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# BTEX20_Augmented

Models a tissue cylinder consisting of two regions: plasma and interstitial fluid. Model augmented with additional calculations.

Model number: 0225

 Run JSim model Java Applet: JSim Tutorial

## Description

These partial differential equations model a "tissue cylinder" consisting of two regions. The two regions are capillary plasma, p; and interstitial fluid, isf; there is a diffusional path from plasma to the isf.
This BTEX20 model has been augmented with a visual interface.
This BTEX20 model has been augmented with a MML procedure written in Java to calculate statistics on input and output concentration flow curves.
This BTEX20 model has been augmented with the calculations for the Terminology paper (J.B. Bassingthwaighte, et al., 1986).
This BTEX20 model has been augmented with a comparable two compartment model in order to show that setting the axial diffusion coefficients to large (and unrealistic values) converts a distributed model into a compartmental model.

## Equations

#### Differential Equations

$\large \frac{\partial C_p}{\partial t} = \frac{-F_p \cdot L}{V_p} \cdot \frac{\partial C_p}{\partial x}- \frac{G_p}{V_p} \cdot C_p +\frac{PS_g}{V_{p}}\cdot (C_{isf}-C_p)+D_p \cdot \frac{\partial^2 C_p}{\partial x^2}$
$\large \frac{\partial C_{isf}}{\partial t} = \frac{-G_{isf}}{V'_{isf}} \cdot C_{isf} +\frac{PS_{pc}}{V'_{isf}} \cdot (C_p-C_{isf}) +D_{isf} \cdot \frac{\partial^2 C_{isf}}{\partial x^2}$

#### Left Boundary Conditions

$\large -{\frac {{\it F_p}\cdot L \cdot \left( {\it C_p}-{\it C_{in}} \right) }{{\it V_p}}}+{D_{p} \cdot \it {\frac {\partial}{\partial x}}C_p=0$$\large {\it {\frac {\partial}{\partial x}}C_{isf}=0$ .

#### Right Boundary Conditions

$\large {\it {\frac {\partial }{\partial x}}C_p=0$$\large {\it {\frac {\partial }{\partial x}}C_{isf}=0$$\large {\it C_{out}={\it C_{p}$ .

#### Initial Conditions

$\large C_p=C_p0$ ,   $\large C_{isf}=C_{isf}0$   or
$\large C_p=C_p0(x)$ ,   $\large C_{isf}=C_{isf}0(x)$ .

The equations for this model may also be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

## References


W.C. Sangren and C.W. Sheppard.  A mathematical derivation of the
exchange of a labelled substance between a liquid flowing in a
vessel and an external compartment.  Bull Math BioPhys, 15, 387-394,
1953.

C.A. Goresky, W.H. Ziegler, and G.G. Bach. Capillary exchange modeling:
Barrier-limited and flow-limited distribution. Circ Res 27: 739-764, 1970.

J.B. Bassingthwaighte. A concurrent flow model for extraction
during transcapillary passage.  Circ Res 35:483-503, 1974.

B. Guller, T. Yipintsoi, A.L. Orvis, and J.B. Bassingthwaighte. Myocardial
sodium extraction at varied coronary flows in the dog: Estimation of
capillary permeability by residue and outflow detection. Circ Res 37: 359-378, 1975.

C.P. Rose, C.A. Goresky, and G.G. Bach.  The capillary and
sarcolemmal barriers in the heart--an exploration of labelled water
permeability.  Circ Res 41: 515, 1977.

J.B. Bassingthwaighte, F.P. Chinard, C. Crone, C.A. Goresky,
N.A. Lassen, R.S. Reneman, and K.L. Zierler.  Terminology for
mass transport and exchange.  Am. J. Physiol. 250 (Heart. Circ.
Physiol. 19): H539-H545, 1986.

J.B. Bassingthwaighte, C.Y. Wang, and I.S. Chan.  Blood-tissue
exchange via transport and transformation by endothelial cells.
Circ. Res. 65:997-1020, 1989.

Poulain CA, Finlayson BA, Bassingthwaighte JB.,Efficient numerical methods
for nonlinear-facilitated transport and exchange in a blood-tissue exchange
unit, Ann Biomed Eng. 1997 May-Jun;25(3):547-64.



## Related Models

Blood Tissue Exchange (BTEX) models

## Key Terms

BTEX20,PDE,convection,diffusion,permeation,reaction,distributed,capillary, plasma,isf,interstitial fluid, terminology,statistics,area,transit time,skewness, Tutorial, kurtosis,relative dispersion,RD,Comp2,compartmental,Java,procedure,visual interface