Cardiac output estimation in reference human. An open-loop cardiovascular model composed of a four-chamber varying-elastance heart, a systemic circulation, a pulmonary circulation, a coronary circulation, and baroreceptors.
Model number: 0090
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This is an open-loop cardiovascular and baroreceptor system used to estimate cardiac output from arterial blood pressure and heart rate data. The model is composed of a four-chamber, varying-elastance heart, a systemic circulation, a pulmonary circulation, a coronary circulation, and baroreceptor control of arteriolar resistance, tone, and cardiac contractility. An arterial pressure curve sets the proximal aortic afterload at the downstream end of the circulatory network and acts as input to the baroreceptor equations. At the upstream end a non-pulsatile aortic flow input function automatically adjusts to match simulated mean arterial pressure to the target (measured) mean arterial pressure. The smoothed flow across the pulmonary valve is then taken as the estimated cardiac output. The model also simulates many other physiological features such as total blood volume, end-diastolic left ventricular volume, and coronary capillary flow.
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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- Resistive Element (Model #0069)
- Compliant Element (#0067)
- Single Vessel (#0218)
- Systemic Circulation Olansen et al. 2000 (#0224)
- Pulmonary Circulation Olansen et al. 2000 (#0181)
- Coronary Circulation Zinemanas et al. 1994 (#0128)
- Baroreceptor Lu et al 2001 (#0075)
- Pressure Driven Single Vessel (#0068)
- Ventricle-driven two vessel loop (#0222)
- Stergiopulos 4-element Windkessel (#0219)
- Lumped parameter circulation (#0160)
- Circulation with baroreceptors (#0095)
- Lumped parameter circulation with regulation (#0161)
- Cardiopulmonary mechanics (#0091)
- Cardiopulmonary mechanics with gas exchange (#0092)
- Cardiopulmonary mechanics with gas exchange and blood gas handling (#0093)
- Highly-integrated human (#0153)
- Highly-integrated human with interventions (#0154)
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[This page was last modified 29Jan20, 1:02 pm.]
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