This model uses simulates the flow through a single vessel with resistance to flow R and compliance of the vessel, C, derived from a thin walled formulation of vessel wall mechanics.
Model number: 0066
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where is the circumferential stress in the vessel wall, Pin is the intraluminal pressure at the vessel entrance, D is the vessel diameter and wt is the vessel wall thickness. Assuming a linear stress-strain relationship (Hooke's Law) results in where E is the Young's modulus and is the vessel wall strain. Assuming that a zero stress state is reached at a non-zero vessel diameter, Dzs, we can expand the linear stress-strain relationship to be:
Equating these two expressions and solving for D yields:
Now since we know that the definition of the compliance is just and the vessel volume, V, is specified from the vessel diameter and length, L, we can solve for C:
The remaining equations are similar to that of the compliant vessel model. The first equation for flow out of the vessel is related to the resistance by the fluid equivalent of Ohm's Law.
where Pout is the pressure at the outlet of the vessel and R is determined from Poiseuille's Law as:
where is the fluid viscosity. The flow into the vessel and the flow out of the vessel are different because of the change in volume which adds or subtracts flow from that leaving the vessel depending on whether the pressure is increasing or decreasing in the vessel. So we have:
where the flow attributed to the vessel compliance, Fcomp, is given by:
and where V is the vessel volume and is explicitly defined here by the vessel diameter and the length.
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[This page was last modified 14Mar18, 3:17 pm.]
Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.