Comparison of 1-sided and 2 sided Michaelis-Menten transporters in a two compartment model with flow.
Model number: 0018
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Figure 1: Concentrations of A1, A2, B1, and B2 are plotted as functions of time. The normalized values of PS (PSa/PSmax and PSb/PSmax) are also plotted as functions of time.
Two types of a saturable Michaelis-Menten transporter are considered in this two compartment model with flow--a one sided transporter for solute A and a two-sided transporter for solute B. The model for solute A is cis- side driven. Concentration of A in V1, A1, determines the fractional saturation, PSa/PSmax, where PSmax is Vmax/Km, and PSa = PSmax/(1 + A1/Km). The model for solute B is cis-trans driven. Concentration of B in both V1 and V2, B1 and B2 respectively, determine the fractional saturation, where PSmax is Vmax/Km and PSb = PSmax/(1 + B1/Km + B2/Km).