// This model generated automatically from SBML
// WARNING: Renamed variable _space_10_minus_Formyltetrahydrofolate to xxx_space_10_minus_Formyltetrahydrofolate due to JSim namespace restrictions
// WARNING: Renamed variable _space_5_minus_Formyltetrahydrofolate to xxx_space_5_minus_Formyltetrahydrofolate due to JSim namespace restrictions
// WARNING: Renamed variable _space_5_space_10_minus_Methenyltetrahydrofolate to xxx_space_5_space_10_minus_Methenyltetrahydrofolate due to JSim namespace restrictions
// WARNING: Renamed variable _space_5_space_10_minus_Methylenetetrahydrofolate to xxx_space_5_space_10_minus_Methylenetetrahydrofolate due to JSim namespace restrictions
// WARNING: Renamed variable _space_5_minus_Methyltetrahydrofolate to xxx_space_5_minus_Methyltetrahydrofolate due to JSim namespace restrictions

// unit definitions
import nsrunit;
unit conversion off;

// SBML property definitions
property sbmlRole=string;
property sbmlName=string;
property sbmlCompartment=string;

// SBML reactions
// R01220: _space_5_space_10_minus_Methylenetetrahydrofolate => _space_5_space_10_minus_Methenyltetrahydrofolate 
// R02236: Folate => Dihydrofolate 
// R03940: _space_10_minus_Formyltetrahydrofolate <=> Tetrahydrofolate 
// R04560: _space_10_minus_Formyltetrahydrofolate => Tetrahydrofolate 
// R04326: Tetrahydrofolate <=> _space_5_space_10_minus_Methenyltetrahydrofolate 
// R02101: _space_5_space_10_minus_Methylenetetrahydrofolate => Dihydrofolate 
// R00944: _space_10_minus_Formyltetrahydrofolate <=> Tetrahydrofolate 
// R01655: _space_5_space_10_minus_Methenyltetrahydrofolate => _space_10_minus_Formyltetrahydrofolate 
// R00936: Tetrahydrofolate <=> Dihydrofolate 
// R04325: _space_10_minus_Formyltetrahydrofolate => Tetrahydrofolate 
// R00946: _space_5_minus_Methyltetrahydrofolate => Tetrahydrofolate 
// R02301: _space_5_minus_Formyltetrahydrofolate <=> _space_5_space_10_minus_Methenyltetrahydrofolate 
// R01224: _space_5_minus_Methyltetrahydrofolate <=> _space_5_space_10_minus_Methylenetetrahydrofolate 
// R04125: Tetrahydrofolate => _space_5_space_10_minus_Methylenetetrahydrofolate 
// R02300: _space_5_space_10_minus_Methenyltetrahydrofolate <=> _space_5_minus_Formyltetrahydrofolate 
// R00945: _space_5_space_10_minus_Methylenetetrahydrofolate => Tetrahydrofolate 

math main {
  realDomain time second;
  time.min=0;
  extern time.max;
  extern time.delta;

