Two compartment model with feedback control of precursor (pregnenolone) to cortisol and its adrenal secretion.
Model number: 0102
|Run Model: ||    Help running a JSim model.|
(JSim model applet may take 10-20 seconds to load.)
This two compartment model for substances, Q1 (precursor) and Q2 (cortisol) is simplified from the original models of Urquhart (1968) by Jacquez (1972). Precursor Q1 is formed at a rate inhibited by itself at higher concentrations. Its conversion to cortisol is stimulated by ACTH, a saturable process. Increases in ACTH deplete PREG concentration and increase the secretion from the adrenal.
Figure: (Top) Concentration response of cortisol and precursor to ACTH infusion. Q1 is concentration of precurosr in compartment 1 and Q2 is cortisol concentration in compartment 2. (Bottom) ACTH input as a function of time.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
Urquhart J and Li CC. The dynamics of adrenocortical secretion. Am J Physiol 214: 73-85, 1968. Jacquez JA. Compartmental analysis in biology and medicine. Kinetics of distribution of tracer-labeled materials. Amsterdam: Elsevier Publishing Co., 1972, pp.237 (See pp 213-216) Jacquez JA. Compartmental analysis in biology and medicine. 3rd ed.. Ann Arbor, MI: BioMedware, 1996, 514 pp.
Single Compartment Models:
- Comp1Decay: Single Compartment with Decay,
- Comp1Flow: Single Compartment with Flow,
- Comp1FlowDecay: Single Compartment with Flow and Decay,
- Comp1Reaction: Single Compartment with One Reaction,
- Comp1FlowReaction: Single Compartment with Flow and One Reaction,
- Comp1FlowReactions2: Single Compartment with Flow and Two Reactions,
Two Compartment Models:
- Comp2Exchange: Two Compartments with Exchange,
- Comp2ExchangeReaction: Two Compartments with Exchange and One Reaction,
- Comp2FlowExchange: Two Compartments with Flow and Exchange Fit to a data set,
- Comp2FlowExchangeReaction: Two Compartments with Flow, Exchange, and One Reaction.
- Comp2FlowMMExchangeReaction: Two Compartments with Flow, Exchange using a Michaelis-Menten transporter, and One Reaction.
- Comp2FlowMRIContrast: Two Compartments with Flow, conversion of water to water spin for MRI contrast.
- Cortisol secretion: Two compartments with feedback control of precursor to cortisol and its adrenal secretion.
N>2 Compartment Models:
- Comp3FlowExch: Three compartmental model for plasma, interstitial fluid, and parenchymal cell,
- Comp6Propofol: Six compartmental model for propofol anaesthesia,
- CTEX10: N Compartments in series with Flow, emphasizes sensitivity analysis and optimization,
- CTEX10stat: CTEX10 model with statistics on inflow and outflow curves,
- CTEX20: N Compartments in series with Flow, each compartment exchanging with a compartment in parallel,
- CTEX20 5 path: Weighted sum of up to 5 paths of CTEX 20 modeled capillaries.
- CompNFlowDelay: N Compartments in series with Flow and Delay.
- Comp6_Recirc: Six compartmental recirculating model,
- Comp2x2Recirc: Dual two compartment models with recirculation and clearance,
- Uncoupled fluxes of water and solute across membrane.
- Uncoupled fluxes of water and solute across membrane w/ columns for measuring pressure.
- Transport of a hard spherical solute through a cylindrical pore.
- Washout curve simulation by sum of three decaying exponentials.
- Three reactions in series with no enzymes.
- Michaelis-Menton reactions in series.
- Enzymatic reactions in series.
- Four sequential enzymatic reactions.
We welcome comments and feedback for this model. Please use the button below to send comments:
Model HistoryGet Model history in CVS.
Posted by: Name
Please cite www.physiome.org in any publication for which this software is used and send an email
with the citation and, if possible, a PDF file of the paper to: email@example.com.
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
[This page was last modified 02Nov16, 2:28 pm.]
Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.