// This model generated automatically from SBML
// WARNING: Renamed variable _space_3_minus_Butyn_minus_1_minus_al to xxx_space_3_minus_Butyn_minus_1_minus_al due to JSim namespace restrictions
// WARNING: Renamed variable _space_3_minus_Butynoate to xxx_space_3_minus_Butynoate due to JSim namespace restrictions
// WARNING: Renamed variable _space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA to xxx_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA due to JSim namespace restrictions
// WARNING: Renamed variable _space_2_minus_Acetolactate to xxx_space_2_minus_Acetolactate due to JSim namespace restrictions
// WARNING: Renamed variable _space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA to xxx_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA due to JSim namespace restrictions
// WARNING: Renamed variable _space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate to xxx_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate due to JSim namespace restrictions

// unit definitions
import nsrunit;
unit conversion off;

// SBML property definitions
property sbmlRole=string;
property sbmlName=string;
property sbmlCompartment=string;

// SBML reactions
// R01976: _space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA => Acetoacetyl_minus_CoA 
// R05119: _space_3_minus_Butyn_minus_1_minus_al <=> _space_3_minus_Butynoate 
// R01975: _space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA => Acetoacetyl_minus_CoA 
// R03050: _space_2_minus_Acetolactate Thiamin_space_diphosphate <=> _space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate 
// R03026: Crotonoyl_minus_CoA => _space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA 
// R00410: Acetoacetate => Acetoacetyl_minus_CoA 
// R01171: Butanoyl_minus_CoA => Crotonoyl_minus_CoA 
// R00014: Pyruvate Thiamin_space_diphosphate <=> _space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate 
// R00408: Succinate => Fumarate 
// R00238: Acetyl_minus_CoA => Acetoacetyl_minus_CoA 
// R01360: _space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA <=> Acetyl_minus_CoA Acetoacetate 

math main {
  realDomain time second;
  time.min=0;
  extern time.max;
  extern time.delta;

  // variable definitions
  real default = 1 L;
  real uVol = 1 L;
  real E1_space_2_space_1_space_3 = 0 M;
  real E1_space_3_space_99_space_1 = 0 M;
  real E2_space_8_space_3_space_5 = 0 M;
  real E1_space_3_space_99_space_2 = 0 M;
  real E1_space_1_space_1_space_35 = 0 M;
  real E4_space_2_space_1_space_17 = 0 M;
  real E1_space_1_space_1_space_157 = 0 M;
  real E2_space_2_space_1_space_6 = 0 M;
  real E2_space_3_space_1_space_9 = 0 M;
  real E4_space_1_space_3_space_4 = 0 M;
  real E1_space_2_space_4_space_1 = 0 M;
  real xxx_space_3_minus_Butyn_minus_1_minus_al(time) M;
  real xxx_space_3_minus_Butynoate(time) M;
  real Succinate(time) M;
  real Acetoacetate(time) M;
  real Fumarate(time) M;
  real Butanoyl_minus_CoA(time) M;
  real Crotonoyl_minus_CoA(time) M;
  real xxx_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA(time) M;
  real Acetoacetyl_minus_CoA(time) M;
  real xxx_space_2_minus_Acetolactate(time) M;
  real xxx_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA(time) M;
  real xxx_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate(time) M;
  real Thiamin_space_diphosphate(time) M;
  real Pyruvate(time) M;
  real Acetyl_minus_CoA(time) M;
  real R01976(time) katal;
  extern real R01976.kf;
  extern real R01976.kb;
  real R05119(time) katal;
  extern real R05119.kf;
  extern real R05119.kb;
  real R01975(time) katal;
  extern real R01975.kf;
  extern real R01975.kb;
  real R03050(time) katal;
  extern real R03050.kf;
  extern real R03050.kb;
  real R03026(time) katal;
  extern real R03026.kf;
  extern real R03026.kb;
  real R00410(time) katal;
  extern real R00410.kf;
  extern real R00410.kb;
  real R01171(time) katal;
  extern real R01171.kf;
  extern real R01171.kb;
  real R00014(time) katal;
  extern real R00014.kf;
  extern real R00014.kb;
  real R00408(time) katal;
  extern real R00408.kf;
  extern real R00408.kb;
  real R00238(time) katal;
  extern real R00238.kf;
  extern real R00238.kb;
  real R01360(time) katal;
  extern real R01360.kf;
  extern real R01360.kb;