  // variable definitions
  real default = 1 L;
  real uVol = 1 L;
  real E1_space_5_space_1_space_3 = 0 M;
  real E2_space_1_space_2_space_3 = 0 M;
  real E2_space_1_space_2_space_2 = 0 M;
  real E3_space_5_space_1_space_10 = 0 M;
  real E2_space_1_space_2_space_9 = 0 M;
  real E2_space_1_space_1_space_13 = 0 M;
  real E2_space_1_space_1_space_45 = 0 M;
  real E2_space_1_space_2_space_10 = 0 M;
  real E2_space_1_space_2_space_1 = 0 M;
  real E3_space_5_space_4_space_9 = 0 M;
  real E6_space_3_space_3_space_2 = 0 M;
  real E1_space_5_space_1_space_5 = 0 M;
  real E1_space_5_space_1_space_20 = 0 M;
  real Folate(time) M;
  real Dihydrofolate(time) M;
  real Tetrahydrofolate(time) M;
  real xxx_space_10_minus_Formyltetrahydrofolate(time) M;
  real xxx_space_5_minus_Formyltetrahydrofolate(time) M;
  real xxx_space_5_space_10_minus_Methenyltetrahydrofolate(time) M;
  real xxx_space_5_space_10_minus_Methylenetetrahydrofolate(time) M;
  real xxx_space_5_minus_Methyltetrahydrofolate(time) M;
  real R01220(time) katal;
  extern real R01220.kf;
  extern real R01220.kb;
  real R02236(time) katal;
  extern real R02236.kf;
  extern real R02236.kb;
  real R03940(time) katal;
  extern real R03940.kf;
  extern real R03940.kb;
  real R04560(time) katal;
  extern real R04560.kf;
  extern real R04560.kb;
  real R04326(time) katal;
  extern real R04326.kf;
  extern real R04326.kb;
  real R02101(time) katal;
  extern real R02101.kf;
  extern real R02101.kb;
  real R00944(time) katal;
  extern real R00944.kf;
  extern real R00944.kb;
  real R01655(time) katal;
  extern real R01655.kf;
  extern real R01655.kb;
  real R00936(time) katal;
  extern real R00936.kf;
  extern real R00936.kb;
  real R04325(time) katal;
  extern real R04325.kf;
  extern real R04325.kb;
  real R00946(time) katal;
  extern real R00946.kf;
  extern real R00946.kb;
  real R02301(time) katal;
  extern real R02301.kf;
  extern real R02301.kb;
  real R01224(time) katal;
  extern real R01224.kf;
  extern real R01224.kb;
  real R04125(time) katal;
  extern real R04125.kf;
  extern real R04125.kb;
  real R02300(time) katal;
  extern real R02300.kf;
  extern real R02300.kb;
  real R00945(time) katal;
  extern real R00945.kf;
  extern real R00945.kb;

  // equations
  when (time=time.min) Folate = 0;
  (Folate*uVol):time = -1*R02236;
  when (time=time.min) Dihydrofolate = 0;
  (Dihydrofolate*uVol):time = R02236 + R02101 + R00936;
  when (time=time.min) Tetrahydrofolate = 0;
  (Tetrahydrofolate*uVol):time = R03940 + R04560 + -1*R04326 + R00944 + -1*R00936 + R04325 + R00946 + -1*R04125 + R00945;
