http://www.physiome.org/model/ 2012-05-17T03:34:34-07:00 http://www.physiome.org/model/ http://www.physiome.org/model/lib/images/favicon.ico text/html 2011-11-22T12:34:08-07:00 Bart jardine http://www.physiome.org/model/doku.php?id=Endocrine_System:Hormones_of_pancreatic_islets:Insulin:Metabolic_Insulin_Signaling_Pathways:model_index&rev=1321994048&do=diff A mathematical model of metabolic insulin signaling pathways based on the work of Ahmad Sedaghat, Arthur Sherman and Michael Quon [2002, AM J Physiol Endocrinol Metab, 283,E1084-E1101]. The model was developed by Maris Lemba [2003] as a project for BIOEN 598, University of Washington. text/html 2011-11-14T14:46:48-07:00 Bart jardine http://www.physiome.org/model/doku.php?id=Cell_Physiology:Action_potential:Hodgkin_Huxley_1952:model_index&rev=1321310808&do=diff Hodgkin and Huxley (HH 1952d): Nerve action potential for squid giant axon. Quantitative model of time- and voltage-dependent transmembrane currents for Na, K, and a leak current, Ileak. Centerpiece for Nobel prize. Model moved to HERE. text/html 2011-11-07T12:37:13-07:00 Bart jardine http://www.physiome.org/model/doku.php?id=Transport_Physiology:Diffusion:Radial_Diffusion_in_Muscle_Fiber:model_index&rev=1320698233&do=diff This model simulates the diffusion of 11 cytosolic proteins from rabbit skinned muscle fibers into a bathing physiological solution. Several mechanisms which alter protein diffusion are considered including binding to the myofilament lattice, binding to the other proteins, hindrance due to lattice structure, and reduction to diffusion due to protein crowding. text/html 2011-11-02T11:21:18-07:00 Bart jardine http://www.physiome.org/model/doku.php?id=Transport_Physiology:Combined_convection_diffusion_permeation_reaction:Sanshe:model_index&rev=1320258078&do=diff The Sangren-Sheppard model (Bull Math Biophys 15: 387-394, 1953) for the exchange of a labeled substance between a liquid flowing in a vessel and an external compartment. Similar to BTEX20 with no diffusion. Model move to: TO HERE. text/html 2011-10-17T16:00:36-07:00 Bart jardine http://www.physiome.org/model/doku.php?id=Cardiovascular_System:Circulatory_networks:Pulmonary_Circulation_Olansen_et_al._2000:model_index&rev=1318892436&do=diff A model of pulmonary circulation based on Olansen et al. (2000) and Lu et al. (2001). A right ventricle input pressure pulse drives blood flow through the following vascular components: proximal pulmonary artery, distal pulmonary artery, pulmonary arterioles, pumonary capillaries and pulmonary veins. text/html 2011-10-17T10:20:16-07:00 Bart jardine http://www.physiome.org/model/doku.php?id=Integrative_Physiology:Highly-integrated_human_with_interventions:model_index&rev=1318872016&do=diff This is a closed loop cardiopulmonary system composed of a four-chamber varying-elastance heart, a pericardium, a systemic circulation, a pulmonary circulation, airways mechanics, baroreceptors, gas exchange, blood gas handling, coronary circulation, peripheral chemoreceptors and selectable interventions (Valsalva maneuver, pericardial removal, penetrating wounds to heart, septal defect, etc.). text/html 2011-10-12T15:20:18-07:00 Bart jardine http://www.physiome.org/model/doku.php?id=Respiratory_System:Respiratory_mechanics:Airway_mechanics:Rig_four_gen_weibel_lung:model_index&rev=1318458018&do=diff This model represents four generations of the bipodial human lung. The lengths and diameter of the airways are based on the weibel model. The compliance of the airway was considered to be negligible to represent rigid airways. Model moved To here. text/html 2011-10-03T14:31:03-07:00 Bart jardine http://www.physiome.org/model/doku.php?id=Respiratory_System:Air-blood_gas_exchange:Soluble_gas_exchange_Kumagai_2000:model_index&rev=1317677463&do=diff Simple compartmental model including soluble gas transport in the alveoli, transfer between the bronchial circulation and the conducting airways, and metabolism. Model moved to: Here. text/html 2011-09-27T14:29:56-07:00 Bart jardine http://www.physiome.org/model/doku.php?id=Transport_Physiology:Whole_organ_models:Goresky:Flow_limited_model:model_index&rev=1317158996&do=diff Back to Introduction Rapid exchange of solutes between the vascular and the extravascular space in a whole organ. Theory The liver sinusoids are lined by fenestrated endothelial cells. [sinusoid] The fenestrae are openings in the endothelial cells with a diameter of about 100 nm, much smaller than the diameter of an erythrocyte (ca. 7 µm). Therefore, erythrocytes do not cross the endothelium, they move along the sinusoids with the velocity of blood: