phosphoenolpyruvate 
// R01900: cis_minus_Aconitate => Isocitrate 
// R03316: space_3_minus_Carboxy_minus_1_minus_hydroxypropyl_minus_ThPP Enzyme_space_N6_minus_space_lipoyl_space_lysine <=> space_Dihydrolipoyllysine_minus_residue_space_succinyltransferase_space_ Thiamin_space_diphosphate 
// R00412: Succinate => Fumarate 
// R00362: Citrate => Acetate Oxaloacetate 
// R01082: space_S_space_minus_Malate => Fumarate 
// R02570: Succinyl_minus_CoA Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine => space_Dihydrolipoyllysine_minus_residue_space_succinyltransferase_space_ 
// R01899: Isocitrate => Oxalosuccinate 
// R07618: Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine => Enzyme_space_N6_minus_space_lipoyl_space_lysine 
// R00621: space_2_minus_Oxoglutarate Thiamin_space_diphosphate <=> space_3_minus_Carboxy_minus_1_minus_hydroxypropyl_minus_ThPP CO2 

math main {
  realDomain time second;
  time.min=0;
  extern time.max;
  extern time.delta;

  // variable definitions
  real default = 1 L;
  real uVol = 1 L;
  real E1_space_3_space_99_space_1 = 0 M;
  real E4_space_2_space_1_space_2 = 0 M;
  real E1_space_1_space_1_space_37 = 0 M;
  real E6_space_2_space_1_space_5 = 0 M;
  real E4_space_1_space_1_space_32 = 0 M;
  real E2_space_3_space_1_space_61 = 0 M;
  real E2_space_3_space_3_space_1 = 0 M;
  real E1_space_8_space_1_space_4 = 0 M;
  real E4_space_1_space_3_space_6 = 0 M;
  real E1_space_2_space_4_space_2 = 0 M;
  real E4_space_2_space_1_space_3 = 0 M;
  real E1_space_1_space_1_space_42 = 0 M;
  real Succinate(time) M;
  real space_S_space_minus_Malate(time) M;
  real Fumarate(time) M;
  real Oxaloacetate(time) M;
  real Succinyl_minus_CoA(time) M;
  real Acetyl_minus_CoA(time) M;
  real Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine(time) M;
  real Phosphoenolpyruvate(time) M;
  real space_Dihydrolipoyllysine_minus_residue_space_succinyltransferase_space_(time) M;
  real CoA(time) M;
  real Citrate(time) M;
  real Enzyme_space_N6_minus_space_lipoyl_space_lysine(time) M;
  real Acetate(time) M;
  real Thiamin_space_diphosphate(time) M;
  real space_3_minus_Carboxy_minus_1_minus_hydroxypropyl_minus_ThPP(time) M;
  real CO2(time) M;
  real cis_minus_Aconitate(time) M;
  real Isocitrate(time) M;
  real Oxalosuccinate(time) M;
  real space_2_minus_Oxoglutarate(time) M;
  real R00405(time) katal;
  extern real R00405.kf;
  extern real R00405.kb;
  real R00351(time) katal;
  extern real R00351.kf;
  extern real R00351.kb;
  real R01324(time) katal;
  extern real R01324.kf;
  extern real R01324.kb;
  real R00268(time) katal;
  extern real R00268.kf;
  extern real R00268.kb;
  real R01325(time) katal;
  extern real R01325.kf;
  extern real R01325.kb;
  real R00342(time) katal;
  extern real R00342.kf;
  extern real R00342.kb;
  real R00431(time) katal;
  extern real R00431.kf;
  extern real R00431.kb;
  real R01900(time) katal;
  extern real R01900.kf;
  extern real R01900.kb;
  real R03316(time) katal;