  // equations
  when (time=time.min) xxx_space_3_minus_Butyn_minus_1_minus_al = 0;
  (xxx_space_3_minus_Butyn_minus_1_minus_al*uVol):time = -1*R05119;
  when (time=time.min) xxx_space_3_minus_Butynoate = 0;
  (xxx_space_3_minus_Butynoate*uVol):time = R05119;
  when (time=time.min) Succinate = 0;
  (Succinate*uVol):time = -1*R00408;
  when (time=time.min) Acetoacetate = 0;
  (Acetoacetate*uVol):time = -1*R00410 + R01360;
  when (time=time.min) Fumarate = 0;
  (Fumarate*uVol):time = R00408;
  when (time=time.min) Butanoyl_minus_CoA = 0;
  (Butanoyl_minus_CoA*uVol):time = -1*R01171;
  when (time=time.min) Crotonoyl_minus_CoA = 0;
  (Crotonoyl_minus_CoA*uVol):time = -1*R03026 + R01171;
  when (time=time.min) xxx_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA = 0;
  (xxx_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA*uVol):time = -1*R01976 + -1*R01975 + R03026;
  when (time=time.min) Acetoacetyl_minus_CoA = 0;
  (Acetoacetyl_minus_CoA*uVol):time = R01976 + R01975 + R00410 + R00238;
  when (time=time.min) xxx_space_2_minus_Acetolactate = 0;
  (xxx_space_2_minus_Acetolactate*uVol):time = -1*R03050;
  when (time=time.min) xxx_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA = 0;
  (xxx_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA*uVol):time = -1*R01360;
  when (time=time.min) xxx_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate = 0;
  (xxx_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate*uVol):time = R03050 + R00014;
  when (time=time.min) Thiamin_space_diphosphate = 0;
  (Thiamin_space_diphosphate*uVol):time = -1*R03050 + -1*R00014;
  when (time=time.min) Pyruvate = 0;
  (Pyruvate*uVol):time = -1*R00014;
  when (time=time.min) Acetyl_minus_CoA = 0;
  (Acetyl_minus_CoA*uVol):time = -1*R00238 + R01360;
  R01976 = R01976.kf*_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA - R01976.kb*Acetoacetyl_minus_CoA;
  R05119 = R05119.kf*_space_3_minus_Butyn_minus_1_minus_al - R05119.kb*_space_3_minus_Butynoate;
  R01975 = R01975.kf*_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA - R01975.kb*Acetoacetyl_minus_CoA;
  R03050 = R03050.kf*_space_2_minus_Acetolactate*Thiamin_space_diphosphate - R03050.kb*_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate;
  R03026 = R03026.kf*Crotonoyl_minus_CoA - R03026.kb*_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA;
  R00410 = R00410.kf*Acetoacetate - R00410.kb*Acetoacetyl_minus_CoA;
  R01171 = R01171.kf*Butanoyl_minus_CoA - R01171.kb*Crotonoyl_minus_CoA;
  R00014 = R00014.kf*Pyruvate*Thiamin_space_diphosphate - R00014.kb*_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate;
  R00408 = R00408.kf*Succinate - R00408.kb*Fumarate;
  R00238 = R00238.kf*Acetyl_minus_CoA - R00238.kb*Acetoacetyl_minus_CoA;
  R01360 = R01360.kf*_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA - R01360.kb*Acetyl_minus_CoA*Acetoacetate;

