Four region, distributed model for the O2-CO2 transport, exchange and metabolism. From Dash 2006 paper. Annotated for use with MPC. Compute dissolved O2 and CO2 from total O2 and CO2 (TO2 and TCO2) through numerical inversion method that uses SHbO2CO2_EJAP2016 routine and Christmas 2017 O2/CO2 solubility algorithm. Incorporates Calculations for temperature changes based on consumption of O2 in parenchymal region.
Model number: 0434
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Four region model for the O2-CO2 transport, exchange and metabolism. Based on Dash et al 2006 and 2010 papers. Computes dissolved O2 and CO2 from total O2 and CO2 (TO2 and TCO2) through numerical inversion method using Dash et al. 2016 routine. O2 and CO2 gas solubility change with time and position based on Christmas et al. 2017 O2/CO2 solubility algorithm that incorporates temperature and density (or water space) into its solubility calculations. Incorporates calculations for temperature changes (time and position dependent) based on consumption of O2 generating heat in parenchymal cell (PC) region. Model incorporated into larger recirculating model (Model #405, RecircO2CO2BTEX_3CompLung).
Figure 1: Axial distribution of pO2 and pCO2 along tissue axis at t.max=100 s. rbc = red blood cells, pl = plasma region, isf = interstitial region, and pc = parenchymal cells (musscle cells). pO2 and pCO2 going into tissue: 100 mmHg and 40 mmHg respectively.
Figure 2: Axial distribution of hemoglobin saturation SHbO2(Blk) and SHbCO2(x20) along tissue axis at t.max=100 s. rbc = red blood cells, pl = plasma region, isf = interstitial region, and pc = parenchymal cells (musscle cells). pO2 and pCO2 going into tissue: 100 mmHg and 40 mmHg respectively.
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Yipintsoi T, Scanlon PD, and Bassingthwaighte JB. Density and water content of dog ventricular myocardium. Proc Soc Exp Biol Med 141: 1032-1035, 1972. Bassingthwaighte JB, Yipintsoi T, and Harvey RB. Microvasculature of the dog left ventricular myocardium. Microvasc Res 7: 229-249, 1974. Gonzalez F and Bassingthwaighte JB. Heterogeneities in regional volumes of distribution and flows in the rabbit heart. Am J Physiol Heart Circ Physiol 258: H1012-H1024, 1990. Vinnakota K and Bassingthwaighte JB. Myocardial density and composition: A basis for calculating intracellular metabolite concentrations. Am J Physiol Heart Circ Physiol 286: H1742-H1749, 2004. Bassingthwaighte JB and Vinnakota KC. The computational integrated myocyte. A view into the virtual heart. In: Modeling in Cardiovascular Systems. Ann. New York Acad. Sci. 1015:, edited by Sideman S. and Beyar R. 2004, pp 391-404. Brozek J, Grande F, Anderston JT, and Keys A. Densitometric analysis of body composition: revision of some quantitative assumptions. Ann NY Acad Sci 110: 113–140, 1963. Effros RM and Chinard FP. The in vivo pH of the extravascular space of the lung. J Clin Invest 48: 1983–1996, 1969. (for water content of RBC) Haurowitz, F. Chemistry and Biology of Proteins. New York: Academic Press; 1950. (for rho protein) Allen TH, Krzywicki HJ, Roberts JE. J. Appl. Physiol 1959;14:1005. [PubMed: 13792786] Allen TH, Welch BE, Trujillo TT, Roberts JE. J. Appl. Physiol 1959;14:1009. [PubMed: 13792787]
- Recirculating O2-CO2 BTEX model
- Dash 2016 SHbO2/CO2 dissociation curves
- Dash 2006 BTEX model
- Christmas 2017 O2/CO2 gas solubility calculations
BTEX, PDE, Cardiac grid, Oxygen, CO2, pH, Solubility, tissue exchange, gas exchange, Haldane, Hemoglobin binding, MPC, temperature, metabolism
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[This page was last modified 10Mar20, 4:21 pm.]
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