Equations and Data for O2 and CO2 solubility in water, normal saline, human & Ox plasma. This model uses individual fit data to express the O2 and CO2 solubility in various biological solutions. Please refer to the Notes tab for further details on the model and files.
Model number: 0397
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Calculates the oxygen and carbon dioxide solubility across a physiolgical range of temperatures through various media (water, 155 mM normal saline, human & Ox plasma. O2 = AO2 *exp(-O2k1 *t) + BO2 *exp(-O2k2 *t). CO2= ACO2*exp(-CO2k1*t) + BCO2*exp(-CO2k2*t).
The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.
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Christmas KM and Bassingthwaighte JB. Equations for O2 and CO2 solubilities in saline and plasma: Combining temperature and density dependences. J Appl Physiol 122: 1313-1320, 2017. The data for gas solubility in water, plasma, and saline was found in the following book. Specific locations for each dataset can be found below: Katz DD, Altman PL, National Research C, and Federation of American Societies for Experimental B. Respiration and circulation, compiled and edited by Philip L. Altman and Dorothy S. Dittmer. Prepared under the auspices of the Committee on Biological Handbooks. Bethesda, Md.: Federation of American Societies for Experimental Biology, 1971, p. 16-18. Specifically pulled from: (Oxygen and carbon dioxide solubility in water) Hodgman, C. D., et al., ed. 1952. Handbook of Chemistry and Physics. Ed. 34. Chemical Rubber, Cleveland. P. 1532. Benson BB, Krause D, and Peterson MA. J. Sol. Chem. 8(9): 655-690, 1979. (Oxygen solubility in 155 normal saline) Sendroy, J., Jr., et al. 1934. J. Biol. Chem. 105:597. (Carbon dioxide solubility for 155 normal saline) Van Slyke, D. D., et al. 1928 J. Biol. Chem. 78:765. (Oxygen solubility in Human plasma) Christoforides, C., and J. Hedley-Whyte. 1969 J. Appl. Physiol. 26(1):56. (Carbon dioxide solubility in Ox plasma) Barels, H., and R. Wrbitzky. 1960. Fluegers Arch. Gesamte Physiol. Menschen Tiere 271:162.
Oxygen, CO2, solubility, plasma, saline, Publication, Data, Cardiac grid, MPC
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[This page was last modified 16Jul18, 5:12 pm.]
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