// This model generated automatically from SBML

// unit definitions
import nsrunit;
unit conversion off;

// SBML property definitions
property sbmlRole=string;
property sbmlName=string;
property sbmlCompartment=string;

// SBML reactions
// R00405: Succinate => Succinyl_minus_CoA 
// R01325: Citrate => cis_minus_Aconitate 
// R01899: Isocitrate => Oxalosuccinate 
// R01900: cis_minus_Aconitate => Isocitrate 
// R00351: Citrate CoA <=> Acetyl_minus_CoA Oxaloacetate 
// R00412: Succinate => Fumarate 
// R01324: Citrate => Isocitrate 
// R07618: Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine => Enzyme_space_N6_minus_space_lipoyl_space_lysine 
// R00268: Oxalosuccinate => space_2_minus_Oxoglutarate CO2 

math main {
  realDomain time second;
  time.min=0;
  extern time.max;
  extern time.delta;

  // variable definitions
  real default = 1 L;
  real uVol = 1 L;
  real E1_space_3_space_99_space_1 = 0 M;
  real E6_space_2_space_1_space_5 = 0 M;
  real E2_space_3_space_3_space_1 = 0 M;
  real E1_space_8_space_1_space_4 = 0 M;
  real E4_space_2_space_1_space_3 = 0 M;
  real E1_space_1_space_1_space_42 = 0 M;
  real Succinate(time) M;
  real Fumarate(time) M;
  real Oxaloacetate(time) M;
  real Succinyl_minus_CoA(time) M;
  real Acetyl_minus_CoA(time) M;
  real Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine(time) M;
  real CoA(time) M;
  real Citrate(time) M;
  real Enzyme_space_N6_minus_space_lipoyl_space_lysine(time) M;
  real cis_minus_Aconitate(time) M;
  real Isocitrate(time) M;
  real Oxalosuccinate(time) M;
  real space_2_minus_Oxoglutarate(time) M;
  real CO2(time) M;
  real R00405(time) katal;
  extern real R00405.kf;
  extern real R00405.kb;
  real R01325(time) katal;
  extern real R01325.kf;
  extern real R01325.kb;
  real R01899(time) katal;
  extern real R01899.kf;
  extern real R01899.kb;
  real R01900(time) katal;
  extern real R01900.kf;
  extern real R01900.kb;
  real R00351(time) katal;
  extern real R00351.kf;
  extern real R00351.kb;
  real R00412(time) katal;
  extern real R00412.kf;
  extern real R00412.kb;
  real R01324(time) katal;
  extern real R01324.kf;
  extern real R01324.kb;
  real R07618(time) katal;
  extern real R07618.kf;
  extern real R07618.kb;
  real R00268(time) katal;
  extern real R00268.kf;
  extern real R00268.kb;

  // equations
  when (time=time.min) Succinate = 0;
  Succinate:time = (-1*R00405 + -1*R00412)/uVol;
  when (time=time.min) Fumarate = 0;
  Fumarate:time = (R00412)/uVol;
  when (time=time.min) Oxaloacetate = 0;
  Oxaloacetate:time = (R00351)/uVol;
  when (time=time.min) Succinyl_minus_CoA = 0;
  Succinyl_minus_CoA:time = (R00405)/uVol;
  when (time=time.min) Acetyl_minus_CoA = 0;
  Acetyl_minus_CoA:time = (R00351)/uVol;
  when (time=time.min) Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine = 0;
  Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine:time = (-1*R07618)/uVol;
  when (time=time.min) CoA = 0;
  CoA:time = (-1*R00351)/uVol;
  when (time=time.min) Citrate = 0;
  Citrate:time = (-1*R01325 + -1*R00351 + -1*R01324)/uVol;
  when (time=time.min) Enzyme_space_N6_minus_space_lipoyl_space_lysine = 0;
  Enzyme_space_N6_minus_space_lipoyl_space_lysine:time = (R07618)/uVol;
  when (time=time.min) cis_minus_Aconitate = 0;
  cis_minus_Aconitate:time = (R01325 + -1*R01900)/uVol;
  when (time=time.min) Isocitrate = 0;
  Isocitrate:time = (-1*R01899 + R01900 + R01324)/uVol;
  when (time=time.min) Oxalosuccinate = 0;
  Oxalosuccinate:time = (R01899 + -1*R00268)/uVol;
  when (time=time.min) space_2_minus_Oxoglutarate = 0;
  space_2_minus_Oxoglutarate:time = (R00268)/uVol;
  when (time=time.min) CO2 = 0;
  CO2:time = (R00268)/uVol;
  R00405 = R00405.kf*Succinate - R00405.kb*Succinyl_minus_CoA;
  R01325 = R01325.kf*Citrate - R01325.kb*cis_minus_Aconitate;
  R01899 = R01899.kf*Isocitrate - R01899.kb*Oxalosuccinate;
  R01900 = R01900.kf*cis_minus_Aconitate - R01900.kb*Isocitrate;
  R00351 = R00351.kf*Citrate*CoA - R00351.kb*Acetyl_minus_CoA*Oxaloacetate;
  R00412 = R00412.kf*Succinate - R00412.kb*Fumarate;
  R01324 = R01324.kf*Citrate - R01324.kb*Isocitrate;
  R07618 = R07618.kf*Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine - R07618.kb*Enzyme_space_N6_minus_space_lipoyl_space_lysine;
  R00268 = R00268.kf*Oxalosuccinate - R00268.kb*space_2_minus_Oxoglutarate*CO2;

