Four-compartment whole body model with recirculation: repeated injections and first order hepatic clearance of Indocyanine Green dye.
Model number: 0103
|Run Model: ||    Help running a JSim model.|
(JSim model applet may take 10-20 seconds to load.)
Figure: Time course of ICG clearance during multiple injections of ICG over the course of 240 minutes.
Green line is model simulation results, triangles are Edwards 1960 figure 1 data, and black lines
are injections of ICG (for timing purposes only).
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
- Edwards AWT, Bassingthwaighte JB, Sutterer WF, and Wood EH. Blood level of indocyanine green in the dog during multiple dye curves and its effect on instrumental calibration. Proc S M Mayo Clin 35: 747-751, 1960.
- Edwards AWT, Isaacson J, Sutterer WF, Bassingthwaighte JB, and Wood EH. Indocyanine green densitometry in flowing blood compensated for background dye. J Appl Physiol 18: 1294-1304, 1963.
We welcome comments and feedback for this model. Please use the button below to send comments:
Model HistoryGet Model history in CVS.
Posted by: BEJ
Please cite www.physiome.org in any publication for which this software is used and send an email
with the citation and, if possible, a PDF file of the paper to: firstname.lastname@example.org.
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
[This page was last modified 14Mar18, 3:17 pm.]
Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.