// This model generated automatically from SBML
// WARNING: Renamed variable _space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate to xxx_space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate due to JSim namespace restrictions
// WARNING: Renamed variable _space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_ to xxx_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_ due to JSim namespace restrictions
// WARNING: Renamed variable _space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide to xxx_space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide due to JSim namespace restrictions
// WARNING: Renamed variable _space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate to xxx_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate due to JSim namespace restrictions

// unit definitions
import nsrunit;
unit conversion off;

// SBML property definitions
property sbmlRole=string;
property sbmlName=string;
property sbmlCompartment=string;

// SBML reactions
// R04035: Phosphoribosyl_minus_ATP <=> Phosphoribosyl_minus_AMP 
// R03457: D_minus_erythro_minus_1_minus__space_Imidazol_minus_4_minus_yl_space_glycerol_space_3_minus_phosphate <=> _space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate 
// R03655: L_minus_Histidine <=> L_minus_Histidyl_minus_tRNA_space_His_space_ 
// R04558: N_minus__space_5_space__minus_Phospho_minus_D_minus_1_space__minus_ribulosylformimino_space__minus_5_minus_amino_minus_1_minus__space_5_space__space__minus_phospho_minus_D_minus_ <=> _space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide D_minus_erythro_minus_1_minus__space_Imidazol_minus_4_minus_yl_space_glycerol_space_3_minus_phosphate 
// R04640: _space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_ <=> N_minus__space_5_space__minus_Phospho_minus_D_minus_1_space__minus_ribulosylformimino_space__minus_5_minus_amino_minus_1_minus__space_5_space__space__minus_phospho_minus_D_minus_ 
// R01163: L_minus_Histidinal <=> L_minus_Histidine 
// R04037: Phosphoribosyl_minus_AMP <=> _space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_ 
// R03243: L_minus_Histidinol_space_phosphate => _space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate 
// R01168: L_minus_Histidine <=> Urocanate 
// R01071: Phosphoribosyl_minus_ATP => _space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate 

math main {
  realDomain time second;
  time.min=0;
  extern time.max;
  extern time.delta;

  // variable definitions
  real default = 1 L;
  real uVol = 1 L;
  real E2_space_4_space_2_space_17 = 0 M;
  real E3_space_6_space_1_space_31 = 0 M;
  real E3_space_5_space_4_space_19 = 0 M;
  real E5_space_3_space_1_space_16 = 0 M;
  real E4_space_1_space_3_space__minus_ = 0 M;
  real E4_space_2_space_1_space_19 = 0 M;
  real E2_space_6_space_1_space_9 = 0 M;
  real E4_space_3_space_1_space_3 = 0 M;
  real E1_space_1_space_1_space_23 = 0 M;
  real E6_space_1_space_1_space_21 = 0 M;
  real xxx_space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate(time) M;
  real Phosphoribosyl_minus_ATP(time) M;
  real Phosphoribosyl_minus_AMP(time) M;
  real xxx_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_(time) M;
  real N_minus__space_5_space__minus_Phospho_minus_D_minus_1_space__minus_ribulosylformimino_space__minus_5_minus_amino_minus_1_minus__space_5_space__space__minus_phospho_minus_D_minus_(time) M;
  real xxx_space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide(time) M;
  real D_minus_erythro_minus_1_minus__space_Imidazol_minus_4_minus_yl_space_glycerol_space_3_minus_phosphate(time) M;
  real xxx_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate(time) M;
  real L_minus_Histidinol_space_phosphate(time) M;
  real L_minus_Histidine(time) M;
  real Urocanate(time) M;
  real L_minus_Histidinal(time) M;
  real L_minus_Histidyl_minus_tRNA_space_His_space_(time) M;
  real R04035(time) katal;
  extern real R04035.kf;
  extern real R04035.kb;
  real R03457(time) katal;
  extern real R03457.kf;
  extern real R03457.kb;
  real R03655(time) katal;
  extern real R03655.kf;
  extern real R03655.kb;
  real R04558(time) katal;
  extern real R04558.kf;
  extern real R04558.kb;
  real R04640(time) katal;
  extern real R04640.kf;
  extern real R04640.kb;
  real R01163(time) katal;
  extern real R01163.kf;
  extern real R01163.kb;
  real R04037(time) katal;
  extern real R04037.kf;
  extern real R04037.kb;
  real R03243(time) katal;
  extern real R03243.kf;
  extern real R03243.kb;
  real R01168(time) katal;
  extern real R01168.kf;
  extern real R01168.kb;
  real R01071(time) katal;
  extern real R01071.kf;
  extern real R01071.kb;