  // variable properties
  default.sbmlRole="compartment";
  uVol.sbmlRole="compartment";
  E1_space_2_space_1_space_3.sbmlRole="species";
  E1_space_2_space_1_space_3.sbmlCompartment="uVol";
  E1_space_3_space_99_space_1.sbmlRole="species";
  E1_space_3_space_99_space_1.sbmlCompartment="uVol";
  E2_space_8_space_3_space_5.sbmlRole="species";
  E2_space_8_space_3_space_5.sbmlCompartment="uVol";
  E1_space_3_space_99_space_2.sbmlRole="species";
  E1_space_3_space_99_space_2.sbmlCompartment="uVol";
  E1_space_1_space_1_space_35.sbmlRole="species";
  E1_space_1_space_1_space_35.sbmlCompartment="uVol";
  E4_space_2_space_1_space_17.sbmlRole="species";
  E4_space_2_space_1_space_17.sbmlCompartment="uVol";
  E1_space_1_space_1_space_157.sbmlRole="species";
  E1_space_1_space_1_space_157.sbmlCompartment="uVol";
  E2_space_2_space_1_space_6.sbmlRole="species";
  E2_space_2_space_1_space_6.sbmlCompartment="uVol";
  E2_space_3_space_1_space_9.sbmlRole="species";
  E2_space_3_space_1_space_9.sbmlCompartment="uVol";
  E4_space_1_space_3_space_4.sbmlRole="species";
  E4_space_1_space_3_space_4.sbmlCompartment="uVol";
  E1_space_2_space_4_space_1.sbmlRole="species";
  E1_space_2_space_4_space_1.sbmlCompartment="uVol";
  xxx_space_3_minus_Butyn_minus_1_minus_al.sbmlRole="species";
  xxx_space_3_minus_Butyn_minus_1_minus_al.sbmlName="_space_3_minus_Butyn_minus_1_minus_al";
  xxx_space_3_minus_Butyn_minus_1_minus_al.sbmlCompartment="uVol";
  xxx_space_3_minus_Butynoate.sbmlRole="species";
  xxx_space_3_minus_Butynoate.sbmlName="_space_3_minus_Butynoate";
  xxx_space_3_minus_Butynoate.sbmlCompartment="uVol";
  Succinate.sbmlRole="species";
  Succinate.sbmlCompartment="uVol";
  Acetoacetate.sbmlRole="species";
  Acetoacetate.sbmlCompartment="uVol";
  Fumarate.sbmlRole="species";
  Fumarate.sbmlCompartment="uVol";
  Butanoyl_minus_CoA.sbmlRole="species";
  Butanoyl_minus_CoA.sbmlCompartment="uVol";
  Crotonoyl_minus_CoA.sbmlRole="species";
  Crotonoyl_minus_CoA.sbmlCompartment="uVol";
  xxx_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA.sbmlRole="species";
  xxx_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA.sbmlName="_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA";
  xxx_space_S_space__minus_3_minus_Hydroxybutanoyl_minus_CoA.sbmlCompartment="uVol";
  Acetoacetyl_minus_CoA.sbmlRole="species";
  Acetoacetyl_minus_CoA.sbmlCompartment="uVol";
  xxx_space_2_minus_Acetolactate.sbmlRole="species";
  xxx_space_2_minus_Acetolactate.sbmlName="_space_2_minus_Acetolactate";
  xxx_space_2_minus_Acetolactate.sbmlCompartment="uVol";
  xxx_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA.sbmlRole="species";
  xxx_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA.sbmlName="_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA";
  xxx_space_S_space__minus_3_minus_Hydroxy_minus_3_minus_methylglutaryl_minus_CoA.sbmlCompartment="uVol";
  xxx_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate.sbmlRole="species";
  xxx_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate.sbmlName="_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate";
  xxx_space_2_minus__space__alpha__minus_Hydroxyethyl_space_thiamine_space_diphosphate.sbmlCompartment="uVol";
  Thiamin_space_diphosphate.sbmlRole="species";
  Thiamin_space_diphosphate.sbmlCompartment="uVol";
  Pyruvate.sbmlRole="species";
  Pyruvate.sbmlCompartment="uVol";
  Acetyl_minus_CoA.sbmlRole="species";
  Acetyl_minus_CoA.sbmlCompartment="uVol";
  R01976.sbmlRole="rate";
  R01976.kf.sbmlRole="rate";
  R01976.kb.sbmlRole="rate";
  R05119.sbmlRole="rate";
  R05119.kf.sbmlRole="rate";
  R05119.kb.sbmlRole="rate";
  R01975.sbmlRole="rate";
  R01975.kf.sbmlRole="rate";
  R01975.kb.sbmlRole="rate";
  R03050.sbmlRole="rate";
  R03050.kf.sbmlRole="rate";
  R03050.kb.sbmlRole="rate";
  R03026.sbmlRole="rate";
  R03026.kf.sbmlRole="rate";
  R03026.kb.sbmlRole="rate";
  R00410.sbmlRole="rate";
  R00410.kf.sbmlRole="rate";
  R00410.kb.sbmlRole="rate";
  R01171.sbmlRole="rate";
  R01171.kf.sbmlRole="rate";
  R01171.kb.sbmlRole="rate";
  R00014.sbmlRole="rate";
  R00014.kf.sbmlRole="rate";
  R00014.kb.sbmlRole="rate";
  R00408.sbmlRole="rate";
  R00408.kf.sbmlRole="rate";
  R00408.kb.sbmlRole="rate";
  R00238.sbmlRole="rate";
  R00238.kf.sbmlRole="rate";
  R00238.kb.sbmlRole="rate";
  R01360.sbmlRole="rate";
  R01360.kf.sbmlRole="rate";
  R01360.kb.sbmlRole="rate";
}