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Cardiac Physiome Society workshop: November 6-9, 2017 , Toronto

CTEX20b

Capillary-tissue unit using serial stirred tanks with passive exchange via both a passive linear and a saturable transporter

Model number: 0264

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Description

N well stirred tanks (i.e. compartmental models with flow) representing the capillary region are connected in series and exchange with N stagnant tanks in parallel representing the extravascular region. The exchange is via both a passive linear and a saturable Michaelis-Menten transporter.

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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References

Schwartz L.M, Bukowski T.R, Ploger J.D, Bassingthwaighte J.B., Endothelial adenosine transporter characterization in perfused guinea pig hearts. Am. J. Physiol. Heart Circ. Physiol. 279, H1502-H1511, 2000.

Related Models

CTEX20 models:

CTEX20: Basic CTEX20 Model 
CTEX20b: Additional extravascular exchange with Michaelis-Menten transporter 
CTEX20c: Additional extravascular exchange with adenosine and inosine competing for saturable Michaelis-Menten transporter. Includes CTEX10 for reference intravascular solute (albumin)  

See also:

BTEX20: Distributed 2 region PDE model 

Key Terms

CTEX20, BTEX20, Compartmental, Stirred Tanks, transporter, Michaelis-Menten, saturable, Tutorial

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Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 2:28 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.