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(Matlab) Adenine nucleotide translocator (ANT)

Model number: 0408


 The primary function of Adenine nucleotide translocator (ANT) is to catalyze 
 ADP/ATP exchange across the inner membrane. Under respiring conditions, 
 ATP4− generated by oxidative phosphorylation is exported to the cytosol 
 for use in cellular activities and ADP3− is imported into the mitochondrial 
 matrix for continuous ATP synthesis. Ant is therefore an ADP3−/ATP4− exchanger.

 The two reactions involved in the ANT are:
 1. (cytoplasm) Creatine Kinase (EC
 Phosphocreatine + ADP + H+ <-> Creatine + ATP

 2. (Mito matrix) ATP Hydrolysis (EC
 ATP + H2O <-> ADP + Pi + H+
 Hydrolysis of ATP. 

 Model generated from The Biochemical Simulation Environment (BISEN).

Figure 1: Potential energy across mito membrane.

Figure 2: Progress curves of ATP and ADP in cytoplasm.

Figure 3: Progress curves of ATP and ADP in mito membrane matrix.


The equations for this model may be viewed opening the Matlab model below.

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Key Terms

TCA, enzyme, BISEN, Cardiac grid, proton, inorganic phosphate, hydrolysis, magnesium, potassium, Gibbs free energy, thermodynamics, Matlab, ANT, creatine, Phosphocreatine, ATP Hydrolysis, Creatine Kinase

Model History


Posted by: BEJ


Please cite in any publication for which this software is used and send an email with the citation and, if possible, a PDF file of the paper to:
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 29Jan20, 1:02 pm.]

Model development and archiving support at provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.