  // variable properties
  default.sbmlRole="compartment";
  uVol.sbmlRole="compartment";
  E1_space_3_space_99_space_1.sbmlRole="species";
  E1_space_3_space_99_space_1.sbmlCompartment="uVol";
  E6_space_2_space_1_space_5.sbmlRole="species";
  E6_space_2_space_1_space_5.sbmlCompartment="uVol";
  E2_space_3_space_3_space_1.sbmlRole="species";
  E2_space_3_space_3_space_1.sbmlCompartment="uVol";
  E1_space_8_space_1_space_4.sbmlRole="species";
  E1_space_8_space_1_space_4.sbmlCompartment="uVol";
  E4_space_2_space_1_space_3.sbmlRole="species";
  E4_space_2_space_1_space_3.sbmlCompartment="uVol";
  E1_space_1_space_1_space_42.sbmlRole="species";
  E1_space_1_space_1_space_42.sbmlCompartment="uVol";
  Succinate.sbmlRole="species";
  Succinate.sbmlCompartment="uVol";
  Fumarate.sbmlRole="species";
  Fumarate.sbmlCompartment="uVol";
  Oxaloacetate.sbmlRole="species";
  Oxaloacetate.sbmlCompartment="uVol";
  Succinyl_minus_CoA.sbmlRole="species";
  Succinyl_minus_CoA.sbmlCompartment="uVol";
  Acetyl_minus_CoA.sbmlRole="species";
  Acetyl_minus_CoA.sbmlCompartment="uVol";
  Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine.sbmlRole="species";
  Enzyme_space_N6_minus_space_dihydrolipoyl_space_lysine.sbmlCompartment="uVol";
  CoA.sbmlRole="species";
  CoA.sbmlCompartment="uVol";
  Citrate.sbmlRole="species";
  Citrate.sbmlCompartment="uVol";
  Enzyme_space_N6_minus_space_lipoyl_space_lysine.sbmlRole="species";
  Enzyme_space_N6_minus_space_lipoyl_space_lysine.sbmlCompartment="uVol";
  cis_minus_Aconitate.sbmlRole="species";
  cis_minus_Aconitate.sbmlCompartment="uVol";
  Isocitrate.sbmlRole="species";
  Isocitrate.sbmlCompartment="uVol";
  Oxalosuccinate.sbmlRole="species";
  Oxalosuccinate.sbmlCompartment="uVol";
  space_2_minus_Oxoglutarate.sbmlRole="species";
  space_2_minus_Oxoglutarate.sbmlCompartment="uVol";
  CO2.sbmlRole="species";
  CO2.sbmlCompartment="uVol";
  R00405.sbmlRole="rate";
  R00405.kf.sbmlRole="rate";
  R00405.kb.sbmlRole="rate";
  R01325.sbmlRole="rate";
  R01325.kf.sbmlRole="rate";
  R01325.kb.sbmlRole="rate";
  R01899.sbmlRole="rate";
  R01899.kf.sbmlRole="rate";
  R01899.kb.sbmlRole="rate";
  R01900.sbmlRole="rate";
  R01900.kf.sbmlRole="rate";
  R01900.kb.sbmlRole="rate";
  R00351.sbmlRole="rate";
  R00351.kf.sbmlRole="rate";
  R00351.kb.sbmlRole="rate";
  R00412.sbmlRole="rate";
  R00412.kf.sbmlRole="rate";
  R00412.kb.sbmlRole="rate";
  R01324.sbmlRole="rate";
  R01324.kf.sbmlRole="rate";
  R01324.kb.sbmlRole="rate";
  R07618.sbmlRole="rate";
  R07618.kf.sbmlRole="rate";
  R07618.kb.sbmlRole="rate";
  R00268.sbmlRole="rate";
  R00268.kf.sbmlRole="rate";
  R00268.kb.sbmlRole="rate";
}