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Comp6Propofol

A physiological model of induction of anaesthesia with propofol in sheep.

Model number: 0266

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Description

From the abstract of the paper (see first reference): "We describe a six-compartment physiological model of the kinetics and dynamics of induction of anaesthesia with propofol in sheep. It includes a faithful description of initial bolus kinetics caused by accurate representations of the inter-relationships between initial vascular mixing, lung kinetics and cardiac output, the use of the brain as the target organ for propofol anaesthesia (two-compartment sub-model with slight membrane limitation), a description of the effects of propofol-induced changes in cerebral blood flow and a combined description of systemic kinetics as two tissue pools. Variables for the model were estimated from an extensive in vivo data set using hybrid modelling. Propofol was characterized by rapid transit through the lungs, but a slower transit time though the brain, leading to significant delay between arterial blood concentrations and cerebral effects."

Powerpoint presentation on model by Jinfei Yu (2006) as a part of a final project at the University of Washington.

Equations

G. L. Ludbrook and R. N. Upton. A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables. British Journal of Anaesthesia, Vol 79, Issue 4 497-504.

The equations for this model may also be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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References

G. L. Ludbrook and R. N. Upton. A physiological model of induction of anaesthesia with propofol in sheep. 1. Structure and estimation of variables. British Journal of Anaesthesia, Vol 79, Issue 4 497-504.

G. L. Ludbrook and R. N. Upton. A physiological model of induction of anaesthesia with propofol in sheep. 2. Model analysis and implications for dose requirements. British Journal of Anaesthesia, Vol 79, Issue 4 505-513.

Upton, R.N., A model of the first pass passage of drums from i.v. injection site to the heart-parameter estimates for lignocaine in the shape, 1996 British J. of Anaesth, 77, 764-772.

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Key Terms

Compartment, compartmental, Comp6Propofol, propofol, anaesthesia, induction, pharmacokinetics, physiological, sheep, Tutorial, Data, Publication

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Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 2:27 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.