  when (time=time.min) xxx_space_10_minus_Formyltetrahydrofolate = 0;
  (xxx_space_10_minus_Formyltetrahydrofolate*uVol):time = -1*R03940 + -1*R04560 + -1*R00944 + R01655 + -1*R04325;
  when (time=time.min) xxx_space_5_minus_Formyltetrahydrofolate = 0;
  (xxx_space_5_minus_Formyltetrahydrofolate*uVol):time = -1*R02301 + R02300;
  when (time=time.min) xxx_space_5_space_10_minus_Methenyltetrahydrofolate = 0;
  (xxx_space_5_space_10_minus_Methenyltetrahydrofolate*uVol):time = R01220 + R04326 + -1*R01655 + R02301 + -1*R02300;
  when (time=time.min) xxx_space_5_space_10_minus_Methylenetetrahydrofolate = 0;
  (xxx_space_5_space_10_minus_Methylenetetrahydrofolate*uVol):time = -1*R01220 + -1*R02101 + R01224 + R04125 + -1*R00945;
  when (time=time.min) xxx_space_5_minus_Methyltetrahydrofolate = 0;
  (xxx_space_5_minus_Methyltetrahydrofolate*uVol):time = -1*R00946 + -1*R01224;
  R01220 = R01220.kf*_space_5_space_10_minus_Methylenetetrahydrofolate - R01220.kb*_space_5_space_10_minus_Methenyltetrahydrofolate;
  R02236 = R02236.kf*Folate - R02236.kb*Dihydrofolate;
  R03940 = R03940.kf*_space_10_minus_Formyltetrahydrofolate - R03940.kb*Tetrahydrofolate;
  R04560 = R04560.kf*_space_10_minus_Formyltetrahydrofolate - R04560.kb*Tetrahydrofolate;
  R04326 = R04326.kf*Tetrahydrofolate - R04326.kb*_space_5_space_10_minus_Methenyltetrahydrofolate;
  R02101 = R02101.kf*_space_5_space_10_minus_Methylenetetrahydrofolate - R02101.kb*Dihydrofolate;
  R00944 = R00944.kf*_space_10_minus_Formyltetrahydrofolate - R00944.kb*Tetrahydrofolate;
  R01655 = R01655.kf*_space_5_space_10_minus_Methenyltetrahydrofolate - R01655.kb*_space_10_minus_Formyltetrahydrofolate;
  R00936 = R00936.kf*Tetrahydrofolate - R00936.kb*Dihydrofolate;
  R04325 = R04325.kf*_space_10_minus_Formyltetrahydrofolate - R04325.kb*Tetrahydrofolate;
  R00946 = R00946.kf*_space_5_minus_Methyltetrahydrofolate - R00946.kb*Tetrahydrofolate;
  R02301 = R02301.kf*_space_5_minus_Formyltetrahydrofolate - R02301.kb*_space_5_space_10_minus_Methenyltetrahydrofolate;
  R01224 = R01224.kf*_space_5_minus_Methyltetrahydrofolate - R01224.kb*_space_5_space_10_minus_Methylenetetrahydrofolate;
  R04125 = R04125.kf*Tetrahydrofolate - R04125.kb*_space_5_space_10_minus_Methylenetetrahydrofolate;
  R02300 = R02300.kf*_space_5_space_10_minus_Methenyltetrahydrofolate - R02300.kb*_space_5_minus_Formyltetrahydrofolate;
  R00945 = R00945.kf*_space_5_space_10_minus_Methylenetetrahydrofolate - R00945.kb*Tetrahydrofolate;

