First-order reversible enzymatic reaction with binding of either substrate or product to enzyme and allows thermodynamic equilibrium.
Model number: 0130
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where k1 is the forward binding rate of S to E, k-1 is the backwards reaction rate of ES dissociating to E and S, k2 is the forward reaction rate of ES forming E and P, and k-2 is the reverse reaction rate of E and P producing ES.
The backward reaction rates in this model are determined from the equilibrium dissociation rates of S binding to E and P binding to E and are given by:
where Ks is the equilibrium dissociation rate of S binding to E and Kp of p binding to E.
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Bassingthwaighte JB.: Enzymes and Metabolic Reactions, Chapter 10 in "Transport and Reactions in Biological Systems", Pages 7-8
- Competitive Inhibition
- One Enzyme - reversible
- One Enzyme - sequestered
- Two Enzyme - reversible
- Two Enzyme - sequestered
- Feedback inhibition
- Non-competitive inhibition
- Phospho-gluco isomerase - reversible
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The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.
[This page was last modified 02Jul12, 2:39 pm.]
Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.