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Cardiac Physiome Society workshop: November 6-9, 2017 , Toronto

Rigid_four_gen_weibel_lung

This model represents four generations of the bipodial human lung. The lengths and diameter of the airways are based on the weibel model. The compliance of the airway was considered to be negligible to represent rigid airways.

Model number: 0187

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Description

 This model represents four generations of the bipodial human lung. The lengths and diameter 
 of the airways are based on the weibel model. The resistance and the inductance of the 
 airway segments were calculated based on the article by Barbini P (See reference). 
 The capicitance of the lung was considered negligible representing a non-moving or a rigid 
 wall. The driving force of the model was a pressure gradient. A sinewave of amplitude 
 10 pa and time period of 2 seconds was prescribed at the inlet. The outlets were maintained 
 at zero pressure. The resistor in the electrical circuit represent the viscous effect 
 or resistance near the wall and the inductor represent the inertial resistance to air. 	



Figure: A four generation lung

Figure: Model represented as an electrical circuit. Only one bifurcating airway shown. See model source code for complete diagram.

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

Download JSim model project file

References

  Barbini, P, C. Brighenti, G. Cevenini,and G. Gnudi; A Dynamic Morphometric Model of 
  the Normal Lung for Studying Expiratory Flow Limitation in Mechanical Ventilation. 
  Ann. Biomed. Eng.Annals of Biomedical Engineering, Vol. 33, No. 4, May 2005, pp. 518–530

  Weibel, ER: Morphometry of the Human Lung. Berlin: Springer-Verlag, 1963.

	

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Key Terms

Weibel Lung, Bi-Podial Branching airways, Human Lung, rigid, Respiratory system, Respiratory mechanics, airway mechanics

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Posted by: bej

Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send an email with the citation and, if possible, a PDF file of the paper to: staff@physiome.org.
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 2:41 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.