|ABSTRACTS AND POSTERS|
Welcome to the Cardiac Physiome Society's 20th Workshop
The Cardiac Physiome Society's annual meeting will be held at the University of Toronto, Canada in the fall of 2017 from Nov. 6th to Nov 9th.
There will be two parts. The central theme for the Nov. 7th and 8th sessions, building on the past emphasis on electrophysiology and mechanics, is on linking these to metabolism. The overt goal is to foster bridging “silos of knowledge” into conciliated structured knowledge linking metabolism, signaling, electrophysiology and mechanics, and mathematical models. Topics include:
The second part of the conference occurs on the 9th. Thursday morning, Nov 9 th, is a Tutorial/Technical session for which we invite suggestions now, from computational methods to experiments to research strategies.
CiPAThe Thursday afternoon session links Cardiac Physiome with CiPA (Comprehensive in-vitro Pro-arrhythmia Assay), an international initiative, launched in 2013 by the US Food and Drug Administration, other drug regulatory agencies, industry and academic collaborators, to develop and validate a new mechanistic, in vitro and in silico paradigm for evaluating the proarrhythmic risk of new drugs. CiPA studies include ion channel effects in cell lines combined with mathematical action potential modelling to predict the effect of multiple ion channel block and associated pro-arrhythmic risk, and to check the integrated effect with stem-cell derived cardiomyocyte measurements. The CiPA project website is http://cipaproject.org/