Highly-integrated human with interventions
This is a closed loop cardiopulmonary system composed of a four-chamber varying-elastance heart, a pericardium, a systemic circulation, a pulmonary circulation, airways mechanics, baroreceptors, gas exchange, blood gas handling, coronary circulation, peripheral chemoreceptors and selectable interventions (Valsalva maneuver, pericardial removal, penetrating wounds to heart, septal defect, etc.).
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Key Terms: cardiovascular, pulmonary, cardiopulmonary, gas exchange, blood gas handling, pericardium, penetrating injuries, Valsalva maneuver, FVC maneuver, heart, systemic circulation, pulmonary circulation, coronary circulation, lumped parameter, baroreceptor, chemoreceptor, oxygen, carbon dioxide, bicarbonate, carboxyhemoglobin, pH, nitrogen, airway mechanics, integrated physiology
Maxwell Neal mneal@u.washington.edu
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Model development and archiving support at physiome.org provided by the following grants: NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