  extern real R03316.kf;
  extern real R03316.kb;
  real R00412(time) katal;
  extern real R00412.kf;
  extern real R00412.kb;
  real R00362(time) katal;
  extern real R00362.kf;
  extern real R00362.kb;
  real R01082(time) katal;
  extern real R01082.kf;
  extern real R01082.kb;
  real R02570(time) katal;
  extern real R02570.kf;
  extern real R02570.kb;
  real R01899(time) katal;
  extern real R01899.kf;
  extern real R01899.kb;
  real R07618(time) katal;
  extern real R07618.kf;
  extern real R07618.kb;
  real R00621(time) katal;
  extern real R00621.kf;
  extern real R00621.kb;

  // equations
  when (time=time.min) Succinate = 0;
  Succinate:time = (-1*R00405 + -1*R00412)/uVol;
  when (time=time.min) space_S_space_minus_Malate = 0;
  space_S_space_minus_Malate:time = (-1*R00342 + -1*R01082)/uVol;
  when (time=time.min) Fumarate = 0;
  Fumarate:time = (R00412 + R01082)/uVol;
  when (time=time.min) Oxaloacetate = 0;
  Oxaloacetate:time = (R00351 + R00342 + -1*R00431 + R00362)/uVol;
  when (time=time.min) Succinyl_minus_CoA = 0;
  Succinyl_minus_CoA:time = (R00405 + -1*R02570)/uVol;
  when (time=time.min) Acetyl_minus_CoA = 0;
  Acetyl_minus_CoA:time = (R00351)/uVol;
  when (time=time.min) Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine = 0;
  Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine:time = (-1*R02570 + -1*R07618)/uVol;
  when (time=time.min) Phosphoenolpyruvate = 0;
  Phosphoenolpyruvate:time = (R00431)/uVol;
  when (time=time.min) space_Dihydrolipoyllysine_minus_residue_space_succinyltransferase_space_ = 0;
  space_Dihydrolipoyllysine_minus_residue_space_succinyltransferase_space_:time = (R03316 + R02570)/uVol;
  when (time=time.min) CoA = 0;
  CoA:time = (-1*R00351)/uVol;
  when (time=time.min) Citrate = 0;
  Citrate:time = (-1*R00351 + -1*R01324 + -1*R01325 + -1*R00362)/uVol;
  when (time=time.min) Enzyme_space_N6_minus_space_lipoyl_space_lysine = 0;
  Enzyme_space_N6_minus_space_lipoyl_space_lysine:time = (-1*R03316 + R07618)/uVol;
  when (time=time.min) Acetate = 0;
  Acetate:time = (R00362)/uVol;
  when (time=time.min) Thiamin_space_diphosphate = 0;
  Thiamin_space_diphosphate:time = (R03316 + -1*R00621)/uVol;
  when (time=time.min) space_3_minus_Carboxy_minus_1_minus_hydroxypropyl_minus_ThPP = 0;
  space_3_minus_Carboxy_minus_1_minus_hydroxypropyl_minus_ThPP:time = (-1*R03316 + R00621)/uVol;
  when (time=time.min) CO2 = 0;
  CO2:time = (R00268 + R00621)/uVol;
  when (time=time.min) cis_minus_Aconitate = 0;
  cis_minus_Aconitate:time = (R01325 + -1*R01900)/uVol;
  when (time=time.min) Isocitrate = 0;
  Isocitrate:time = (R01324 + R01900 + -1*R01899)/uVol;
  when (time=time.min) Oxalosuccinate = 0;
  Oxalosuccinate:time = (-1*R00268 + R01899)/uVol;
  when (time=time.min) space_2_minus_Oxoglutarate = 0;
  space_2_minus_Oxoglutarate:time = (R00268 + -1*R00621)/uVol;
  R00405 = R00405.kf*Succinate - R00405.kb*Succinyl_minus_CoA;
  R00351 = R00351.kf*Citrate*CoA - R00351.kb*Acetyl_minus_CoA*Oxaloacetate;
