# Progress3.MM

Sequence of two catalyzed 1st order Michaelis Menten-type irreversible reactions.

Model number: 0270

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## Description

Two irreversible reactions are governed by Michaelis-Menten kinetics. Consider the following two cases for the first reaction, dA/dt = -VmaxA*A/(KmA+A) : Case 1: A<<KmA, The reaction rate is ~VmaxA/Kma and the flux is VmaxA*(A/KmA)<<VmaxA. Case 2: A>>KmA. The reaction rate is ~VmaxA/A and the flux is VmaxA. The reaction rate is slowest when A<<KmA. The flux is greatest when A>>KmA.Figure plots concentration (mM) as a function of time of substrate A and its reaction products B and C.

## Equations

Where Concentrations and K_{m} are in mM, and V_{max} has units of mM/sec.

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## References

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## Key Terms

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## Model History

Get Model history in CVS.## Acknowledgements

Please cite **www.physiome.org** in any publication for which this software is used and send one reprint to the address given below:

The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 2:41 pm.]

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physiome.org provided by the following grants:** NIH/NIBIB BE08407 Software Integration,
JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ,
4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation,
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Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior
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