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Surfactant effect on single bubble dynamics: This models the dynamic adsorption, desorption, and squeeze-out phenomena of surfactant

Model number: 0197

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 This models the dynamic adsorption, desorption, and squeeze-out 
phenomena of an exogenous pulmonary surfactant (surfactant TA) 
solution surrounding an oscillating bubble.
 The influence of the alveolar surface tension on the concentration
of the surfactant lining the alveolus can be simulated by this 
model describing the adsorption/desorption kinetics of a surfactant
on a bubble and the change in surface tension generated. The volume
of the bubble is driven in a sinusoidal manner.


The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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 Otis et al.; Dynamic surface tension of surfactant TA: 
experiments and theory. J Appl Physiol 77:2681-2688, 1994.

 Y.C. Fung; Biomechanics: Mechanical Properties of Living Tissues,
Second Edition, Springer-Verlag, New York, 1993, pp16-17

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Key Terms

lung alveolus, surface tension, bubble dynamics, surfactant TA concentration, lung compliance, functional residual volume, pulmonary mechanics, intrapleural pressure, lung elasticity, Respiratory mechanics, Airway mecahnics

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Posted by: BEJ


Please cite in any publication for which this software is used and send an email with the citation and, if possible, a PDF file of the paper to:
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 14Mar18, 3:17 pm.]

Model development and archiving support at provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.