  R01324 = R01324.kf*Citrate - R01324.kb*Isocitrate;
  R00268 = R00268.kf*Oxalosuccinate - R00268.kb*space_2_minus_Oxoglutarate*CO2;
  R01325 = R01325.kf*Citrate - R01325.kb*cis_minus_Aconitate;
  R00342 = R00342.kf*space_S_space_minus_Malate - R00342.kb*Oxaloacetate;
  R00431 = R00431.kf*Oxaloacetate - R00431.kb*Phosphoenolpyruvate;
  R01900 = R01900.kf*cis_minus_Aconitate - R01900.kb*Isocitrate;
  R03316 = R03316.kf*space_3_minus_Carboxy_minus_1_minus_hydroxypropyl_minus_ThPP*Enzyme_space_N6_minus_space_lipoyl_space_lysine - R03316.kb*space_Dihydrolipoyllysine_minus_residue_space_succinyltransferase_space_*Thiamin_space_diphosphate;
  R00412 = R00412.kf*Succinate - R00412.kb*Fumarate;
  R00362 = R00362.kf*Citrate - R00362.kb*Acetate*Oxaloacetate;
  R01082 = R01082.kf*space_S_space_minus_Malate - R01082.kb*Fumarate;
  R02570 = R02570.kf*Succinyl_minus_CoA*Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine - R02570.kb*space_Dihydrolipoyllysine_minus_residue_space_succinyltransferase_space_;
  R01899 = R01899.kf*Isocitrate - R01899.kb*Oxalosuccinate;
  R07618 = R07618.kf*Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine - R07618.kb*Enzyme_space_N6_minus_space_lipoyl_space_lysine;
  R00621 = R00621.kf*space_2_minus_Oxoglutarate*Thiamin_space_diphosphate - R00621.kb*space_3_minus_Carboxy_minus_1_minus_hydroxypropyl_minus_ThPP*CO2;

  // variable properties
  default.sbmlRole="compartment";
  uVol.sbmlRole="compartment";
  E1_space_3_space_99_space_1.sbmlRole="species";
  E1_space_3_space_99_space_1.sbmlCompartment="uVol";
  E4_space_2_space_1_space_2.sbmlRole="species";
  E4_space_2_space_1_space_2.sbmlCompartment="uVol";
  E1_space_1_space_1_space_37.sbmlRole="species";
  E1_space_1_space_1_space_37.sbmlCompartment="uVol";
  E6_space_2_space_1_space_5.sbmlRole="species";
  E6_space_2_space_1_space_5.sbmlCompartment="uVol";
  E4_space_1_space_1_space_32.sbmlRole="species";
  E4_space_1_space_1_space_32.sbmlCompartment="uVol";
  E2_space_3_space_1_space_61.sbmlRole="species";
  E2_space_3_space_1_space_61.sbmlCompartment="uVol";
  E2_space_3_space_3_space_1.sbmlRole="species";
  E2_space_3_space_3_space_1.sbmlCompartment="uVol";
  E1_space_8_space_1_space_4.sbmlRole="species";
  E1_space_8_space_1_space_4.sbmlCompartment="uVol";
  E4_space_1_space_3_space_6.sbmlRole="species";
  E4_space_1_space_3_space_6.sbmlCompartment="uVol";
  E1_space_2_space_4_space_2.sbmlRole="species";
  E1_space_2_space_4_space_2.sbmlCompartment="uVol";
  E4_space_2_space_1_space_3.sbmlRole="species";
  E4_space_2_space_1_space_3.sbmlCompartment="uVol";
  E1_space_1_space_1_space_42.sbmlRole="species";
  E1_space_1_space_1_space_42.sbmlCompartment="uVol";
  Succinate.sbmlRole="species";
  Succinate.sbmlCompartment="uVol";
  space_S_space_minus_Malate.sbmlRole="species";
  space_S_space_minus_Malate.sbmlCompartment="uVol";
  Fumarate.sbmlRole="species";
  Fumarate.sbmlCompartment="uVol";
  Oxaloacetate.sbmlRole="species";
