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Cardiac output estimation in reference human. An open-loop cardiovascular model composed of a four-chamber varying-elastance heart, a systemic circulation, a pulmonary circulation, a coronary circulation, and baroreceptors.

Model number: 0090

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 This is an open-loop cardiovascular and baroreceptor system used to estimate cardiac output 
 from arterial blood pressure and heart rate data. The model is composed of a four-chamber, 
 varying-elastance heart, a systemic circulation, a pulmonary circulation, a coronary circulation, 
 and baroreceptor control of arteriolar resistance, tone, and cardiac contractility.

 An arterial pressure curve sets the proximal aortic afterload at the downstream end of the 
 circulatory network and acts as input to the baroreceptor equations. At the upstream end a 
 non-pulsatile aortic flow input function automatically adjusts to match simulated mean arterial 
 pressure to the target (measured) mean arterial pressure. The smoothed flow across the pulmonary 
 valve is then taken as the estimated cardiac output. The model also simulates many other 
 physiological features such as total blood volume, end-diastolic left ventricular volume, and 
 coronary capillary flow. 


The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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Key Terms

cardiac output estimation, cardiovascular system, baroreceptor, systemic circulation, pulmonary circulation, coronary circulation, clinical application, automated parameterization, Publication, Data, PMID17846886, Integrative Physiology

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Posted by: BEJ


Please cite in any publication for which this software is used and send an email with the citation and, if possible, a PDF file of the paper to:
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 29Jan20, 1:02 pm.]

Model development and archiving support at provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.