This Gentex-based model simulates the transport and metabolism processes of exogenous Xa in the isolated, perfused non-working guinea pig heart, based on data from the multiple-indicator dilution technqiue (MID).
Model number: 0422
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This model simulates the transport and metabolism processes of exogenous Xanthine (Xa) and its metabolite utric acid in the isolated, perfused non-working guinea pig heart, based on the data acquired with the multiple-indicator dilution technqiue under the normoxia condition [Schwartz 1999]. The model were developed based on a gentric tissues exchange model,Gentex [Bassingthwaight 2006], which is a whole organ model of the vascular network providing intraorgan flow heterogeneity and accounts for substrate transmembrane transport, binding, and metabolism in erythrocytes, plasma, endothelial cells, interstitial space, and cardiomyocytes.
Figure: Top: Model fit to the dilution curve for the intravascular reference tracer, Albumin (blue), and extravascular reference tracer, L-Glucose (purple). Input function (green), assume a Lag-normal distribution, was derived from curve fitting the dilution curve for the intravascular reference. Bottom: Model fit for the dilution curve of injected tracer Xa (black) and its metabolite UA (red).
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Poulain CA, Finlayson BA, Bassingthwaighte JB.,Efficient numerical methods for nonlinear-facilitated transport and exchange in a blood-tissue exchange unit, Ann Biomed Eng. 1997 May-Jun;25(3):547-64. Bassingthwaighte JB, Raymond GR, Ploger JD, Schwartz LM, and Bukowski TR. GENTEX, a general multiscale model for in vivo tissue exchanges and intraorgan metabolism. Phil Trans Roy Soc : Mathematical, Physical and Engineering Sciences 2006. Schwartz LM, Bukowski TR, Revkin J adn Bassingthwaighte JB. Cardiac endothelial transport and metabolism of adenosine. Am J Physiol. 1999; 277(3): H1241-H1251. Kroll K, Bukowski TR, Schwartz LM, Knoepfler D, and Bassingthwaighte JB. Capillary endothelial transport of uric acid in guinea pig heart. Am. J. Physiol. 262(31): H420-H431. King RB, Bassingthwaighte JB, Hales JRS, Rowell LV. Stability of heterogeneity of myocardial blood flow in normal awake baboons. Circ. Res. 1985, 57:285-295.
purine nucleoside metabolism, convection diffusion reaction model, GENTEX, transporter, xanthane, uric acid, xanthine oxidase, axially distributed blood tissue exchange processes, constrained parameter estimation, simultaneous optimization, data, PDE, BTEX , Cardiac Grid
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Posted by: BEJ
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[This page was last modified 29Jan20, 1:02 pm.]
Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.