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# HbCO2

Hemoglobin CO2 saturation curve at varied levels of PO2 and pH. Temperature and 2,3-DPG concentration are assumed constant. Based on Dash 2010 paper.

Model number: 0037

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## Description

Model to approximate CO2 saturation of hemoglobin (SHbCO2) is described here from the equilibrium binding of CO2 with hemoglobin inside RBCs. It is in the form of an invertible Hill-type equation with the apparent Hill coefficient KHbCO2 in the expression. SHbCO2 is dependent on the levels of O2 and CO2 partial pressures (PO2 and PCO2 ) and pH. The dependence on 2,3-DPG concentration and temperature in blood is assumed constant. Because of the mathematical simplicity and invertibility, these new formulas can be conveniently used in the modeling of simultaneous transport and exchange of O2 and CO2 in the alveoli-blood and blood-tissue exchange system.

## Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

## References

Dash RK and Bassingthwaighte JB.(Erratum Reprint of 2004 paper) Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels. Ann Biomed Eng 38: 1683-1701, 2010.

## Key Terms

hemoglobin, oxygen, carbon dioxide, saturation, Haldane, Bohr, acidity, pH, blood gases, Hill equation, solubility