Transp1sol
One solute transporter models.
These are a more standard model of facilitated transporter kinetics. Unlike the previous Michaelis-Menten models, binding of the solute to the transporter is not instantaneous. Constants are given for binding rates of the solute to the transporter, as well as unbinding rates (kon A1 and koff A1). We can assume transporter concentrations are negligible relative to the solute concentration. Transmembrane flip rates are also provided. These models account for single-site binding without competition from another solute (these models only deal with one solute).
Like enzymatic reactions, the flux is bidirectional. Unlike enzymes the "substrate" and "product" are identical. Unlike enzymes there is sidedness, and the substrate can be bound on either side of the membrane. Since in actuality a transporter molecule exposes its active site to only one side at a time, the transmembrane flip rate provides the driving force for the particular flux tat arises at certain concentrations.
Relevant Equations here.
One solute Transporter Models:
- One solute, 2 region.
- One solute, 2 region with flow.
- One solute, 2 region, and axially distributed, with flow.
References
Copyright (C) 1999-2009 University of Washington. From the National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061. Academic use is unrestricted. Software may be copied so long as this copyright notice is included. This software was developed with support from NIH grant HL073598. Please cite this grant in any publication for which this software is used and send one reprint to the address given above.
Key Terms
One solute, transmembrane flip rates, binding rates, facilitated transport.
JSim Tutorial
Click here to go to a JSim tutorial webpage, with an introduction to the JSim GUI, detailed usage instructions, and an accompaying video.Model development and archiving support at physiome.org provided by the following grants: NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
