Comp2.PSF
Model number: 0013
A two compartment passive fluid model.
Detailed Description
This is a two compartment model with flow (F), volumes (Vp and VISF), their respective concentrations (Cp and CISF), and an exchange coefficient PSc (an acronym for Permeability-Surface area product). The model is assummed to be instantaneously well mixed - that is, the concentration of the solute is consistant throughout the entire fluid. This model models the passive exchange between plasma and Interstitial Fluid (ISF), with an external input function, Cin.
Relevant Equations
 = \frac {F(C_{\text{\small{in}}} - C_{\text{\small{p}}})}{V_{\text{\small{p}}}} - \frac {PS_{\text{\small{c}}}(C_{\text{\small{p}}}-C_{\text{\small{ISF}}})}{V_{\text{\small{p}}}}})
 = \frac {PS_{\text{\small{c}}}(C_{\text{\small{p}}}-C_{\text{\small{ISF}}})}{V_{\text{\small{ISF}}}})
 = V_{\text{\small{p}}} C_{\text{\small{p}}} + V_{\text{\small{ISF}}} C_{\text{\small{ISF}}}})
 = F (C_{\text{\small{in}}}-C_{\text{\small{p}}}))
Where F is the flow, Vp is the volume of the top compartment with flow, VISF is the volume of the bottom compartment without flow, and Cp and CISF are the respective concentrations. PSc (Permeability-Surface area product) is the exchange rate between the compartments. Q is the quantity of solute in the system at any given time, with Q1 as the difference between integrals.
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References
Copyright (C) 1999-2009 University of Washington. From the National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061. Academic use is unrestricted. Software may be copied so long as this copyright notice is included. This software was developed with support from NIH grant HL073598. Please cite this grant in any publication for which this software is used and send one reprint to the address given above.
Related Models
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Key Terms
Compartmental Model, Flow and Exchange, Mixing Chamber, Permeability, PS/F, Washout, Inflow-Outflow opreator.ISF, Parenchymal Cell.
JSim Tutorial
Click here to go to a JSim tutorial webpage, with an introduction to the JSim GUI, detailed usage instructions, and an accompaying video.
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Model History
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Model development and archiving support at
physiome.org provided by the following grants: NIH/NHLBI T15
HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ,
4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation,
8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer
Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior
support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass
Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973
JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
Relevant Equations
Where F is the flow, Vp is the volume of the top compartment with flow, VISF is the volume of the bottom compartment without flow, and Cp and CISF are the respective concentrations. PSc (Permeability-Surface area product) is the exchange rate between the compartments. Q is the quantity of solute in the system at any given time, with Q1 as the difference between integrals.
Download File
Run JSim Model
Press the "Run Applet" button to bring up the model in a separate window.
References
Copyright (C) 1999-2009 University of Washington. From the National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061. Academic use is unrestricted. Software may be copied so long as this copyright notice is included. This software was developed with support from NIH grant HL073598. Please cite this grant in any publication for which this software is used and send one reprint to the address given above.
Related Models
Return to Transporter
Key Terms
Compartmental Model, Flow and Exchange, Mixing Chamber, Permeability, PS/F, Washout, Inflow-Outflow opreator.ISF, Parenchymal Cell.
JSim Tutorial
Click here to go to a JSim tutorial webpage, with an introduction to the JSim GUI, detailed usage instructions, and an accompaying video.
Model Feedback
We welcome comments and feedback for this model. Please use the button below to send comments:
Model History
Get Model history in CVS.
Model development and archiving support at
physiome.org provided by the following grants: NIH/NHLBI T15
HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ,
4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation,
8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer
Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior
support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass
Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973
JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
Where F is the flow, Vp is the volume of the top compartment with flow, VISF is the volume of the bottom compartment without flow, and Cp and CISF are the respective concentrations. PSc (Permeability-Surface area product) is the exchange rate between the compartments. Q is the quantity of solute in the system at any given time, with Q1 as the difference between integrals.
Download File
Run JSim Model
Press the "Run Applet" button to bring up the model in a separate window.
References
Copyright (C) 1999-2009 University of Washington. From the National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061. Academic use is unrestricted. Software may be copied so long as this copyright notice is included. This software was developed with support from NIH grant HL073598. Please cite this grant in any publication for which this software is used and send one reprint to the address given above.
Related Models
Return to Transporter
Key Terms
Compartmental Model, Flow and Exchange, Mixing Chamber, Permeability, PS/F, Washout, Inflow-Outflow opreator.ISF, Parenchymal Cell.
JSim Tutorial
Click here to go to a JSim tutorial webpage, with an introduction to the JSim GUI, detailed usage instructions, and an accompaying video.
Model Feedback
We welcome comments and feedback for this model. Please use the button below to send comments:
Model History
Get Model history in CVS.
Model development and archiving support at
physiome.org provided by the following grants: NIH/NHLBI T15
HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ,
4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation,
8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer
Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior
support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass
Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973
JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
Run JSim Model
Press the "Run Applet" button to bring up the model in a separate window.
References
Copyright (C) 1999-2009 University of Washington. From the National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061. Academic use is unrestricted. Software may be copied so long as this copyright notice is included. This software was developed with support from NIH grant HL073598. Please cite this grant in any publication for which this software is used and send one reprint to the address given above.
Related Models
Return to Transporter
Key Terms
Compartmental Model, Flow and Exchange, Mixing Chamber, Permeability, PS/F, Washout, Inflow-Outflow opreator.ISF, Parenchymal Cell.
JSim Tutorial
Click here to go to a JSim tutorial webpage, with an introduction to the JSim GUI, detailed usage instructions, and an accompaying video.
Model Feedback
We welcome comments and feedback for this model. Please use the button below to send comments:
Model History
Get Model history in CVS.
Model development and archiving support at
physiome.org provided by the following grants: NIH/NHLBI T15
HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ,
4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation,
8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer
Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior
support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass
Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973
JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
Related Models
Return to Transporter
Key Terms
Compartmental Model, Flow and Exchange, Mixing Chamber, Permeability, PS/F, Washout, Inflow-Outflow opreator.ISF, Parenchymal Cell.
JSim Tutorial
Click here to go to a JSim tutorial webpage, with an introduction to the JSim GUI, detailed usage instructions, and an accompaying video.
Model Feedback
We welcome comments and feedback for this model. Please use the button below to send comments:
Model History
Get Model history in CVS.
Model development and archiving support at
physiome.org provided by the following grants: NIH/NHLBI T15
HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ,
4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation,
8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer
Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior
support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass
Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973
JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
Key Terms
Compartmental Model, Flow and Exchange, Mixing Chamber, Permeability, PS/F, Washout, Inflow-Outflow opreator.ISF, Parenchymal Cell.
JSim Tutorial
Click here to go to a JSim tutorial webpage, with an introduction to the JSim GUI, detailed usage instructions, and an accompaying video.
Model Feedback
We welcome comments and feedback for this model. Please use the button below to send comments:
Model History
Get Model history in CVS.
Model development and archiving support at
physiome.org provided by the following grants: NIH/NHLBI T15
HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ,
4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation,
8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer
Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior
support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass
Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973
JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
JSim Tutorial
Model Feedback
We welcome comments and feedback for this model. Please use the button below to send comments:
Model History
Get Model history in CVS.Model development and archiving support at physiome.org provided by the following grants: NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