  // equations
  when (time=time.min) xxx_space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate = 0;
  (xxx_space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate*uVol):time = R01071;
  when (time=time.min) Phosphoribosyl_minus_ATP = 0;
  (Phosphoribosyl_minus_ATP*uVol):time = -1*R04035 + -1*R01071;
  when (time=time.min) Phosphoribosyl_minus_AMP = 0;
  (Phosphoribosyl_minus_AMP*uVol):time = R04035 + -1*R04037;
  when (time=time.min) xxx_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_ = 0;
  (xxx_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_*uVol):time = -1*R04640 + R04037;
  when (time=time.min) N_minus__space_5_space__minus_Phospho_minus_D_minus_1_space__minus_ribulosylformimino_space__minus_5_minus_amino_minus_1_minus__space_5_space__space__minus_phospho_minus_D_minus_ = 0;
  (N_minus__space_5_space__minus_Phospho_minus_D_minus_1_space__minus_ribulosylformimino_space__minus_5_minus_amino_minus_1_minus__space_5_space__space__minus_phospho_minus_D_minus_*uVol):time = -1*R04558 + R04640;
  when (time=time.min) xxx_space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide = 0;
  (xxx_space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide*uVol):time = R04558;
  when (time=time.min) D_minus_erythro_minus_1_minus__space_Imidazol_minus_4_minus_yl_space_glycerol_space_3_minus_phosphate = 0;
  (D_minus_erythro_minus_1_minus__space_Imidazol_minus_4_minus_yl_space_glycerol_space_3_minus_phosphate*uVol):time = -1*R03457 + R04558;
  when (time=time.min) xxx_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate = 0;
  (xxx_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate*uVol):time = R03457 + R03243;
  when (time=time.min) L_minus_Histidinol_space_phosphate = 0;
  (L_minus_Histidinol_space_phosphate*uVol):time = -1*R03243;
  when (time=time.min) L_minus_Histidine = 0;
  (L_minus_Histidine*uVol):time = -1*R03655 + R01163 + -1*R01168;
  when (time=time.min) Urocanate = 0;
  (Urocanate*uVol):time = R01168;
  when (time=time.min) L_minus_Histidinal = 0;
  (L_minus_Histidinal*uVol):time = -1*R01163;
  when (time=time.min) L_minus_Histidyl_minus_tRNA_space_His_space_ = 0;
  (L_minus_Histidyl_minus_tRNA_space_His_space_*uVol):time = R03655;
  R04035 = R04035.kf*Phosphoribosyl_minus_ATP - R04035.kb*Phosphoribosyl_minus_AMP;
  R03457 = R03457.kf*D_minus_erythro_minus_1_minus__space_Imidazol_minus_4_minus_yl_space_glycerol_space_3_minus_phosphate - R03457.kb*_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate;
  R03655 = R03655.kf*L_minus_Histidine - R03655.kb*L_minus_Histidyl_minus_tRNA_space_His_space_;
  R04558 = R04558.kf*N_minus__space_5_space__minus_Phospho_minus_D_minus_1_space__minus_ribulosylformimino_space__minus_5_minus_amino_minus_1_minus__space_5_space__space__minus_phospho_minus_D_minus_ - R04558.kb*_space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide*D_minus_erythro_minus_1_minus__space_Imidazol_minus_4_minus_yl_space_glycerol_space_3_minus_phosphate;
  R04640 = R04640.kf*_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_ - R04640.kb*N_minus__space_5_space__minus_Phospho_minus_D_minus_1_space__minus_ribulosylformimino_space__minus_5_minus_amino_minus_1_minus__space_5_space__space__minus_phospho_minus_D_minus_;
  R01163 = R01163.kf*L_minus_Histidinal - R01163.kb*L_minus_Histidine;
  R04037 = R04037.kf*Phosphoribosyl_minus_AMP - R04037.kb*_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_;
  R03243 = R03243.kf*L_minus_Histidinol_space_phosphate - R03243.kb*_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate;
  R01168 = R01168.kf*L_minus_Histidine - R01168.kb*Urocanate;
  R01071 = R01071.kf*Phosphoribosyl_minus_ATP - R01071.kb*_space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate;

