// This model generated automatically from SBML

// unit definitions
import nsrunit;
unit conversion off;

// SBML property definitions
property sbmlRole=string;
property sbmlName=string;
property sbmlCompartment=string;

// SBML reactions
// R02356: Estrone <=> space_16_alpha_minus_Hydroxyestrone 
// R03088: Estradiol_minus_17beta <=> space_2_minus_Hydroxyestradiol_minus_17beta 
// R03089: Estradiol_minus_17beta <=> Estriol 
// R01836: Testosterone => Androst_minus_4_minus_ene_minus_3_space_17_minus_dione 
// R02354: Estrone <=> space_2_minus_Hydroxyestrone 
// R02352: Estradiol_minus_17beta => Estrone 
// R03406: space_3_beta_minus_Hydroxyandrost_minus_5_minus_en_minus_17_minus_one <=> Androst_minus_5_minus_ene_minus_3_beta_space_17_beta_minus_diol 

math main {
  realDomain time second;
  time.min=0;
  extern time.max;
  extern time.delta;

  // variable definitions
  real default = 1 L;
  real uVol = 1 L;
  real E1_space_14_space_13_space_minus_ = 0 M;
  real E1_space_1_space_1_space_51 = 0 M;
  real space_2_minus_Hydroxyestrone(time) M;
  real space_3_beta_minus_Hydroxyandrost_minus_5_minus_en_minus_17_minus_one(time) M;
  real Androst_minus_4_minus_ene_minus_3_space_17_minus_dione(time) M;
  real Estrone(time) M;
  real space_16_alpha_minus_Hydroxyestrone(time) M;
  real Androst_minus_5_minus_ene_minus_3_beta_space_17_beta_minus_diol(time) M;
  real Testosterone(time) M;
  real Estradiol_minus_17beta(time) M;
  real Estriol(time) M;
  real space_2_minus_Hydroxyestradiol_minus_17beta(time) M;
  real R02356(time) katal;
  extern real R02356.kf;
  extern real R02356.kb;
  real R03088(time) katal;
  extern real R03088.kf;
  extern real R03088.kb;
  real R03089(time) katal;
  extern real R03089.kf;
  extern real R03089.kb;
  real R01836(time) katal;
  extern real R01836.kf;
  extern real R01836.kb;
  real R02354(time) katal;
  extern real R02354.kf;
  extern real R02354.kb;
  real R02352(time) katal;
  extern real R02352.kf;
  extern real R02352.kb;
  real R03406(time) katal;
  extern real R03406.kf;
  extern real R03406.kb;

  // equations
  when (time=time.min) space_2_minus_Hydroxyestrone = 0;
  space_2_minus_Hydroxyestrone:time = (R02354)/uVol;
  when (time=time.min) space_3_beta_minus_Hydroxyandrost_minus_5_minus_en_minus_17_minus_one = 0;
  space_3_beta_minus_Hydroxyandrost_minus_5_minus_en_minus_17_minus_one:time = (-1*R03406)/uVol;
  when (time=time.min) Androst_minus_4_minus_ene_minus_3_space_17_minus_dione = 0;
  Androst_minus_4_minus_ene_minus_3_space_17_minus_dione:time = (R01836)/uVol;
  when (time=time.min) Estrone = 0;
  Estrone:time = (-1*R02356 + -1*R02354 + R02352)/uVol;
  when (time=time.min) space_16_alpha_minus_Hydroxyestrone = 0;
  space_16_alpha_minus_Hydroxyestrone:time = (R02356)/uVol;
  when (time=time.min) Androst_minus_5_minus_ene_minus_3_beta_space_17_beta_minus_diol = 0;
  Androst_minus_5_minus_ene_minus_3_beta_space_17_beta_minus_diol:time = (R03406)/uVol;
  when (time=time.min) Testosterone = 0;
  Testosterone:time = (-1*R01836)/uVol;
  when (time=time.min) Estradiol_minus_17beta = 0;
  Estradiol_minus_17beta:time = (-1*R03088 + -1*R03089 + -1*R02352)/uVol;
  when (time=time.min) Estriol = 0;
  Estriol:time = (R03089)/uVol;
  when (time=time.min) space_2_minus_Hydroxyestradiol_minus_17beta = 0;
  space_2_minus_Hydroxyestradiol_minus_17beta:time = (R03088)/uVol;
  R02356 = R02356.kf*Estrone - R02356.kb*space_16_alpha_minus_Hydroxyestrone;
  R03088 = R03088.kf*Estradiol_minus_17beta - R03088.kb*space_2_minus_Hydroxyestradiol_minus_17beta;
  R03089 = R03089.kf*Estradiol_minus_17beta - R03089.kb*Estriol;
  R01836 = R01836.kf*Testosterone - R01836.kb*Androst_minus_4_minus_ene_minus_3_space_17_minus_dione;
  R02354 = R02354.kf*Estrone - R02354.kb*space_2_minus_Hydroxyestrone;
  R02352 = R02352.kf*Estradiol_minus_17beta - R02352.kb*Estrone;
  R03406 = R03406.kf*space_3_beta_minus_Hydroxyandrost_minus_5_minus_en_minus_17_minus_one - R03406.kb*Androst_minus_5_minus_ene_minus_3_beta_space_17_beta_minus_diol;

