Mechanics of a rigid resistive bronchiole with compliant alveolar sac. The driving pressure is at entrance to the bronchiole; the reference extrathoracic pressure is constant at zero.
Model number: 0189
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This model represents a rigid bronchiole with a compliant alveolar sac. The resistance offered by bronchial wall to the flow of air is represented by the resistor in the model. The alveolar sac compliance is repsented by a capcitor. This model lacks the pleural pressure because of which a pressure pulse is used to drive the model.The pressure pulse represents the pressure difference in the alveolar space and the pleural sac. The alveolar sac changes its volume as a function of inlet flow or pressure. For a step function in the pressure the volume of the alveolar sac increases as an exponential function.
Finlet: Inlet Flow, P: Pressure, R: Resistance, F: Flow, Com: Compliance, V: Volume.
Pinlet - P2 = Finlet * R1 P2 - P3 = Finlet * R2 P3 - P4 = (V1 - V1_0)/Com1 d(V1)/dt = Finlet Where: P is pressure, F is flow, R is resistance, Com is capacitance, and V is the volume.
K. R. Lutchen and G. M. Saidel, "Estimation of mechanical parameters in multicompartment models applied to normal and obstructed lungs during tidal breathing," IEEE Trans. Biomed. Eng., vol. BME-33, no. 9, pp. 878-887, Sept. 1986. Levitzky MG. "Mechanics of Breathing", Pulmonary Physiology. 7th Edition, New York: McGraw-Hill, 2007, p. 11?53
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