Model for analysis of NMR contrast agents from MRI signal from an organ region of interest (ROI)
Model number: 0265
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Two compartment model for MRI contrast using GdDTPA (gadolinium chelated with diethylenetriamine penta-acetic acid to convert water (W) to water spin (WS). The permeability-surface are product for GdDPTA is PS and for W and WS is PSw. The spin relaxation which converts WS back to W is given by Tr. V1 is the volume of the flowing region and V2 is the volume of the exchange region. The conversion rate is governed by G. Kroll et al. 1996 uses an axially-distributed 1-regional BTEX to analyze data from polylysine-bound GdDTPA, and intravascular indicator. Kroll did not account for WS outside of the vascular space. The WS-Gd relationship was taken to be a saturation curve (Langmuir isotherm). There was no non-exchanging vascular space distinguished from the capillary plasma. Hematocrit was not accounted for.