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Dual comp2 flow-exchange models in series with recirculation and clearance.

Model number: 0285

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A two organ two comparmental model with recirculation for exchange between plasma and ISF in both organs, with an input function, Cin, defined at run time using the function generator. Set Clear to 0 for no clearance, Clear to 1 for complete clearance (no recirculation).

              __________________         __________________
              |V1p      C1p(t) | C1p(t)  |V2p      C2p(t) | C2p(t)
  Cin->--(+)->|                |--->---->|                |--->|
          ^   |     ^ PS1c     |  Flow   |      ^  PS2c   |    |
          |   ------|----------|         -------|=--------|    |
          |   |     v  C1isf(t)|         |      v C2isf(t)|    |
          |   |                |         |                |    v
   Clear \_   |V1isf           |         |V2isf           |    |
          |   -----------------|         ------------------    |
          |                       Flow                         |



     Ordinary Differential Equations

     Initial Conditions

,   ,   ,   ,  

The equations for this model may also be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

Download JSim project file


  Jacquez JA. Compartmental analysis in biology and medicine.
 3rd ed.. Ann Arbor, MI: BioMedware, 1996, 514 pp.

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Two Compartment Models:

N>2 Compartment Models:

Osmotic Exchange:


Key Terms

compartment, compartmental, flow and exchange, mixing chamber, permeability, PS/F, washout, organ, multi-organ, Comp2x2Recirc, Tutorial

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Please cite in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 29Jan20, 1:02 pm.]

Model development and archiving support at provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.