  // variable properties
  default.sbmlRole="compartment";
  uVol.sbmlRole="compartment";
  E2_space_4_space_2_space_17.sbmlRole="species";
  E2_space_4_space_2_space_17.sbmlCompartment="uVol";
  E3_space_6_space_1_space_31.sbmlRole="species";
  E3_space_6_space_1_space_31.sbmlCompartment="uVol";
  E3_space_5_space_4_space_19.sbmlRole="species";
  E3_space_5_space_4_space_19.sbmlCompartment="uVol";
  E5_space_3_space_1_space_16.sbmlRole="species";
  E5_space_3_space_1_space_16.sbmlCompartment="uVol";
  E4_space_1_space_3_space__minus_.sbmlRole="species";
  E4_space_1_space_3_space__minus_.sbmlCompartment="uVol";
  E4_space_2_space_1_space_19.sbmlRole="species";
  E4_space_2_space_1_space_19.sbmlCompartment="uVol";
  E2_space_6_space_1_space_9.sbmlRole="species";
  E2_space_6_space_1_space_9.sbmlCompartment="uVol";
  E4_space_3_space_1_space_3.sbmlRole="species";
  E4_space_3_space_1_space_3.sbmlCompartment="uVol";
  E1_space_1_space_1_space_23.sbmlRole="species";
  E1_space_1_space_1_space_23.sbmlCompartment="uVol";
  E6_space_1_space_1_space_21.sbmlRole="species";
  E6_space_1_space_1_space_21.sbmlCompartment="uVol";
  xxx_space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate.sbmlRole="species";
  xxx_space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate.sbmlName="_space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate";
  xxx_space_5_minus_Phospho_minus__alpha__minus_D_minus_ribose_space_1_minus_diphosphate.sbmlCompartment="uVol";
  Phosphoribosyl_minus_ATP.sbmlRole="species";
  Phosphoribosyl_minus_ATP.sbmlCompartment="uVol";
  Phosphoribosyl_minus_AMP.sbmlRole="species";
  Phosphoribosyl_minus_AMP.sbmlCompartment="uVol";
  xxx_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_.sbmlRole="species";
  xxx_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_.sbmlName="_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_";
  xxx_space_5_minus__space_5_minus_Phospho_minus_D_minus_ribosylaminoformimino_space__minus_1_minus__space_5_minus_phosphoribosyl_space__minus_.sbmlCompartment="uVol";
  N_minus__space_5_space__minus_Phospho_minus_D_minus_1_space__minus_ribulosylformimino_space__minus_5_minus_amino_minus_1_minus__space_5_space__space__minus_phospho_minus_D_minus_.sbmlRole="species";
  N_minus__space_5_space__minus_Phospho_minus_D_minus_1_space__minus_ribulosylformimino_space__minus_5_minus_amino_minus_1_minus__space_5_space__space__minus_phospho_minus_D_minus_.sbmlCompartment="uVol";
  xxx_space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide.sbmlRole="species";
  xxx_space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide.sbmlName="_space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide";
  xxx_space_1_minus__space_5_space__minus_Phosphoribosyl_space__minus_5_minus_amino_minus_4_minus_imidazolecarboxamide.sbmlCompartment="uVol";
  D_minus_erythro_minus_1_minus__space_Imidazol_minus_4_minus_yl_space_glycerol_space_3_minus_phosphate.sbmlRole="species";
  D_minus_erythro_minus_1_minus__space_Imidazol_minus_4_minus_yl_space_glycerol_space_3_minus_phosphate.sbmlCompartment="uVol";
  xxx_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate.sbmlRole="species";
  xxx_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate.sbmlName="_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate";
  xxx_space_3_minus__space_Imidazol_minus_4_minus_yl_space__minus_2_minus_oxopropyl_space_phosphate.sbmlCompartment="uVol";
  L_minus_Histidinol_space_phosphate.sbmlRole="species";
  L_minus_Histidinol_space_phosphate.sbmlCompartment="uVol";
  L_minus_Histidine.sbmlRole="species";
  L_minus_Histidine.sbmlCompartment="uVol";
  Urocanate.sbmlRole="species";
  Urocanate.sbmlCompartment="uVol";
  L_minus_Histidinal.sbmlRole="species";
  L_minus_Histidinal.sbmlCompartment="uVol";
  L_minus_Histidyl_minus_tRNA_space_His_space_.sbmlRole="species";
  L_minus_Histidyl_minus_tRNA_space_His_space_.sbmlCompartment="uVol";
  R04035.sbmlRole="rate";
  R04035.kf.sbmlRole="rate";
  R04035.kb.sbmlRole="rate";
  R03457.sbmlRole="rate";
  R03457.kf.sbmlRole="rate";
  R03457.kb.sbmlRole="rate";
  R03655.sbmlRole="rate";
  R03655.kf.sbmlRole="rate";
  R03655.kb.sbmlRole="rate";
  R04558.sbmlRole="rate";
  R04558.kf.sbmlRole="rate";
  R04558.kb.sbmlRole="rate";
  R04640.sbmlRole="rate";
  R04640.kf.sbmlRole="rate";
  R04640.kb.sbmlRole="rate";
  R01163.sbmlRole="rate";
  R01163.kf.sbmlRole="rate";
  R01163.kb.sbmlRole="rate";
  R04037.sbmlRole="rate";
  R04037.kf.sbmlRole="rate";
  R04037.kb.sbmlRole="rate";
  R03243.sbmlRole="rate";
  R03243.kf.sbmlRole="rate";
  R03243.kb.sbmlRole="rate";
  R01168.sbmlRole="rate";
  R01168.kf.sbmlRole="rate";
  R01168.kb.sbmlRole="rate";
  R01071.sbmlRole="rate";
  R01071.kf.sbmlRole="rate";
  R01071.kb.sbmlRole="rate";
}