Two compartment model with feedback control of precursor (pregnenolone) to cortisol and its adrenal secretion.
Model number: 0102
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This two compartment model for substances, Q1 (precursor) and Q2 (cortisol) is simplified from the original models of Urquhart (1968) by Jacquez (1972). Precursor Q1 is formed at a rate inhibited by itself at higher concentrations. Its conversion to cortisol is stimulated by ACTH, a saturable process. Increases in ACTH deplete PREG concentration and increase the secretion from the adrenal.
Figure: (Top) Concentration response of cortisol and precursor to ACTH infusion. Q1 is concentration of precurosr in compartment 1 and Q2 is cortisol concentration in compartment 2. (Bottom) ACTH input as a function of time.
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Urquhart J and Li CC. The dynamics of adrenocortical secretion. Am J Physiol 214: 73-85, 1968. Jacquez JA. Compartmental analysis in biology and medicine. Kinetics of distribution of tracer-labeled materials. Amsterdam: Elsevier Publishing Co., 1972, pp.237 (See pp 213-216) Jacquez JA. Compartmental analysis in biology and medicine. 3rd ed.. Ann Arbor, MI: BioMedware, 1996, 514 pp.
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[This page was last modified 29Jan20, 1:02 pm.]
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