Two compartments, plasma and interstitial fluid (ISF), with flow and exchange using physiological names and units for parameters and variables. The model is
Model number: 0247
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A flow, Fp, carries an inflow concentration, Cin, into a plasma compartment with volume Vp. The substance is instantaneously well mixed. The material undergoes a passive exchange with an interstitial fluid (ISF) space with volume Visf. No reactions occur in this system. For a constant concentration of inflowing material the analytic steady state solution is Cp=Cin and Cisf=Cin if Psc is positive. Various methods for checking the calculations in a model are illustrated: (1) comparison with an analytic solution, (2) two methods of calculating the amount of material in a compartment with flow, (3) comparison of the running integrals of inflow and outflow concentrations, and (4) calculation of the system transit time of a compartment model with flow by two different methods. The model parameters are optimized to fit a data set.
- Understanding the Comp2FlowExchange Model. (PDF file)