A two compartment one-sided Michaelis-Menten transporter.
Model number: 0014
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Compartmental models are based on mass balance equations. The compartment has a volume, V, and a time-varying concentration of a substance, C(t). An underlying assumption of compartmental models is that the material in the compartment is instantaneously well mixed. Compartmental models are also call well stirred tank models. This is a compartmental model for facilitated exchange between two chambers separated by a membrane. It is a closed model (no inflow or outflow), with volumes V1 and V2 for each compartment, time dependent concentrations A1(t) and A2(t) respectively, and an exchange coefficient PS. G2 is for Gulosity, the first order consumption of the solute in V2. This model assumes instantaneous solute binding to a Michaelis-Menten type transporter, with only a single site available from on the V1 side of the membrane. Fluxes are set by the concentration of A1(t) in V1. A1 determines the fractional saturation, PS/PSmax. See model TranspMM2sidedComp2.proj to compare with a transporter binding on either side of the membrane