  // variable properties
  default.sbmlRole="compartment";
  uVol.sbmlRole="compartment";
  E1_space_14_space_13_space_minus_.sbmlRole="species";
  E1_space_14_space_13_space_minus_.sbmlCompartment="uVol";
  E1_space_1_space_1_space_51.sbmlRole="species";
  E1_space_1_space_1_space_51.sbmlCompartment="uVol";
  space_2_minus_Hydroxyestrone.sbmlRole="species";
  space_2_minus_Hydroxyestrone.sbmlCompartment="uVol";
  space_3_beta_minus_Hydroxyandrost_minus_5_minus_en_minus_17_minus_one.sbmlRole="species";
  space_3_beta_minus_Hydroxyandrost_minus_5_minus_en_minus_17_minus_one.sbmlCompartment="uVol";
  Androst_minus_4_minus_ene_minus_3_space_17_minus_dione.sbmlRole="species";
  Androst_minus_4_minus_ene_minus_3_space_17_minus_dione.sbmlCompartment="uVol";
  Estrone.sbmlRole="species";
  Estrone.sbmlCompartment="uVol";
  space_16_alpha_minus_Hydroxyestrone.sbmlRole="species";
  space_16_alpha_minus_Hydroxyestrone.sbmlCompartment="uVol";
  Androst_minus_5_minus_ene_minus_3_beta_space_17_beta_minus_diol.sbmlRole="species";
  Androst_minus_5_minus_ene_minus_3_beta_space_17_beta_minus_diol.sbmlCompartment="uVol";
  Testosterone.sbmlRole="species";
  Testosterone.sbmlCompartment="uVol";
  Estradiol_minus_17beta.sbmlRole="species";
  Estradiol_minus_17beta.sbmlCompartment="uVol";
  Estriol.sbmlRole="species";
  Estriol.sbmlCompartment="uVol";
  space_2_minus_Hydroxyestradiol_minus_17beta.sbmlRole="species";
  space_2_minus_Hydroxyestradiol_minus_17beta.sbmlCompartment="uVol";
  R02356.sbmlRole="rate";
  R02356.kf.sbmlRole="rate";
  R02356.kb.sbmlRole="rate";
  R03088.sbmlRole="rate";
  R03088.kf.sbmlRole="rate";
  R03088.kb.sbmlRole="rate";
  R03089.sbmlRole="rate";
  R03089.kf.sbmlRole="rate";
  R03089.kb.sbmlRole="rate";
  R01836.sbmlRole="rate";
  R01836.kf.sbmlRole="rate";
  R01836.kb.sbmlRole="rate";
  R02354.sbmlRole="rate";
  R02354.kf.sbmlRole="rate";
  R02354.kb.sbmlRole="rate";
  R02352.sbmlRole="rate";
  R02352.kf.sbmlRole="rate";
  R02352.kb.sbmlRole="rate";
  R03406.sbmlRole="rate";
  R03406.kf.sbmlRole="rate";
  R03406.kb.sbmlRole="rate";
}