  Oxaloacetate.sbmlCompartment="uVol";
  Succinyl_minus_CoA.sbmlRole="species";
  Succinyl_minus_CoA.sbmlCompartment="uVol";
  Acetyl_minus_CoA.sbmlRole="species";
  Acetyl_minus_CoA.sbmlCompartment="uVol";
  Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine.sbmlRole="species";
  Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine.sbmlCompartment="uVol";
  Phosphoenolpyruvate.sbmlRole="species";
  Phosphoenolpyruvate.sbmlCompartment="uVol";
  space_Dihydrolipoyllysine_minus_residue_space_succinyltransferase_space_.sbmlRole="species";
  space_Dihydrolipoyllysine_minus_residue_space_succinyltransferase_space_.sbmlCompartment="uVol";
  CoA.sbmlRole="species";
  CoA.sbmlCompartment="uVol";
  Citrate.sbmlRole="species";
  Citrate.sbmlCompartment="uVol";
  Enzyme_space_N6_minus_space_lipoyl_space_lysine.sbmlRole="species";
  Enzyme_space_N6_minus_space_lipoyl_space_lysine.sbmlCompartment="uVol";
  Acetate.sbmlRole="species";
  Acetate.sbmlCompartment="uVol";
  Thiamin_space_diphosphate.sbmlRole="species";
  Thiamin_space_diphosphate.sbmlCompartment="uVol";
  space_3_minus_Carboxy_minus_1_minus_hydroxypropyl_minus_ThPP.sbmlRole="species";
  space_3_minus_Carboxy_minus_1_minus_hydroxypropyl_minus_ThPP.sbmlCompartment="uVol";
  CO2.sbmlRole="species";
  CO2.sbmlCompartment="uVol";
  cis_minus_Aconitate.sbmlRole="species";
  cis_minus_Aconitate.sbmlCompartment="uVol";
  Isocitrate.sbmlRole="species";
  Isocitrate.sbmlCompartment="uVol";
  Oxalosuccinate.sbmlRole="species";
  Oxalosuccinate.sbmlCompartment="uVol";
  space_2_minus_Oxoglutarate.sbmlRole="species";
  space_2_minus_Oxoglutarate.sbmlCompartment="uVol";
  R00405.sbmlRole="rate";
  R00405.kf.sbmlRole="rate";
  R00405.kb.sbmlRole="rate";
  R00351.sbmlRole="rate";
  R00351.kf.sbmlRole="rate";
  R00351.kb.sbmlRole="rate";
  R01324.sbmlRole="rate";
  R01324.kf.sbmlRole="rate";
  R01324.kb.sbmlRole="rate";
  R00268.sbmlRole="rate";
  R00268.kf.sbmlRole="rate";
  R00268.kb.sbmlRole="rate";
  R01325.sbmlRole="rate";
  R01325.kf.sbmlRole="rate";
  R01325.kb.sbmlRole="rate";
  R00342.sbmlRole="rate";
  R00342.kf.sbmlRole="rate";
  R00342.kb.sbmlRole="rate";
  R00431.sbmlRole="rate";
  R00431.kf.sbmlRole="rate";
  R00431.kb.sbmlRole="rate";
  R01900.sbmlRole="rate";
  R01900.kf.sbmlRole="rate";
  R01900.kb.sbmlRole="rate";
  R03316.sbmlRole="rate";
  R03316.kf.sbmlRole="rate";
  R03316.kb.sbmlRole="rate";
  R00412.sbmlRole="rate";
  R00412.kf.sbmlRole="rate";
  R00412.kb.sbmlRole="rate";
  R00362.sbmlRole="rate";
  R00362.kf.sbmlRole="rate";
  R00362.kb.sbmlRole="rate";
  R01082.sbmlRole="rate";
  R01082.kf.sbmlRole="rate";
  R01082.kb.sbmlRole="rate";
  R02570.sbmlRole="rate";
  R02570.kf.sbmlRole="rate";
  R02570.kb.sbmlRole="rate";
  R01899.sbmlRole="rate";
  R01899.kf.sbmlRole="rate";
  R01899.kb.sbmlRole="rate";
  R07618.sbmlRole="rate";
  R07618.kf.sbmlRole="rate";
  R07618.kb.sbmlRole="rate";
  R00621.sbmlRole="rate";
  R00621.kf.sbmlRole="rate";
  R00621.kb.sbmlRole="rate";
}