Capillary-tissue unit using serial stirred tanks with passive exchange via both a passive linear and a saturable transporter
Model number: 0264
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N well stirred tanks (i.e. compartmental models with flow) representing the capillary region are connected in series and exchange with N stagnant tanks in parallel representing the extravascular region. The exchange is via both a passive linear and a saturable Michaelis-Menten transporter.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
Schwartz L.M, Bukowski T.R, Ploger J.D, Bassingthwaighte J.B., Endothelial adenosine transporter characterization in perfused guinea pig hearts. Am. J. Physiol. Heart Circ. Physiol. 279, H1502-H1511, 2000.
CTEX20 models:CTEX20: Basic CTEX20 Model
CTEX20b: Additional extravascular exchange with Michaelis-Menten transporter
CTEX20c: Additional extravascular exchange with adenosine and inosine competing for saturable Michaelis-Menten transporter. Includes CTEX10 for reference intravascular solute (albumin)
See also:BTEX20: Distributed 2 region PDE model
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[This page was last modified 14Mar18, 3:17 pm.]
Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.