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Cardiac Physiome Society workshop: November 6-9, 2017 , Toronto

HbO.WCM2state

The Monod-Wyman-Changeux model is used to describe the saturation of hemoglobin with oxygen. Accounts for homotropic cooperative effects on each of the four binding sites.

Model number: 0239

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Description

   The Monod-Wyman-Changeux model was first used to describe indirect interactions of neighboring
   binding sites (each protomer of a protein has exactly one binding site) on each other (allosteric effect). 
   It uses a simple model where the protein (Hemoglobin) can be found in one of at least two different, 
   reversible, conformational states. The affinity for the ligand (O2) is different for the two 
   conformational states. If a ligand binding to one site causes a confomational change of the protomer
   then the conformational change occurs for all protomers (binding sites). This model describes
   homotropic cooperative effects between binding sites but does not take into account heterotropic effects 
   due to different allosteric ligands (ex: 3 ligands where one is an inhibitor and one is an activator for 
   the third ligand). See Notes page for additional information.
	

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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References

	Monod J, Wyman J, Changeux J: On the Nature of Allosteric Transitions: A Plausible Model
        Journal of Molecular Biology, 12:88-118, 1965
	

Related Models

Key Terms

hemoglobin, oxygen, binding, cooperative binding, MWC, Monod-Wyman-Changeux, saturation curve, allosteric protein, Tutorial, Data, Publication

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Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 4:02 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.