This page will look better in a graphical browser that supports web standards, but is accessible to any browser or internet device.

Served by Samwise.


Sequence of two catalyzed 1st order Michaelis Menten-type irreversible reactions.

Model number: 0270

Run Model: 
    Help running a JSim model.
Java runtime required. (JSim model may take 10-20 seconds to load.)
MacOS: Adjust "System Preferences" -> "Security & Privacy" to allow Java JSim jnlp app to execute.
More info here.


Two irreversible reactions are governed by Michaelis-Menten kinetics. Consider the following two cases for the first reaction, dA/dt = -VmaxA*A/(KmA+A) : Case 1: A<<KmA, The reaction rate is ~VmaxA/Kma and the flux is VmaxA*(A/KmA)<<VmaxA. Case 2: A>>KmA. The reaction rate is ~VmaxA/A and the flux is VmaxA. The reaction rate is slowest when A<<KmA. The flux is greatest when A>>KmA.

Figure plots concentration (mM) as a function of time of substrate A and its reaction products B and C.


Where Concentrations and Km are in mM, and Vmax has units of mM/sec.

Download JSim model project file


Related Models

Single Compartment Models:

Two Compartment Models:

N>2 Compartment Models:

Osmotic Exchange:


Key Terms

Progress curves, irreversible reactions,PK_PD, pharmacokinetics, first order kinetics, Michaelis-Menten, tutorial, Progress3.MM

Model Feedback

We welcome comments and feedback for this model. Please use the link below to send comments:

Model History

Get Model history in CVS.


Please cite in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 29Jan20, 1:02 pm.]

Model development and archiving support at provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.