  // variable properties
  default.sbmlRole="compartment";
  uVol.sbmlRole="compartment";
  E1_space_5_space_1_space_3.sbmlRole="species";
  E1_space_5_space_1_space_3.sbmlCompartment="uVol";
  E2_space_1_space_2_space_3.sbmlRole="species";
  E2_space_1_space_2_space_3.sbmlCompartment="uVol";
  E2_space_1_space_2_space_2.sbmlRole="species";
  E2_space_1_space_2_space_2.sbmlCompartment="uVol";
  E3_space_5_space_1_space_10.sbmlRole="species";
  E3_space_5_space_1_space_10.sbmlCompartment="uVol";
  E2_space_1_space_2_space_9.sbmlRole="species";
  E2_space_1_space_2_space_9.sbmlCompartment="uVol";
  E2_space_1_space_1_space_13.sbmlRole="species";
  E2_space_1_space_1_space_13.sbmlCompartment="uVol";
  E2_space_1_space_1_space_45.sbmlRole="species";
  E2_space_1_space_1_space_45.sbmlCompartment="uVol";
  E2_space_1_space_2_space_10.sbmlRole="species";
  E2_space_1_space_2_space_10.sbmlCompartment="uVol";
  E2_space_1_space_2_space_1.sbmlRole="species";
  E2_space_1_space_2_space_1.sbmlCompartment="uVol";
  E3_space_5_space_4_space_9.sbmlRole="species";
  E3_space_5_space_4_space_9.sbmlCompartment="uVol";
  E6_space_3_space_3_space_2.sbmlRole="species";
  E6_space_3_space_3_space_2.sbmlCompartment="uVol";
  E1_space_5_space_1_space_5.sbmlRole="species";
  E1_space_5_space_1_space_5.sbmlCompartment="uVol";
  E1_space_5_space_1_space_20.sbmlRole="species";
  E1_space_5_space_1_space_20.sbmlCompartment="uVol";
  Folate.sbmlRole="species";
  Folate.sbmlCompartment="uVol";
  Dihydrofolate.sbmlRole="species";
  Dihydrofolate.sbmlCompartment="uVol";
  Tetrahydrofolate.sbmlRole="species";
  Tetrahydrofolate.sbmlCompartment="uVol";
  xxx_space_10_minus_Formyltetrahydrofolate.sbmlRole="species";
  xxx_space_10_minus_Formyltetrahydrofolate.sbmlName="_space_10_minus_Formyltetrahydrofolate";
  xxx_space_10_minus_Formyltetrahydrofolate.sbmlCompartment="uVol";
  xxx_space_5_minus_Formyltetrahydrofolate.sbmlRole="species";
  xxx_space_5_minus_Formyltetrahydrofolate.sbmlName="_space_5_minus_Formyltetrahydrofolate";
  xxx_space_5_minus_Formyltetrahydrofolate.sbmlCompartment="uVol";
  xxx_space_5_space_10_minus_Methenyltetrahydrofolate.sbmlRole="species";
  xxx_space_5_space_10_minus_Methenyltetrahydrofolate.sbmlName="_space_5_space_10_minus_Methenyltetrahydrofolate";
  xxx_space_5_space_10_minus_Methenyltetrahydrofolate.sbmlCompartment="uVol";
  xxx_space_5_space_10_minus_Methylenetetrahydrofolate.sbmlRole="species";
  xxx_space_5_space_10_minus_Methylenetetrahydrofolate.sbmlName="_space_5_space_10_minus_Methylenetetrahydrofolate";
  xxx_space_5_space_10_minus_Methylenetetrahydrofolate.sbmlCompartment="uVol";
  xxx_space_5_minus_Methyltetrahydrofolate.sbmlRole="species";
  xxx_space_5_minus_Methyltetrahydrofolate.sbmlName="_space_5_minus_Methyltetrahydrofolate";
  xxx_space_5_minus_Methyltetrahydrofolate.sbmlCompartment="uVol";
  R01220.sbmlRole="rate";
  R01220.kf.sbmlRole="rate";
  R01220.kb.sbmlRole="rate";
  R02236.sbmlRole="rate";
  R02236.kf.sbmlRole="rate";
  R02236.kb.sbmlRole="rate";
  R03940.sbmlRole="rate";
  R03940.kf.sbmlRole="rate";
  R03940.kb.sbmlRole="rate";
  R04560.sbmlRole="rate";
  R04560.kf.sbmlRole="rate";
  R04560.kb.sbmlRole="rate";
  R04326.sbmlRole="rate";
  R04326.kf.sbmlRole="rate";
  R04326.kb.sbmlRole="rate";
  R02101.sbmlRole="rate";
  R02101.kf.sbmlRole="rate";
  R02101.kb.sbmlRole="rate";
  R00944.sbmlRole="rate";
  R00944.kf.sbmlRole="rate";
  R00944.kb.sbmlRole="rate";
  R01655.sbmlRole="rate";
  R01655.kf.sbmlRole="rate";
  R01655.kb.sbmlRole="rate";
  R00936.sbmlRole="rate";
  R00936.kf.sbmlRole="rate";
  R00936.kb.sbmlRole="rate";
  R04325.sbmlRole="rate";
  R04325.kf.sbmlRole="rate";
  R04325.kb.sbmlRole="rate";
  R00946.sbmlRole="rate";
  R00946.kf.sbmlRole="rate";
  R00946.kb.sbmlRole="rate";
  R02301.sbmlRole="rate";
  R02301.kf.sbmlRole="rate";
  R02301.kb.sbmlRole="rate";
  R01224.sbmlRole="rate";
  R01224.kf.sbmlRole="rate";
  R01224.kb.sbmlRole="rate";
  R04125.sbmlRole="rate";
  R04125.kf.sbmlRole="rate";
  R04125.kb.sbmlRole="rate";
  R02300.sbmlRole="rate";
  R02300.kf.sbmlRole="rate";
  R02300.kb.sbmlRole="rate";
  R00945.sbmlRole="rate";
  R00945.kf.sbmlRole="rate";
  R00945.kb.sbmlRole="rate";
}