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PG_Isomerase

Single substrate single product reversible enzymatic reaction with parameters for phospho-gluco isomerase in erythrocytes (Ref 1)

Model number: 0271

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Description

  Single substrate single product reversible enzymatic reaction with 
  parameters for phospho-gluco isomerase in erythrocytes (Ref 1).
  Follows the Haldane constraint that the reaction is reversible
  and there is an equilibrium ratio of concentrations given by
  Kappa = [P]/[S] at equil = k1*k2/(k_1*k_2),  Eq 10-29 in 
  Bassingthwaighte's Chapter 10 on Metabolism.(Ref 2)

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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References

  Mulquiney PJ and Kuchel PW. Model of 2,3-bisphosphoglycerate metabolism 
  in the human erythrocyte  based on detailed enzyme kinetic equations: 
  equations and parameter refinement. Biochem J 342: 581-596, 1999 

  Bassingthwaighte, JB, Ch 10 Enzymes and Metabolic Reactions in "Transport in 
   Biological Systems" Springer ( in preparation )

 RELATED MODELS: #130 One_Enzyme_Reversible.proj

Related Models

One Enzyme - reversible

Key Terms

Transport Physiology, Chemical Reaction Enzymes, Enzymatic Reaction, Single Enzyme, Reversible, Michaelis-Menten Kinetics, Briggs-Haldane Kinetics, Tutorial, PK-PD, Pharmacokinetics

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Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 2:40 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.